Delayed maturation of the vagus nerve in sudden infant death syndrome
Abstract
Abnormalities of the respiratory control system have been implicated in the cause of death in sudden infant death syndrome (SIDS). The vagus nerve is a major component of the neural regulation of respiration. Ultrastructural quantitative morphometry of myelinated and unmyelinated fibers was performed on cervical vagus nerves taken from 30 SIDS victims and 29 age-matched controls between 1 and 9 months of age. In SIDS infants, more small and fewer large myelinated vagal fibers were found than in controls, suggesting that the vagus nerve in SIDS is relatively immature. Delayed vagal nerve maturation, together with delays in central nervous system myelination and dendritic development, indicates a neural developmental delay in SIDS, the cause of which is undetermined.
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A deficiency in myelinated cardioinhibitory fibers originating in the ventral vagal nucleus may lower the threshold to neurogenic bradycardia through unmyelinated cardioinhibitory fibers originating in the dorsal motor nucleus of the vagus.
“When there is a deficiency in the number of myelinated cardioinhibitory fibers originating in the ventral vagal nucleus there may be a lower threshold (see dissolution below) to neurogenic bradycardia (potentially augmented by ionotropic influences) through the unmyelinated cardioinhibitory fibers originating in the dorsal motor nucleus of the vagus (e.g., Ref. [47]).”
From The vagal paradox: A polyvagal solution (2023) · cites this paper as [47]
A deficiency in myelinated vagal cardioinhibitory fibers has been reported in infants who died from sudden infant death syndrome.
“This deficiency has been reported in infants who have died from sudden infant death syndrome, a disorder assumed to be associated with neurogenic bradycardia [47].”
From The vagal paradox: A polyvagal solution (2023) · cites this paper as [47]
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References 37 · Cited by 42
- Authors
- Becker, L. E., Zhang, W., & Pereyra, P. M.
- Affiliations
- University of Toronto (CA)
- Venue
- Acta Neuropathologica
- Published
- 1993-11
- Volume
- 86
- Issue
- 6
- Pages
- 617-622
- ISSN
- 0001-6322 (ISSN-L)
- 1432-0533
- OpenAlex
- W2083263031
- Cited by
- 42
- References
- 37
- Citations by year
- 2025: 2 · 2023: 4 · 2022: 4 · 2021: 1 · 2018: 1 · 2016: 1 · 2015: 3 · 2014: 4 · 2013: 1 · 2012: 1
- FWCI
- 1.34
- Type
- journal article
- Language
- en
- Open access
- closed
- Licence
- www.springer.com/tdm (tdm)
- Locations
- Acta Neuropathologica (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Life Sciences › Neuroscience › Endocrine and Autonomic Systems › Neuroscience of respiration and sleep
- Life Sciences › Neuroscience › Neurology › Vagus Nerve Stimulation Research
- Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Heart Rate Variability and Autonomic Control
- Keywords
- sudden infant death syndrome, vagus nerve, myelinated axons, unmyelinated nerve fibers, neuronal maturation, respiratory control, cervical vagus nerve, myelination, dendritic development
- MeSH terms
- Aging, Humans, Infant, Nerve Fibers, Nerve Fibers, Myelinated, Sudden Infant Death, Vagus Nerve
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