Extracellular matrix receptor and platelet antigens on osteoclasts and foreign body giant cells
Abstract
Osteoclasts (OCs) and other cells of the mononuclear phagocyte system possess receptors for adhesive proteins present in the extracellular matrix. The antigenic phenotype of OCs and foreign body giant cells (FBGCs) was investigated for the presence of several integrin molecules and other largely platelet-associated antigens involved in cell adhesion reactions. Both OCs and FBGCs expressed the alpha-chains of the vitronectin receptor (CD51) and of the VLA-2 (CDw49b) and VLA-4 (CDw49d) molecules as well as their respective beta-chains, gpIIIa (CD61) and CD29. OCs and FBGCs also expressed CD9 and CD55 (DAF-Decay Accelerating Factor) and strongly reacted with antibodies directed against fibrinogen, fibronectin and vitronectin; the latter are ligands for several of the above matrix protein receptors. The data suggest that cell-cell and cell-matrix interactions involving adhesive proteins may be important in OC and FBGC function.
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α and β integrin subunits for the vitronectin receptor (CD51/CD61), very late antigen receptor (VLA-2, CDw49b/CD29) and VLA-4 receptor (CDw49d/CD29) were detected on foreign body giant cells.
“Additionally, α and β integrin subunits for the vitronectin receptor (CD51/CD61), very late antigen receptor (VLA-2, CDw49b/CD29) and VLA-4 receptor (CDw49d/CD29) were detected on foreign body giant cells.[78]”
From Foreign body reaction to biomaterials (2008) · cites this paper as [78]
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References 34 · Cited by 25
- Authors
- Quinn, J. M. W., Athanasou, N. A., & McGee, J. O.
- Affiliations
- John Radcliffe Hospital (GB)
- Venue
- Histochemistry
- Published
- 1991-06
- Volume
- 96
- Issue
- 2
- Pages
- 169-176
- ISSN
- 0948-6143 (ISSN-L)
- 0301-5564
- 1432-119X
- OpenAlex
- W2045491514
- Cited by
- 25
- References
- 34
- Citations by year
- 2025: 2 · 2022: 1 · 2018: 1 · 2017: 1 · 2015: 1
- FWCI
- 0.60
- Type
- journal article
- Language
- en
- Open access
- closed
- Licence
- www.springer.com/tdm (tdm)
- Locations
- Histochemistry and Cell Biology (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Immunology and Allergy › Cell Adhesion Molecules Research
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Bone Metabolism and Diseases
- Health Sciences › Medicine › Rheumatology › Bone and Dental Protein Studies
- Keywords
- osteoclasts, foreign body giant cells, extracellular matrix receptors, integrins, integrin αvβ3, ITGAV, alpha2beta1 integrin, VLA-4, beta1 integrin, glycoprotein IIIa, CD9, CD55, platelet antigens, fibrinogen, fibronectin, vitronectin, cell adhesion, cell-matrix interactions, antigenic phenotype
- MeSH terms
- Fibrinogen, Fibronectins, Glycoproteins, Hip Joint, Humans, Immunoenzyme Techniques, Osteoclasts, Receptors, Cell Surface, Giant Cells, Foreign-Body, Integrins, Antigens, Human Platelet, Vitronectin
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