The DOI matches its Crossref record; 24 of the 24 references it cites were found in a registry or an index.
Autoradiographic studies on the distribution of 3H-2,3,4-trimethoxy-?-phenylethylamine in the mouse
Abstract
The regional distribution of radioactivity was studied in the brain and in other organs of the mouse by light microscopic autoradiography after injection of 3H-2,3,4-trimethoxy-beta-phenylethylamine (2,3,4,-TMPEA), a nonhallucinogenic isomer of mescaline. The distribution patterns were compared with biochemical and autoradiographic results obtained after 3H-mescaline. Although 2,3,4-TMPEA is rapidly deaminated compared to mescaline its distribution pattern in the brain is similar to that of mescaline at 1 h after injection. However, contrary to mescaline the radioactive labeling becomes more and more homogenously distributed in the brain with tiem. The distribution patterns in kidney, pancreas, adrenal, and spinal ganglia were also different from those observed after application of 3H-mescaline.
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“Similar studies in mice with the non-hallucinogenic isomer of mescaline, [3H]-2,3,4-trimethoxy-β-phenylethylamine (4 mg) showed a more homogeneous pattern of binding [77]”
From Molecular and Functional Imaging Studies of Psychedelic Drug Action in Animals and Humans. (2021) · cites this paper as [77]
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Cites
A relationship between the hallucinogenic activity of drugs and their electronic configuration.
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Steric and Electronic Relationships among Some Hallucinogenic Compounds
Kang, S., & Green, J. P. (1970) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.67.1.62 · Cited by 64
Distribution and fate of C14-amitriptyline in mice and rats
Cassano, G. B., Sj�strand, S. E., & Hansson, E. (1965) · Psychopharmacology · doi:10.1007/bf00405356 · Cited by 58
Structure-activity relationship studies on mescaline
Smythies, J., Bradley, R. J., Johnston, V. S., Benington, F., Morin, R. D., & Clark, L. C. (1967) · Psychopharmacology · doi:10.1007/bf00403978 · Cited by 44
Über den Abbau des Mescalins und mescalinähnlicher Stoffe im Organismus.
Slotta, K. H., & Müller., J. (1936) · Hoppe-Seyler´s Zeitschrift für physiologische Chemie · doi:10.1515/bchm2.1936.238.1-3.14 · Cited by 42
Fischer, H. A., & Werner, G. (1971) · De Gruyter eBooks · doi:10.1515/9783111726830 · Cited by 38
The distribution of 35S-chlorpromazine in mice studied by whole body autoradiography.
Sjöstrand, S. E., Gb, C., & Hansson, E. (1965) · PubMed · Cited by 34
LSD: Autoradiographic Study on the Placental Transfer and Tissue Distribution in Mice
Idänpään-Heikkilä, J. E., & Schoolar, J. C. (1969) · Science · doi:10.1126/science.164.3885.1295 · Cited by 32
Distribution of Carbon‐14 Labeled Isoniazid in Brain
Barlow, C. F., Schoolar, J. C., & Roth, L. J. (1957) · Neurology · doi:10.1212/wnl.7.12.820 · Cited by 26
Autoradiographic distribution studies in mice with C14-imipramine.
Gb, C., & Hansson, E. (1966) · PubMed · Cited by 23
Research works printed but not linked: 3
- Eckert, H., Hopf, A.: Autoradiographische Untersuchungen �ber die Verteilung des Thioxanthen-Derivates 14C-BP 400 im Rattenhirn. Arzneimittel-Forsch. 20, 1712?1716 (1970b)
- Seiler, N., Demisch, L.: Regional metabolism of 3,4,5-trimethoxy-?-phenylethylamine (mescaline) and 2,3,4-trimethoxy-?-phenylethylamine in mouse brain in vivo. Abstr. 3rd Intern. Meeting of the Intern. Soc. Neurochem., p. 331. Budapest: Akad�mia Kiado 1971b
- Seiler, N., Demisch, L.: Metabolism of mescaline and of 2,3,4-trimethoxy-?-phenylethylamine in brain in vivo. In: Psychiatric Research Meeting 1971, A. A. Boulton, and A. H. Neufeldt, eds., pp. 78?85. Saskatoon 1971c
Cited by
Sorted by citations
Structure-Activity Relationships of Phenethylamine Hallucinogens
Nichols, D. E. (1981) · Journal of Pharmaceutical Sciences · doi:10.1002/jps.2600700802 · Cited by 47
Molecular and Functional Imaging Studies of Psychedelic Drug Action in Animals and Humans.
Cumming, P., Scheidegger, M., Dornbierer, D., Palner, M., Quednow, B. B., & Martin-Soelch, C. (2021) · Molecules · doi:10.3390/molecules26092451 · Cited by 43
“Similar studies in mice with the non-hallucinogenic isomer of mescaline, [3H]2,3,4-trimethoxy-β-phenylethylamine (4 mg) showed a more homogeneous pattern of binding [77], suggesting that mescaline (6) evokes hallucinations through specific receptors or binding sites.”
ResultKorr, H. (1976) · Psychopharmacologia · doi:10.1007/bf00421558 · Cited by 5
Self-citation
Metadata
- Authors
- Korr, H., & Seiler, N.
- Affiliations
- University of Würzburg (DE)
- Max Planck Institute for Brain Research (DE)
- Venue
- Psychopharmacologia
- Published
- 1976
- Volume
- 46
- Issue
- 1
- Pages
- 53-58
- ISSN
- 0033-3158 (ISSN-L)
- 1432-2072
- OpenAlex
- W1995718663
- Cited by
- 3
- References
- 24
- Citations by year
- 2021: 1
- FWCI
- 0.87
- Type
- journal article
- Language
- en
- Open access
- closed
- Licence
- www.springer.com/tdm (tdm)
- Locations
- Psychopharmacology (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Social Sciences › Psychology › Clinical Psychology › Psychedelics and Drug Studies
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neurotransmitter Receptor Influence on Behavior
- Life Sciences › Pharmacology, Toxicology and Pharmaceutics › Pharmacology › Alkaloids: synthesis and pharmacology
- Keywords
- brain distribution, tissue distribution, deamination, autoradiography
- MeSH terms
- Animals, Autoradiography, Brain, Eye, Liver, Male, Mescaline, Spinal Cord, Mice
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- CoChat. (2026). Citation check: Autoradiographic studies on the distribution of 3H-2,3,4-trimethoxy-?-phenylethylamine in the mouse. https://app.cochat.ai/papers/10.1007/bf00421549
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- Korr, H., & Seiler, N. (1976). Autoradiographic studies on the distribution of 3H-2,3,4-trimethoxy-?-phenylethylamine in the mouse. Psychopharmacologia. https://doi.org/10.1007/bf00421549
