Altered islet amyloid polypeptide (amylin) gene expression in rat models of diabetes
Open accessAbstract
The response of the islet amyloid polypeptide gene to chronic dexamethasone treatment in adult rats was investigated. After 12 daily injections, rats were severely underweight and fasting blood glucose levels were elevated. When pancreatic mRNA was analysed, a 16-fold elevation in islet amyloid polypeptide mRNA was observed with only a four-fold increase in insulin mRNA levels. Pancreatic islet amyloid polypeptide and insulin mRNA levels were also determined 12 days after streptozotocin treatment. In these rats, which were not severely diabetic, the reduction in islet amyloid polypeptide mRNA levels was sixfold less than the reduction in insulin mRNA levels. In both these models of diabetes the ratio of islet amyloid polypeptide to insulin mRNA levels was raised. This would not be expected if the physiological role of islet amyloid polypeptide is as a simple hyperglycaemic agent opposing insulin action or release.
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Islet amyloid deposits are very likely directly involved in the pathogenesis of T2D.
“What has become clear is that islet amyloid deposits are very likely to be directly involved in the pathogenesis of T2D, although it has not been well established how mechanistically.124,126,127”
From A review of current trends with type 2 diabetes epidemiology, aetiology, pathogenesis, treatments and future perspectives (2021) · cites this paper as [126]
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References 6 · Cited by 71
- Authors
- Bretherton-Watt, D., Ghatei, M. A., Bloom, S. R., Jamal, H., Ferrier, G. J. M., Girgis, S. I., & Legon, S.
- Affiliations
- Hammersmith Hospital (GB)
- Venue
- Diabetologia
- Published
- 1989-12
- Volume
- 32
- Issue
- 12
- Pages
- 881-883
- ISSN
- 0012-186X (ISSN-L)
- 1432-0428
- OpenAlex
- W2047135359
- Cited by
- 71
- References
- 6
- Citations by year
- 2021: 1 · 2018: 2 · 2017: 1 · 2015: 1 · 2014: 1 · 2012: 1
- FWCI
- 9.25
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Licence
- www.springer.com/tdm (tdm)
- Locations
- Diabetologia (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Surgery › Pancreatic function and diabetes
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Diabetes Treatment and Management
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Diabetes and associated disorders
- Keywords
- amylin, gene expression, dexamethasone, streptozotocin-induced diabetes, insulin mRNA, pancreatic islets, hyperglycemia, glucocorticoids, diabetes model
- MeSH terms
- Amyloid, Animals, Blood Glucose, Dexamethasone, Diabetes Mellitus, Experimental, Genes, Male, Rats, Inbred Strains, Reference Values, RNA, Messenger, Transcription, Genetic, Gene Expression, Rats, Islet Amyloid Polypeptide
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