Anti-Inflammatory and Anticancer Drugs from Nature
Abstract
Over the centuries, plant extracts have been used to treat various diseases. Until now, natural products have played an important role in anticancer therapy as there are more than 500 compounds from terrestrial and marine plants or microorganisms, which have antioxidant, antiproliferative, or antiangiogenic properties and are therefore able to reduce tumor growth. The recent discovery of new natural products has been accelerated by novel technologies (high throughput screening of natural products in plants, animals, marine organisms, and microorganisms). Vincristine, irinotecan, etoposide, and paclitaxel are examples of compounds derived from plants that are used in cancer treatment. Similarly, actinomycin D, mitomycin C, bleomycin, doxorubicin, and L-asparaginase are drugs derived from microorganisms. In this review, we describe the molecular mechanisms of natural compounds with anti-inflammatory and anticancer activities.
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Products isolated from marine plants have been shown to possess antibacterial, antifungal, analgesic, anti-inflammatory, cytotoxic, hypotensive, and spasmogenic activities.
“Because there is great chemical diversity in marine plants, including marine algae and mangroves, products isolated from these plants have been shown to possess antibacterial, antifungal, analgesic, anti-inflammatory, cytotoxic, hypotensive, and spasmogenic activities [68,69].”
From Marine Natural Products: A Source of Novel Anticancer Drugs (2019) · cites this paper as [68]
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References 90 · Cited by 108
- Authors
- Orlikova, B., Legrand, N., Panning, J., Dicato, M., & Diederich, M.
- Affiliations
- Hôpital Kirchberg (LU)
- Seoul National University (KR)
- Corresponding author
- Diederich, Marc
- ORCID
- Diederich, Marc
- Venue
- Cancer Treatment and Research
- Publisher
- Springer Berlin Heidelberg
- Published
- 2013-10-11
- Volume
- 159
- Pages
- 123-143
- ISSN
- 0927-3042 (ISSN-L)
- OpenAlex
- W1793709550
- Cited by
- 108
- References
- 90
- Citations by year
- 2026: 3 · 2025: 9 · 2024: 5 · 2023: 7 · 2022: 9 · 2021: 7 · 2020: 7 · 2019: 13 · 2018: 9 · 2017: 11 · 2016: 9 · 2015: 11 · 2014: 8
- FWCI
- 12.19
- Type
- book chapter
- Language
- en
- Open access
- closed
- Licence
- Locations
- Cancer treatment and research (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Bioactive natural compounds
- Life Sciences › Agricultural and Biological Sciences › Plant Science › Medicinal Plant Research
- Health Sciences › Medicine › Complementary and alternative medicine › Natural Compounds in Disease Treatment
- Keywords
- natural products, anticancer agents, anti-inflammatory agents, plant extracts, marine natural products, microbial natural products, antioxidant activity, antiproliferative activity, antiangiogenic activity, high-throughput screening, vinca alkaloids, actinomycin D, doxorubicin, molecular mechanisms of drug action
- MeSH terms
- Animals, Anti-Inflammatory Agents, Antineoplastic Agents, Biological Products, Humans, Neoplasms
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