The DOI matches its Crossref record; 222 of the 222 references it cites were found in a registry or an index.
cGMP Signalling in the Mammalian Brain: Role in Synaptic Plasticity and Behaviour
Abstract
The second messenger cyclic guanosine 3',5'-monophosphate (cGMP) plays a crucial role in the control of cardiovascular and gastrointestinal homeostastis, but its effects on neuronal functions are less established. This review summarizes recent biochemical and functional data on the role of the cGMP signalling pathway in the mammalian brain, with a focus on the regulation of synaptic plasticity, learning, and other complex behaviours. Expression profiling, along with pharmacological and genetic manipulations, indicates important functions of nitric oxide (NO)-sensitive soluble guanylyl cyclases (sGCs), cGMP-dependent protein kinases (cGKs), and cGMP-regulated phosphodiesterases (PDEs) as generators, effectors, and modulators of cGMP signals in the brain, respectively. In addition, neuronal cGMP signalling can be transmitted through cyclic nucleotide-gated (CNG) or hyperpolarization-activated cyclic nucleotide-gated (HCN) ion channels. The canonical NO/sGC/cGMP/cGK pathway modulates long-term changes of synaptic activity in the hippocampus, amygdala, cerebellum, and other brain regions, and contributes to distinct forms of learning and memory, such as fear conditioning, motor adaptation, and object recognition. Behavioural studies indicate that cGMP signalling is also involved in anxiety, addiction, and the pathogenesis of depression and schizophrenia. At the molecular level, different cGK isoforms appear to mediate effects of cGMP on presynaptic transmitter release and postsynaptic functions. The cGKs have been suggested to modulate cytoskeletal organization, vesicle and AMPA receptor trafficking, and gene expression via phosphorylation of various substrates including VASP, RhoA, RGS2, hSERT, GluR1, G-substrate, and DARPP-32. These and other components of the cGMP signalling cascade may be attractive new targets for the treatment of cognitive impairment, drug abuse, and psychiatric disorders.
Overview
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
In the citing paper
“At the extreme of this spectrum, it is known that for inducible NOS to kill microbes, parasites, or cancer cells, high levels of NO are needed to destroy FeS centers and respiratory proteins in the target organism (28, 31, 32, 46).”
From What Part of NO Don't You Understand? Some Answers to the Cardinal Questions in Nitric Oxide Biology (2010) · cites this paper as [46]
Citations
Cites
Items 201–222 of 222
Embarrassed, but Not Depressed
Carey, M. R., & Lisberger, S. G. (2002) · Neuron · doi:10.1016/s0896-6273(02)00771-7 · Cited by 52
Modulation of synaptic function by cGMP and cGMP-gated cation channels
Barnstable, C. J., Wei, J.-Y., & Han, M. (2004) · Neurochemistry International · doi:10.1016/j.neuint.2004.03.018 · Cited by 51
Nitric Oxide Action on Growth Factor-elicited Signals
Clementi, E., Sciorati, C., Riccio, M., Miloso, M., Meldolesi, J., & Nisticò, G. (1995) · Journal of Biological Chemistry · doi:10.1074/jbc.270.38.22277 · Cited by 49
Wilson, R. I., Gödecke, A., Brown, R. E., et al. (1999) · Neuroscience · doi:10.1016/s0306-4522(98)00479-5 · Cited by 47
Parent, A., Schrader, K. A., Munger, S. D., Reed, R. R., Linden, D. J., & Ronnett, G. V. (1998) · Journal of Neurophysiology · doi:10.1152/jn.1998.79.6.3295 · Cited by 44
A unique role of protein phosphatases in cerebellar long-term depression
Ajima, A., & Ito, M. (1995) · Neuroreport · doi:10.1097/00001756-199501000-00018 · Cited by 41
Kemp‐Harper, B. K., & Feil, R. (2008) · Science Signaling · doi:10.1126/stke.19pe12 · Cited by 38
Self-citationDere, E., Frisch, C. M., Silva, M. A. D. S., Gödecke, A., Schrader, J., & Huston, J. P. (2001) · Neuroscience · doi:10.1016/s0306-4522(01)00382-7 · Cited by 35
Calcium-dependent expression of TNF-α in neural cells is mediated by the calcineurin/NFAT pathway
Canellada, A. M., Cano, E., Sánchez‐Ruiloba, L., et al. (2006) · Molecular and Cellular Neuroscience · doi:10.1016/j.mcn.2005.12.008 · Cited by 34
Aggressive behavior increases after termination of chronic sildenafil treatment in mice
Hotchkiss, A. K., Pyter, L. M., Gatien, M. L., WEN, J., Milman, H. A., & Nelson, R. J. (2004) · Physiology & Behavior · doi:10.1016/j.physbeh.2004.09.005 · Cited by 31
Strijbos, P. J. L. M., Pratt, G. D., Khan, S., et al. (1999) · European Journal of Neuroscience · doi:10.1046/j.1460-9568.1999.00893.x · Cited by 28
Watanabe, Y., Saito, H., & Abe, K. (1995) · Brain Research · doi:10.1016/0006-8993(95)00563-6 · Cited by 28
van Staveren, W. C. G., Ittersum, M. M., Steinbusch, H. W. M., et al. (2005) · Brain Research · doi:10.1016/j.brainres.2004.12.040 · Cited by 23
Mouse Models of NO/Natriuretic Peptide/cGMP Kinase Signaling
Hofmann, F. B., Biel, M., Feil, R., & Kleppisch, T. (2004) · Handbook of experimental pharmacology · doi:10.1007/978-3-642-18934-0_4 · Cited by 17
Self-citationRevermann, M., Maronde, E., Ruth, P., et al. (2002) · Neuroscience Letters · doi:10.1016/s0304-3940(02)01118-7 · Cited by 15
Li, S., Doss, J. C., Hardee, E. J., et al. (2005) · Brain Research · doi:10.1016/j.brainres.2005.01.015 · Cited by 11
Auditory Fear Conditioning and Conditioned Stress Raise NO3– Level in the Amygdala
Sato, T., Suzuki, E., Yokoyama, M., et al. (2006) · Neuropsychobiology · doi:10.1159/000093100 · Cited by 7
Doreulee, N., Brown, R. E., Yanovsky, Y., Gödecke, A., Schrader, J., & Haas, H. L. (2001) · Synapse · doi:10.1002/syn.1074 · Cited by 7
New mouse models for the analysis of cGMP signalling
Feil, R., Feil, S. C., Franken, P., et al. (2007) · BMC Pharmacology · doi:10.1186/1471-2210-7-s1-s19 · Cited by 2
Self-citationPaul, C., Weinmeister, P., Feil, R., et al. (2007) · BMC Pharmacology · doi:10.1186/1471-2210-7-s1-p46 · Cited by 2
Self-citationFunctional roles of isoforms of NO-sensitive guanylyl cyclase
Koesling, D., Mergia, E., Taqatqeh, F., et al. (2007) · BMC Pharmacology · doi:10.1186/1471-2210-7-s1-s44 · Cited by 2
cGMP kinase and food-related behaviours
Sokolowski, M. B. (2007) · BMC Pharmacology · doi:10.1186/1471-2210-7-s1-s46 · Cited by 2
Flagged first, then by citations
Research works printed but not linked: 1
- Hebb DO (1949) The organisation of behavior. A neurophsychological theory. Wiley, New York
Cited by
Sorted by citations
What Part of NO Don't You Understand? Some Answers to the Cardinal Questions in Nitric Oxide Biology
Hill, B. G., Dranka, B. P., Bailey, S. M., Lancaster, J. R., & Darley-Usmar, V. M. (2010) · Journal of Biological Chemistry · doi:10.1074/jbc.r110.101618 · Cited by 310
Drugs of abuse and stress impair LTP at inhibitory synapses in the ventral tegmental area
Niehaus, J. L., Murali, M., & Kauer, J. A. (2010) · European Journal of Neuroscience · doi:10.1111/j.1460-9568.2010.07256.x · Cited by 140
Nitric oxide signalling and antidepressant action revisited
Joca, S. R. L., Sartim, A. G., Roncalho, A. L., Diniz, C. F. A., & Wegener, G. (2019) · Cell and Tissue Research · doi:10.1007/s00441-018-02987-4 · Cited by 63
Metadata
- Authors
- Kleppisch, T., & Feil, R.
- Affiliations
- Technical University of Munich (DE)
- University of Tübingen (DE)
- Corresponding author
- Kleppisch, Thomas
- ORCID
- Feil, Robert
- Venue
- Handbook of Experimental Pharmacology
- Publisher
- Springer Berlin Heidelberg
- Published
- 2009
- Issue
- 191
- Pages
- 549-579
- ISSN
- 0171-2004 (ISSN-L)
- OpenAlex
- W190813598
- Cited by
- 161
- References
- 222
- Citations by year
- 2026: 4 · 2025: 3 · 2024: 4 · 2023: 6 · 2022: 4 · 2021: 9 · 2020: 2 · 2019: 12 · 2018: 9 · 2017: 13 · 2016: 7 · 2015: 3 · 2014: 13 · 2013: 12 · 2012: 20
- FWCI
- 15.46
- Type
- book chapter
- Language
- en
- Open access
- closed
- Licence
- www.springer.com/tdm (tdm)
- Locations
- Handbook of experimental pharmacology (publishedVersion)
- PubMed (publishedVersion)
- mediaTUM – the media and publications repository of the Technical University Munich (Technical University Munich) (submittedVersion)
- Topics
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Phosphodiesterase function and regulation
- Life Sciences › Neuroscience › Cognitive Neuroscience › Memory and Neural Mechanisms
- Keywords
- cGMP signaling, soluble guanylate cyclase, cGMP-dependent protein kinase, phosphodiesterase, nitric oxide, cyclic nucleotide-gated channels, HCN channels, synaptic plasticity, learning and memory, fear conditioning, anxiety, addiction, depression, schizophrenia, AMPA receptor trafficking, vesicle release, cytoskeletal organization, drug abuse, cognitive impairment, mental illness
- MeSH terms
- Animals, Brain, Gene Expression Regulation, Cyclic GMP, Humans, Synaptic Transmission, Neuronal Plasticity, Nitric Oxide, Signal Transduction
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
