Radioligand binding evidence implicates the brain 5-HT2 receptor as a site of action for LSD and phenylisopropylamine hallucinogens

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1. Behavioral, physiological and neuroendocrine responses in healthy volunteers to m -chlorophenylpiperazine ( m -CPP) with and without ondansetron pretreatment
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2. Complex stimulus properties of LSD: a drug discrimination study with α2-adrenoceptor agonists and antagonists
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3. Neurochemical and Behavioral Effects of a New Hallucinogenic Compound 25B-NBOMe in Rats
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4. Receptor Binding Profiles for Tryptamine Psychedelics and Effects of 4-Propionoxy-N,N-dimethyltryptamine in Mice
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5. A comparison of N,N-dimethyltryptamine, harmaline, and selected congeners in rats trained with LSD as a discriminative stimulus
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6. Neurotoxic Effects of 5-MeO-DIPT: A Psychoactive Tryptamine Derivative in Rats
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7. SEROTONIN 5HT2A RECEPTOR ACTIVATION INHIBITS INDUCIBLE NITRIC OXIDE SYNTHASE ACTIVITY IN C6 GLIOMA CELLS
   Keith J. Miller, Chara L Mariano, Wendy R Cruz · 1997 · Life Sciences
8. Cross-tolerance studies of serotonin receptors involved in behavioral effects of LSD in rats
   Kirsten Krebs-Thomson, Mark A. Geyer · 1994 · Psychopharmacology
9. Agonist-induced functional desensitization of recombinant human 5-HT2 receptors expressed in CHO-K1 cells22Abbreviations: 5-HT, 5-hydroxytryptamine; CHO, Chinese hamster ovary; PI, phosphoinositide; FLIPR, fluorimetric imaging plate reader; mCPP, m-chlorophenylpiperazine; DOI, 2,5-dimethoxy-4-iodoamphetamine hydrobromide, GPCR, G-protein-coupled receptor; and PCR, polymerase chain reaction.
   Richard H.P. Porter, Craig S. Malcolm, Nicola H. Allen, Helen Lamb, Dean F. Revell, Malcolm J. Sheardown · 2001 · Biochemical Pharmacology
10. Evidence for involvement of 5-HT1C and 5-HT2 receptors in the food intake suppressant effects of 1-(2,5-dimethoxy-4-iodophenyl)-2-aminopropane (DOI)
    Charanjit S. Aulakh, James Hill, Hakan T. Yoney, Dennis L. Murphy · 1992 · Psychopharmacology
11. Serotonin and the Action of LSD in the Brain
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12. Interaction between LSD and dopamine D2/3 binding sites in pig brain
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13. Addiction research in a simple animal model: the nematode Caenorhabditis elegans
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14. Stereoselective LSD-like Activity in a Series of d-Lysergic Acid Amides of (R)- and (S)-2-Aminoalkanes
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15. Long-term antidepressant treatments alter 5-HT2A and 5-HT2C receptor-mediated hyperthermia in Fawn-Hooded rats
    Charanjit S. Aulakh, Pascale Mazzola‐Pomietto, Dennis L. Murphy · 1995 · European Journal of Pharmacology
16. Cross-familiarisation conditioned taste aversion procedure as a method to reveal stimulus resemblance between drugs: studies on the 5-HT1A agonist 8-OHDPAT
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17. MDMA Effects in Brain: Pharmacologic Profile and Evidence of Neurotoxicity from Neurochemical and Autoradiographic Studies
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18. Serotonin and Serotonin Receptors in Hallucinogen Action
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19. Synthesis and Pharmacological Evaluation of Ring-Methylated Derivatives of 3,4-(Methylenedioxy)amphetamine (MDA)
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20. Molecular structural basis of ligand selectivity for 5-HT2 versus 5-HT1C cortical receptors
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21. A novel behavioral model that discriminates between 5-HT2A and 5-HT2C receptor activation
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22. Serotonin 5‐HT2A Receptor Activation Inhibits Cytokine‐stimulated Inducible Nitric Oxide Synthase in C6 Glioma Cellsa
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23. Effects of repeated treatment with 1-(2,5-dimethoxy-4-iodophenyl)-2-aminopropane (DOI) on the autoregulatory control of dorsal raphe 5-HT neuronal firing and cortical 5-HT release
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24. Differential signaling signatures evoked by DOI versus lisuride stimulation of the 5-HT2A receptor
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25. Classical Hallucinogens
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27. Chronic Phenethylamine Hallucinogen Treatment Alters Behavioral Sensitivity to a Metabotropic Glutamate 2/3 Receptor Agonist
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28. One-pot Claisen rearrangement/O-methylation/alkene isomerization in the synthesis of ortho-methoxylated phenylisopropylamines
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29. Investigation of the 2,5-Dimethoxy Motif in Phenethylamine Serotonin 2A Receptor Agonists
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31. Animal Models for Assessing Hallucinogenic Agents
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32. α-Adrenergic and 5-HT2-serotonergic effects of some β-phenylethylamines on isolated rat thoracic aorta
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33. Optimising PET approaches to measuring 5‐ HT release in human brain
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34. The 2014 Philip S. Portoghese Medicinal Chemistry Lectureship: The “Phenylalkylaminome” with a Focus on Selected Drugs of Abuse
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35. Monoamine receptor interaction profiles of 4-aryl-substituted 2,5-dimethoxyphenethylamines (2C-BI derivatives)
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36. Acute Effects of LSD on Rhesus Monkey Operant Test Battery Performance
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37. Withdrawal from chronic cocaine enhances behavioral sensitivity to the 5-HT2/1C agonist DOI
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38. Pre-treatment with 3,4-methylenedioxymethamphetamine (MDMA) causes long-lasting changes in 5-HT2A receptor-mediated glucose utilization in the rat brain
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39. Pharmacology and Biochemistry of the 5-HT2 Receptor
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40. Effects of LSD on music-evoked brain activity
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41. Effects of ritanserin and 1-(2,5-dimethoxy-4-iodophenyl)-2-aminopropane (DOI) in the murine elevated plus-maze test of anxiety: an ethopharmacological study
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42. Effects of hallucinogenic drugs on the human heart
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43. Electrophysiology of Serotonin Receptors
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44. Drug discrimination and receptor binding studies of N-isopropyl lysergamide derivatives
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45. Identification of 5-hydroxytryptamine1A receptor agents using a composite pharmacophore analysis and chemical database screening
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46. Agonist binding fraction of dopamine D2/3 receptors in rat brain: A quantitative autoradiographic study
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47. Activation of 5-HT 2A receptors by TCB-2 induces recurrent oscillatory burst discharge in layer 5 pyramidal neurons of the mPFC in vitro
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48. Indolealkylamines in Mucuna species
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49. The interactions of typical and atypical antipsychotics with the (−)2,5,-dimethoxy-4-methamphetamine (DOM) discriminative stimulus
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50. Cardiovascular effects of bufotenin on human 5-HT4 serotonin receptors in cardiac preparations of transgenic mice and in human atrial preparations
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51. Present and future of metabolic and metabolomics studies focused on classical psychedelics in humans
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54. Using alternative SMILES representations to identify novel functional analogues in chemical similarity vector searches
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57. Synthesis of Novel (Phenylalkyl)amines for the Investigation of StructureActivity Relationships, Part 3
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62. Recent Developments in the Neurobiology of Dissociation
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63. 25CN-NBOMe Metabolites in Rat Urine, Human Liver Microsomes and C. elegans—Structure Determination and Synthesis of the Most Abundant Metabolites
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67. Synthesis of 1-[2′,5′-dimethoxy-4′-(β-fluoroethyl)phenyl]-2-aminopropane:studies related to 18F-labeled serotonin receptor ligands
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71. Regulation of 5-HT2A/C receptors and DOI-induced behaviors by protein kinase Cγ
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72. Discriminative stimulus effects of N,N-diisopropyltryptamine
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73. Position 5.46 of the Serotonin 5-HT2A Receptor Contributes to a Species-Dependent Variation for the 5-HT2C Agonist (R)-9-Ethyl-1,3,4,10b-tetrahydro-7-trifluoromethylpyrazino[2,1-a]isoindol-6(2H)-one: Impact on Selectivity and Toxicological Evaluation
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