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Cited by 73Visual perception and processing mechanismsVestibular and auditory disordersNeuroscience and Neuropharmacology Research

The DOI matches its Crossref record; 43 of the 43 references it cites were found in a registry or an index.

The organization of descending tectofugal pathways underlying orienting in the frog, Rana pipiens: II. Evidence for the involvement of a tecto-tegmento-spinal pathway

Masino, T., Grobstein, P.·1989·Experimental Brain Research
DOI 10.1007/bf00247932
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Abstract

In the frog, identical orienting deficits, involving a failure to turn toward stimuli in the ipsilateral hemifield, can be produced by small white matter lesions either in the caudal mesencephalon (Kostyk and Grobstein, 1987a) or in the caudal medulla (Masino and Grobstein, 1989). These findings suggest that descending turn signals may run uninterrupted from the midbrain to the spinal cord, and that something other than tectospinal axons may carry such signals. We here report studies to determine whether there is a tecto-recipient structure whose axons pass through the known critical lesion sites in the caudal mesencephalon and medulla, and whether damage to such a structure, sparing tectospinal pathways, produces an orienting deficit. Horseradish peroxidase (HRP) was applied to behaviorally effective lesions in the caudal medulla and the resulting labelling patterns compared with those resulting from application of HRP to nearby but behaviorally ineffective lesions at the same rostrocaudal level. A column of large cells in the ventrolateral midbrain tegmentum (including nMLF as well as parts of AV and PV) was robustly labelled in all effective lesion cases, and less frequently labelled in ineffective cases. A quantitative analysis showed labelling in this region to be more highly correlated with the existence of a behavioral deficit than that in any other brain region. Reconstructions of single retrogradely labelled cells in the rostral part of the column (nMLF) showed that they have dendrites in a position to receive tectal input and axons which pass through the critical lesion sites in both the caudal mesencephalon and the caudal medulla. Tegmental lesions, sparing the tectospinal tracts, produced ipsilateral turning deficits in cases where the large cell column was completely removed but did not when the column was spared. The findings support the hypothesis that tectofugal signals involved in orienting turns descend uninterrupted to the spinal cord on something other than tectospinal axons, and suggest that the critical projections derive from the large cell column of the ventral tegmentum.

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Crossref · 10.1007/bf00247932

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Citations

Cites

Research works printed but not linked: 5

  1. Cajal S Ramon y (1911) Histologie du système nerveux de l'homme et des vertébrés. Maloine, Paris
  2. Grantyn A, Berthoz A (1988) The role of the tectoreticular system in the control of head movements. In: Peterson BW, Rich-mond FJ (eds) Control of head movement. Oxford University Press, New York
  3. Ingle D, Sprague JM (1975) Sensorimotor functions of the midbrain tectum. Neurosci Res Prog Bull 13: 173–288
  4. Larson-Prior LJ (1986) The red nucleus of ranid amphibians: cellular organization in the tegmental fields of Potter. PhD. thesis. Kent State University
  5. Masino T, Grobstein P (1986) Sensorimotor circuitry underlying directed movement in the frog: organization of tectofugal pathways and likely involvement of the nMLF. Soc Neurosci Abstr 12: 684

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Metadata

Authors
Masino, T., & Grobstein, P.
Affiliations
University of Chicago (US)
Venue
Experimental Brain Research
Publisher
Springer Science and Business Media LLC
Published
1989-04
Volume
75
Issue
2
Pages
245-264
ISSN
  • 0014-4819 (ISSN-L)
  • 1432-1106
DOI
10.1007/bf00247932
OpenAlex
W2615518909
Cited by
73
References
43
Citations by year
2025: 1 · 2024: 1 · 2021: 1 · 2016: 2
FWCI
9.48
Type
journal article
Language
en
Open access
closed
Licence
www.springer.com/tdm (tdm)
Locations
  • Experimental Brain Research (publishedVersion)
  • PubMed (publishedVersion)
Funders
  • National Institutes of Health (1r15ns024968-01)
  • National Institute of General Medical Sciences (1 T32 GM 07839, T32GM007839)
  • National Institute of Neurological Disorders and Stroke (1 R15 NS 24968)
Topics
  • Life Sciences › Neuroscience › Cognitive Neuroscience › Visual perception and processing mechanisms
  • Life Sciences › Neuroscience › Neurology › Vestibular and auditory disorders
  • Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
Keywords
orienting, tectofugal pathway, caudal medulla, white matter lesions, retrograde tracing, Rana pipiens, frogs
MeSH terms
Animals, Efferent Pathways, Horseradish Peroxidase, Mesencephalon, Orientation, Rana pipiens, Spinal Cord, Superior Colliculi

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