Comparative study of the pharmacokinetics of zuclopenthixol decanoate and fluphenazine decanoate
Abstract
Seventeen outpatients were treated with depot neuroleptics, zuclopenthixol decanoate in Viscoleo or fluphenazine decanoate in sesame oil, with dosage intervals of 3 weeks. During the 4th, 6th, and 8th dosage interval blood samples were drawn in oxalated tubes. Plasma concentrations of the active neuroleptic drugs, zuclopenthixol and fluphenazine, were determined by high performance liquid chromatography. The concentrations indicated some interindividual as well as intraindividual variations. For zuclopenthixol the maximum concentration was most often seen at day 7 after injection, whereas the kinetics of the fluphenazine concentrations was more variable. There was an indication of more fluctuation in the 4th dosage interval than in the 8th dosage interval, possibly due to the fact that steady state has not yet been achieved at the 4th dosage interval.
Integrity signals
Registry
Cites
Statistics
Claims the paper makes
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
Zuclopenthixol decanoate is administered intramuscularly, and the drug diffuses slowly from the oil depot and hydrolyzes rapidly into the active moiety, zuclopenthixol.
“This formulation is administered intramuscularly, and the drug diffuses slowly from the oil depot and hydrolyzes rapidly into the active moiety, zuclopenthixol [59, 60].”
From Pharmacokinetic Characteristics of Long-Acting Injectable Antipsychotics for Schizophrenia: An Overview (2021) · cites this paper as [60]
Maximum serum concentrations of zuclopenthixol occur in 3-7 days, and the elimination half-life is 19 days.
“Maximum serum concentrations occur in 3–7 days, and the elimination half-life is 19 days [59, 60].”
From Pharmacokinetic Characteristics of Long-Acting Injectable Antipsychotics for Schizophrenia: An Overview (2021) · cites this paper as [60]
The citation lists haven’t been fetched yet
References 14 · Cited by 24
- Authors
- Viala, A., Ba, B., Durand, A., Gouezo, F., Hou, N., & J�rgensen, A.
- Affiliations
- University of Copenhagen (DK)
- ORCID
- Ba, B.
- Venue
- Psychopharmacology
- Published
- 1988-03
- Volume
- 94
- Issue
- 3
- Pages
- 293-7
- ISSN
- 0033-3158 (ISSN-L)
- 1432-2072
- OpenAlex
- W1994586716
- Cited by
- 24
- References
- 14
- Citations by year
- 2025: 4 · 2024: 1 · 2023: 1 · 2021: 3 · 2020: 1 · 2017: 2 · 2015: 1 · 2013: 1
- FWCI
- 0.37
- Type
- journal article
- Language
- en
- Open access
- closed
- Licence
- www.springer.com/tdm (tdm)
- Locations
- Psychopharmacology (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Psychiatry and Mental health › Schizophrenia research and treatment
- Life Sciences › Pharmacology, Toxicology and Pharmaceutics › Pharmacology › Pharmacogenetics and Drug Metabolism
- Social Sciences › Psychology › Clinical Psychology › Historical Psychiatry and Medical Practices
- Keywords
- fluphenazine decanoate, depot neuroleptics, pharmacokinetics, plasma drug concentration, intramuscular injection, steady state, interindividual variability, within-person variability, antipsychotic drugs
- MeSH terms
- Adult, Clopenthixol, Female, Fluphenazine, Humans, Male, Middle Aged, Schizophrenia, Thioxanthenes, Tranquilizing Agents, Antipsychotic Agents
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
