Fundus changes in membranoproliferative glomerulonephritis type II: A fluorescein angiographic study of 23 patients
Abstract
A total of 23 patients aged between 11 and 64 years who had biopsy-proven membranoproliferative glomerulonephritis type II (dense deposit disease) were studied using fluorescein angiography of the retina. With the exception of two adolescents, all patients exhibited small subretinal nodules that were similar to basal laminar drusen. Subjects with a long history of renal disease displayed more numerous and larger nodules as well as atrophic changes. Four subjects presented with subretinal neovascular membranes.
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Homozygous deficiency of CFH in humans and mice results in complement factor alternative pathway dysregulation, membranoproliferative glomerulonephritis type II (MPGN2), and an AMD-like phenotype.
“Homozygous deficiency of CFH in humans and mice results in complement factor alternative pathway dysregulation, the inflammatory renal disease membranoproliferative glomerulonephritis type II (MPGN2), and an AMD-like phenotype (Raines et al., 1989; Leys et al., 1991).”
From Retinal ultrastructure of murine models of dry age-related macular degeneration (AMD) (2010) · cites this paper as Leys et al., 1991
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References 16 · Cited by 57
- Authors
- Leys, A., Vanrenterghem, Y., Van Damme, B., Snyers, B., Pirson, Y., & Leys, M.
- Affiliations
- KU Leuven (BE)
- UCLouvain (BE)
- Ghent University Hospital (BE)
- ORCID
- Leys, Monique
- Venue
- Graefe s Archive for Clinical and Experimental Ophthalmology
- Published
- 1991-09
- Volume
- 229
- Issue
- 5
- Pages
- 406-410
- ISSN
- 0721-832X (ISSN-L)
- 1435-702X
- OpenAlex
- W1964523145
- Cited by
- 57
- References
- 16
- Citations by year
- 2025: 3 · 2022: 1 · 2019: 1 · 2018: 1 · 2017: 2 · 2016: 3 · 2014: 2 · 2013: 3 · 2012: 4
- FWCI
- 1.27
- Type
- journal article
- Language
- en
- Open access
- closed
- Licence
- www.springer.com/tdm (tdm)
- Locations
- Graefe s Archive for Clinical and Experimental Ophthalmology (publishedVersion)
- PubMed (publishedVersion)
- Digital Access to Libraries (Université catholique de Louvain (UCL), l'Université de Namur (UNamur) and the Université Saint-Louis (USL-B)) (submittedVersion)
- Topics
- Health Sciences › Medicine › Nephrology › Renal Diseases and Glomerulopathies
- Health Sciences › Medicine › Ophthalmology › Retinal Diseases and Treatments
- Health Sciences › Medicine › Pulmonary and Respiratory Medicine › Vasculitis and related conditions
- Keywords
- membranoproliferative glomerulonephritis type II, dense deposit disease, fundus changes, fluorescein angiography, subretinal neovascular membrane, retinal atrophy
- MeSH terms
- Adolescent, Adult, Child, Female, Fluorescein Angiography, Fundus Oculi, Humans, Male, Middle Aged, Retinal Diseases, Retrospective Studies, Glomerulonephritis, Membranoproliferative, Retinal Neovascularization, Incidence
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