Alcoholic Liver Disease Accelerates Early Hepatocellular Cancer in a Mouse Model
Abstract
HCC is a rapidly increasing cancer worldwide. Most HCC rises in the setting of chronic and advanced liver disease caused by viral hepatitis, alcohol use, non-alcoholic liver disease or their combination. We found that in the mouse model, alcohol alone does not induce HCC, however, it can promote HCC development after a carcinogen exposure. Multiple mechanisms are involved in carcinogenesis and alcohol affects many of those including epithelial-mesenchymal transition, cancer stem marker expression and inflammation as evidenced in our HCC model.
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Chronic and excessive alcohol intake is known to cause liver injury from mild steatosis (AFLD) to more advanced liver disease such as ASH, fibrosis/cirrhosis, hepatic cancer, liver failure, and death.
“Chronic and excessive alcohol intake is known to cause liver injury from mild steatosis (simple fat accumulation in so-called alcoholic fatty liver disease, AFLD) to more advanced liver disease such as inflammation (alcoholic steatohepatitis, ASH), fibrosis/cirrhosis, hepatic cancer, liver failure, and death203–213.”
From Advanced glycation end products (AGEs) and other adducts in aging-related diseases and alcohol-mediated tissue injury (2021) · cites this paper as [211]
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References 28 · Cited by 4
- Authors
- Szabo, G.
- Venue
- Advances in Experimental Medicine and Biology
- Publisher
- Springer International Publishing
- Published
- 2018
- Volume
- 1032
- Pages
- 71-79
- ISSN
- 0065-2598 (ISSN-L)
- 2214-8019
- OpenAlex
- W2898171965
- Cited by
- 4
- References
- 28
- Citations by year
- 2022: 1 · 2021: 2 · 2019: 1
- FWCI
- 2.89
- Type
- book chapter
- Language
- en
- Open access
- closed
- Licence
- www.springer.com/tdm (tdm)
- Locations
- Advances in experimental medicine and biology (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Pathology and Forensic Medicine › Alcohol Consumption and Health Effects
- Health Sciences › Medicine › Hepatology › Hepatocellular Carcinoma Treatment and Prognosis
- Health Sciences › Medicine › Hepatology › Liver physiology and pathology
- Keywords
- alcoholic liver disease, hepatocellular carcinoma, carcinogen exposure, epithelial-mesenchymal transition, cancer stem cells, inflammation, mouse model
- MeSH terms
- Animals, Disease Models, Animal, Carcinoma, Hepatocellular, Liver Diseases, Alcoholic, Liver Neoplasms, Mice, Epithelial-Mesenchymal Transition
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