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Cited by 26Genomics and Phylogenetic StudiesEvolution and Genetic DynamicsBacterial Genetics and Biotechnology

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Structure and Dynamics of Bacterial Populations: Pangenome Ecology

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Azarian, Taj, Huang, I-Ting, Hanage, William P.·2020·The Pangenome
DOI 10.1007/978-3-030-38281-0_5
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Abstract

Prokaryotes demonstrate tremendous variation in gene content, even within individual bacterial clones or lineages. This diversity is made possible by the ability of bacteria to horizontally transfer DNA through a variety of mechanisms, and the extent of such transfer sets them apart from eukaryotes. What has become evident through interrogation of thousands of bacterial genomes is that gene variation is directly related to the ecology of the organism and is driven by continual processes of niche exploration, diversification, and adaptation. Of course, the acquisition of new genes is not necessarily beneficial, resulting in either the removal of that individual through purifying selection or the occurrence of compensatory mutations in the genomic “backbone” (i.e., core genes) that become epistatically linked to the presence accessory genes. There are now numerous examples of relationship between gene variation and niche adaptation. We explore some of those examples here as well as the population genomic footprint left by the dynamics of gene flow, diversification, and adaptation.

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Metadata

Authors
Azarian, T., Huang, I.-T., & Hanage, W. P.
Affiliations
  • University of Central Florida (US)
  • Harvard University (US)
Corresponding author
Hanage, William P.
ORCID
Venue
The Pangenome
Publisher
Springer International Publishing
Published
2020
Pages
115-128
DOI
10.1007/978-3-030-38281-0_5
OpenAlex
W3020998984
Cited by
26
References
0
Citations by year
2026: 3 · 2025: 2 · 2024: 5 · 2023: 2 · 2022: 3 · 2021: 10 · 2020: 1
FWCI
5.41
Type
book chapter
Language
en
Open access
Licence
Locations
Springer eBooks (publishedVersion, cc-by)
Funders
GlaxoSmithKline
Topics
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Genomics and Phylogenetic Studies
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Evolution and Genetic Dynamics
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Bacterial Genetics and Biotechnology
Keywords
pan-genome, bacterial population dynamics, horizontal gene transfer, gene content variation, niche adaptation, accessory genes, core genes, purifying selection, compensatory mutations, gene flow, bacterial diversification

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