Sarcopenia and Ageing
Abstract
Musculoskeletal ageing is a major health challenge as muscles and bones constitute around 55-60% of body weight. Ageing muscles will result in sarcopenia that is characterized by progressive and generalized loss of skeletal muscle mass and strength with a risk of adverse outcomes. In recent years, a few consensus panels provide new definitions for sarcopenia. It was officially recognized as a disease in 2016 with an ICD-10-CM disease code, M62.84, in the International Classification of Diseases (ICD). With the new definitions, there are many studies emerging to investigate the pathogenesis of sarcopenia, exploring new interventions to treat sarcopenia and evaluating the efficacy of combination treatments for sarcopenia. The scope of this chapter is to summarize and appraise the evidence in terms of (1) clinical signs, symptoms, screening, and diagnosis, (2) pathogenesis of sarcopenia with emphasis on mitochondrial dysfunction, intramuscular fat infiltration and neuromuscular junction deterioration, and (3) current treatments with regard to physical exercises and nutritional supplement.
Integrity signals
Registry
Cites
Statistics
Claims the paper makes
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
Reduced physical activity, resulting from declining muscle function, may create a vicious cycle of further muscle deterioration.
“This suggests that reduced physical activity, resulting from declining muscle function, may create a vicious cycle of further muscle deterioration.17”
From Semaglutide Therapy and Accelerated Sarcopenia in Older Adults with Type 2 Diabetes: A 24-Month Retrospective Cohort Study (2025) · cites this paper as [17]
The citation lists haven’t been fetched yet
References 168 · Cited by 14
- Authors
- Cheng, K. Y.-K., Bao, Z., Long, Y., Liu, C., Huang, T., Cui, C., Chow, S. K.-H., Wong, R. M. Y., & Cheung, W.-H.
- Affiliations
- Chinese University of Hong Kong (HK)
- Corresponding author
- Cheung, Wing-Hoi
- ORCID
- Venue
- Subcellular Biochemistry
- Publisher
- Springer International Publishing
- Published
- 2023
- Volume
- 103
- Pages
- 95-120
- ISSN
- 0306-0225 (ISSN-L)
- 2542-8810
- OpenAlex
- W4367465092
- Cited by
- 14
- References
- 168
- Citations by year
- 2026: 3 · 2025: 8 · 2024: 3
- FWCI
- 19.71
- Type
- book chapter
- Language
- en
- Open access
- closed
- Licence
- Locations
- Sub-cellular biochemistry/Subcellular biochemistry (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Physiology › Nutrition and Health in Aging
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Muscle Physiology and Disorders
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Cell Biology › Muscle metabolism and nutrition
- Keywords
- sarcopenia, aging, skeletal muscle atrophy, muscle strength, sarcopenia definitions, mitochondrial dysfunction, intramuscular fat infiltration, physical activity, dietary supplements, combination therapy
- MeSH terms
- Aging, Humans, Exercise, Muscle, Skeletal, Muscle Strength, Sarcopenia
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
