The DOI matches its Crossref record; 1 of the 1 references it cites were found in a registry or an index.
Fluorescence-guided resections of malignant gliomas—An Overview
Abstract
Radical resections of contrast-enhancing tumour in patients with malignant gliomas may be pertinent for survival but are often difficult to achieve due to uncertainties in distinguishing tumour margins intra-operatively. In this respect a number of novel methods are being examined which aim at enhancing resections. Among these methods, resections that exploit the accumulation of fluorescent porphyrins within malignant glioma tissue in response to exogenous administration of a metabolic percursor, 5-aminolevulinic acid, may offer particular advantages. This article summarises the clinical background and current status of 5-ALA drug development for fluorescence-guided resections of malignant gliomas and analyses the available literature with regard to possible mechanisms that govern the highly specific accumulation of fluorescent porphyrins in malignant glioma tissue in response to 5-ALA administration.
Overview
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
Fluorescence-guided gross-total resection has prolonged the survival time of glioblastoma and meningioma patients.
“fluorescence-guided gross-total resection has been developed and it has prolonged the survival time of glioblastoma and meningioma patients [9-12,15,16].”
ALA-photodynamic diagnosis-assisted resection of malignant gliomas results in statistically significant prolongation of postoperative survival.
“Clinical data indicate that ALA-photodynamic diagnosis-assisted resection of malignant gliomas results in statistically significant prolongation of postoperative survival [15,16].”
Citations
Cites
Transport of 5-aminolevulinic acid between blood and brain
Ennis, S. R., Novotny, A., Xiang, J., Shakui, P., Masada, T., Stummer, W., Smith, D. E., & Keep, R. F. (2003) · Brain Research · doi:10.1016/s0006-8993(02)03749-6 · Cited by 146
Self-citation
Flagged first, then by citations
Research works printed but not linked: 11
- Albert FK, Forsting M, Sartor K, Adams HP, Kunze S (1994) Early postoperative magnetic resonance imaging after resection of malignant glioma: objective evaluation of residual tumor and its influence on regrowth and prognosis. Neurosurgery 34: 4560
- McGillion FB, Thompson GG, Moore MR, Goldberg A (1974) The passage of delta-aminolaevulinic acid across the blood-brain barrier of the rat: effect of ethanol. Biochem Pharmacol 23: 472–474 · DOI
- Garcia SC, Moretti MB, Garay MV, Batlle A (1998) Deltaaminolevulinic acid transport through blood-brain barrier. Gen Pharmacol 31: 579–582 · DOI
- Keep RF (2001) The blood-brain barrier. In: Walz W (ed) The neuronal environment: brain homeostasis in health and disease. Humana Press Inc, Totowa, pp 277–307 · DOI
- Kiss R, Dewitte O, Decaestecker C (1997) The combined determination of proliferative activity and cell density in the prognosis of adult patients with supratentorial high-grade astrocytic tumors. Am J Clin Pathol 107: 321–331 · DOI
- Kowalczuk A, Macdonald RL, Amidei C, Dohrmann III F, Erickson RK, Hekmatpanah J, Krauss S, Krishnasamy S, Masters G, Mullan SF, Mundt AJ, Sweeney P, Vokes EE, Weir BKA, Wollman RL (1997) Quantitative imaging study of extent of surgical resection and prognosis of malignant astrocytomas. Neurosurgery 41: 1028–1038 · DOI
- Lacroix M, Abi-Said D, Fourney DR, Gokaslan ZL, Shi W, DeMonte F, Lang FF, McCutcheon IE, Hassenbusch SJ, Holland E, Hess K, Micahle C, Miller D, Sawaya R (2001) A multivariate analysis of 416 patients with glioblastoma multiforme: prognosis, extent of resection, and survival. J Neurosurg 95: 190–198 · DOI
- Stewart DJ (1994) A critique of the role of the blood-brain barrier in the chemotherapy of human brain tumors. J Neurooncol 20(2): 121–139 · DOI
- Stummer W, Novotny A, Stepp H, Goetz C, Bise K, Reulen HJ (2000) Fluorescence-Guided Resection of Glioblastoma Multiforme by Using 5-Aminolevulinic Acid-Induced Porphyrins: a Prospective Study in 52 Consecutive Patients. J Neurosurg 93: 1003–1013 · DOI · Paper page
- Terr L, Weiner LP (1983) An Autoradiographic Study of DeltaAminolevulinic Acid Uptake by Mouse Brain. Exp Neurol 79: 564–568 · DOI
- Wood RJ, Green SB, Shapiro WR (1988) The prognostic importance of tumor size in malignant gliomas: A computed tomographic scan study by the brain tumor cooperative Group. J Clin Oncol 6: 338–343 · DOI
Cited by
Sorted by citations
Novel development of 5-aminolevurinic acid (ALA) in cancer diagnoses and therapy.
Ishizuka, M., Abe, F., Sano, Y., Takahashi, K., Inoue, K., Nakajima, M., Kohda, T., Komatsu, N., Ogura, S.-I., & Tanaka, T. (2011) · International Immunopharmacology · doi:10.1016/j.intimp.2010.11.029 · Cited by 255
Takahashi, K., Ikeda, N., Nonoguchi, N., Kajimoto, Y., Miyatake, S.-I., Hagiya, Y., Ogura, S.-I., Nakagawa, H., Ishikawa, T., & Kuroiwa, T. (2011) · Neuro-Oncology · doi:10.1093/neuonc/nor116 · Cited by 46
RetractedIshikawa, T., Takahashi, K., Ikeda, N., Kajimoto, Y., Hagiya, Y., Ogura, S.-I., Miyatake, S.-I., & Kuroiwa, T. (2011) · Pharmaceutics · doi:10.3390/pharmaceutics3030615 · Cited by 34
Metadata
- Authors
- Stummer, W., Reulen, H. J., Novotny, A., Steppe, H., & Tonn, J. C.
- Affiliations
- Heinrich Heine University Düsseldorf (DE)
- Ludwig-Maximilians-Universität München (DE)
- Venue
- Local Therapies for Glioma Present Status and Future Developments
- Publisher
- Springer Vienna
- Published
- 2003
- Volume
- 88
- Pages
- 9-12
- OpenAlex
- W2265134273
- Cited by
- 128
- References
- 1
- Citations by year
- 2025: 3 · 2024: 3 · 2023: 5 · 2022: 6 · 2021: 4 · 2020: 7 · 2019: 8 · 2018: 7 · 2017: 5 · 2016: 10 · 2015: 12 · 2014: 7 · 2013: 8 · 2012: 4
- FWCI
- 16.50
- Type
- book chapter
- Language
- en
- Open access
- closed
- Locations
- Springer eBooks (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Cancer Research › Photodynamic Therapy Research Studies
- Health Sciences › Medicine › Oncology › Glioma Diagnosis and Treatment
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Porphyrin Metabolism and Disorders
- Keywords
- fluorescence-guided resection, high-grade glioma, 5-aminolevulinic acid, porphyrin accumulation, radical resection, tumour margin delineation, intraoperative imaging, drug development
- MeSH terms
- Aminolevulinic Acid, Biopsy, Blood-Brain Barrier, Brain, Brain Neoplasms, Cell Division, Fluorescence, Germany, Glioma, Humans, Microsurgery, Neovascularization, Pathologic, Postoperative Complications, Prognosis, Protoporphyrins, Sensitivity and Specificity, Survival Rate, Neoplasm, Residual, Ki-67 Antigen
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
