Administration and pharmacokinetics of levothyroxine
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Oral administration of levothyroxine (LT4), which targets the circulating level of thyrotropin (thyroid-stimulating hormone, TSH) to within a predefined reference range, is the mainstay of treatment of hypothyroidism [ 1 , 2 , 3 ]. This chapter summarises the administration, absorption, distribution, metabolism, and elimination of LT4. In addition, it addresses the therapeutic significance of pharmacologic and other factors that can alter exposure to LT4, and of changing regulatory requirements concerning the manufacture of LT4 tablets.
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The plasma elimination half-lives of LT4 and T3 are about 7.5 and 1.4 days, respectively.
“The plasma elimination half-lives of LT4 and T3 are about 7.5 and 1.4 days, respectively 29,30 .”
From A review of the safety of triiodothyronine in combination with levothyroxine for the management of hypothyroidism (2024) · cites this paper as [29]
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References 51 · Cited by 18
Research works printed but not linked: 4
- Peeters RP, Visser TJ. Metabolism of thyroid hormone. Endotext [Internet]. Available at https://www.ncbi.nlm.nih.gov/books/NBK285545. Accessed Jul 2020.
- Bianco AC, da Conceição RR. The deiodinase trio and thyroid hormone signaling. Methods Mol Biol. 1801;2018:67-83.
- Virili C, Antonelli A, Santaguida MG, Benvenga S, Centanni M. Gastrointestinal malabsorp- tion of thyroxine. Endocr Rev. 2019;40:118-36.
- Warade J, Pandey A. Diurnal variation of TSH: factor affecting interpretation of test. J Pharm Biomed Sci. 2014;4:776-80.
- Authors
- Lipp, H.-P.
- Affiliations
- Universitätsklinikum Tübingen (DE)
- Corresponding author
- Lipp, Hans-Peter
- Venue
- 70 Years of Levothyroxine
- Publisher
- Springer International Publishing
- Published
- 2021
- Pages
- 13-22
- OpenAlex
- W3137336434
- Cited by
- 18
- References
- 51
- Citations by year
- 2026: 6 · 2025: 3 · 2024: 4 · 2023: 4 · 2021: 1
- FWCI
- 10.57
- Type
- book chapter
- Language
- en
- Open access
- hybrid
- doi.org
- Licence
- Locations
- Springer eBooks (publishedVersion, cc-by)
- Funders
- Merck KGaA
- Topics
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Thyroid Disorders and Treatments
- Health Sciences › Medicine › Surgery › Thyroid and Parathyroid Surgery
- Life Sciences › Pharmacology, Toxicology and Pharmaceutics › Pharmacology › Medical and Pharmaceutic Studies
- Keywords
- levothyroxine, pharmacokinetics, hypothyroidism, oral administration, drug absorption, drug distribution, drug metabolism, drug elimination, thyroid-stimulating hormone, drug exposure
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