The DOI matches its Crossref record; 51 of the 51 references it cites were found in a registry or an index.
Mitochondrial Proton Leak Plays a Critical Role in Pathogenesis of Cardiovascular Diseases
Open accessAbstract
Mitochondrial proton leak is the principal mechanism that incompletely couples substrate oxygen to ATP generation. This chapter briefly addresses the recent progress made in understanding the role of proton leak in the pathogenesis of cardiovascular diseases. Majority of the proton conductance is mediated by uncoupling proteins (UCPs) located in the mitochondrial inner membrane. It is evident that the proton leak and reactive oxygen species (ROS) generated from electron transport chain (ETC) in mitochondria are linked to each other. Increased ROS production has been shown to induce proton conductance, and in return, increased proton conductance suppresses ROS production, suggesting the existence of a positive feedback loop that protects the biological systems from detrimental effects of augmented oxidative stress. There is mounting evidence attributing to proton leak and uncoupling proteins a crucial role in the pathogenesis of cardiovascular disease. We can surmise the role of "uncoupling" in cardiovascular disorders as follows; First, the magnitude of the proton leak and the mechanism involved in mediating the proton leak determine whether there is a protective effect against ischemia-reperfusion (IR) injury. Second, uncoupling by UCP2 preserves vascular function in diet-induced obese mice as well as in diabetes. Third, etiology determines whether the proton conductance is altered or not during hypertension. And fourth, proton leak regulates ATP synthesis-uncoupled mitochondrial ROS generation, which determines pathological activation of endothelial cells for recruitment of inflammatory cells. Continue effort in improving our understanding in the role of proton leak in the pathogenesis of cardiovascular and metabolic diseases would lead to identification of novel therapeutic targets for treatment.
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“It has been suggested that increased proton leak is directly related to the prevention of oxidative stress, the inhibition of fatty acid induced mitochondrial damage and the control of oxidative phosphorylation [25], potentially protecting the cell from excessive damage.”
From Heterozygous expression of the Alzheimer’s disease-protective PLCγ2 P522R variant enhances Aβ clearance while preserving synapses (2022) · cites this paper as [25]
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Cites
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Vascular Endothelial Cells and Innate Immunity
Shao, Y., Saredy, J., Yang, W. Y., Sun, Y., Lu, Y., Saaoud, F., Drummer, C., Johnson, C., Xu, K., Jiang, X., et al. (2020) · Arteriosclerosis Thrombosis and Vascular Biology · doi:10.1161/atvbaha.120.314330 · Cited by 302
Self-citationSun, Y., Lu, Y., Saredy, J., Wang, X., Drummer, C., Shao, Y., Saaoud, F., Xu, K., Liu, M., Yang, W. Y., et al. (2020) · Redox Biology · doi:10.1016/j.redox.2020.101696 · Cited by 293
Self-citationSaaoud, F., Liu, L., Xu, K., Cueto, R., Shao, Y., Lu, Y., Sun, Y., Snyder, N. W., Wu, S., Yang, L., et al. (2022) · JCI Insight · doi:10.1172/jci.insight.158183 · Cited by 156
Self-citationJežek, P., Holendová, B., Garlid, K., & Jabůrek, M. (2018) · Antioxidants and Redox Signaling · doi:10.1089/ars.2017.7225 · Cited by 131
Metadata
- Authors
- Cheng, J., Nanayakkara, G., Shao, Y., Cueto, R., Wang, L., Yang, W. Y., Tian, Y., Wang, H., & Yang, X.
- Affiliations
- Harbin Medical University (CN)
- Temple University (US)
- Corresponding author
- Yang, Xiaofeng
- Venue
- Advances in Experimental Medicine and Biology
- Publisher
- Springer International Publishing
- Published
- 2017
- Volume
- 982
- Pages
- 359-370
- ISSN
- 0065-2598 (ISSN-L)
- 2214-8019
- PMC
- PMC5630226
- OpenAlex
- W2617303046
- Cited by
- 168
- References
- 51
- Citations by year
- 2026: 6 · 2025: 22 · 2024: 18 · 2023: 29 · 2022: 25 · 2021: 16 · 2020: 29 · 2019: 8 · 2018: 13 · 2017: 2
- FWCI
- 17.73
- Type
- book chapter
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- Advances in experimental medicine and biology (publishedVersion)
- PubMed (publishedVersion)
- PubMed Central (acceptedVersion)
- Funders
- National Heart, Lung, and Blood Institute (R01HL117654, R01HL138749, R01HL131460, R01HL132399)
- National Institute of Diabetes and Digestive and Kidney Diseases (R01DK113775, R01DK104116)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Mitochondrial Function and Pathology
- Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Cardiac Ischemia and Reperfusion
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › ATP Synthase and ATPases Research
- Keywords
- mitochondrial proton leak, uncoupling proteins, uncoupling, reactive oxygen species, electron transport chain, oxidative stress, ischemia-reperfusion injury, UCP2, vascular function, obesity, diabetes mellitus, hypertension, endothelial activation, inflammation, ATP production, cardiovascular disease pathogenesis
- MeSH terms
- Adenosine Triphosphate, Animals, Cardiovascular Diseases, Electron Transport, Energy Metabolism, Humans, Mitochondria, Heart, Protons, Signal Transduction, Reactive Oxygen Species, Oxidative Stress, Myocytes, Cardiac, Electron Transport Chain Complex Proteins, Membrane Potential, Mitochondrial
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