Longitudinal studies on the development of diabetes in individual Macaca nigra
Open accessAbstract
Development of spontaneous diabetes has been monitored in individual Macaca nigra. In this study, pancreatic biopsies were taken, islets were assessed morphologically, and results were related to the metabolic/clinical status. A biopsy or autopsy sample was obtained 4 to 10 years later, and the islet morphological state was again related to the metabolic/clinical status. Metabolic deterioration was correlated to the islet lesion, in which there was gradual loss of islet secretory cells and concurrent amyloid deposition. As nondiabetic monkeys with 0 to 3% islet amyloid progressed up to 20 to 40% amyloid, the insulin secretion and glucose clearance were both decreased (p less than or equal to 0.01), and the glucose and glucagon levels increased (p = 0.05). Impaired monkeys progressed to overt diabetes when islet amyloid exceeded 50 to 60%. Diabetic monkeys developed hyperglycaemia, along with impaired insulin secretion and glucose clearance (p less than 0.01). Loss of islet cells results in metabolic deterioration. The lesion precedes development of overt diabetes in Macaca nigra.
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Work on non-human primates and transgenic mice supports that islet amyloid deposition is an early event in the pathogenesis of Type 2 diabetes, associated with reductions in insulin release well before the onset of hyperglycaemia.
“Work done on non-human primates [136] and transgenic mice [137] support the concept that islet amyloid deposition is an early event in the pathogenesis of Type 2 diabetes being associated with reductions in insulin release well before the onset of hyperglycaemia.”
From The relative contributions of insulin resistance and beta-cell dysfunction to the pathophysiology of type 2 diabetes (2003) · cites this paper as [136]
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References 24 · Cited by 141
Research works printed but not linked: 1
- Mallory FB (ed) (1914) The principles of pathogenic histology. Saunders, Philadelphia, pp 519-530
- Authors
- Howard, C. F.
- Corresponding author
- Howard, Charles F.
- Venue
- Diabetologia
- Published
- 1986-05
- Volume
- 29
- Issue
- 5
- Pages
- 301-306
- ISSN
- 0012-186X (ISSN-L)
- 1432-0428
- OpenAlex
- W2034637066
- Cited by
- 141
- References
- 24
- Citations by year
- 2026: 1 · 2025: 1 · 2022: 2 · 2021: 2 · 2020: 1 · 2019: 2 · 2018: 5 · 2017: 8 · 2016: 2 · 2015: 5 · 2014: 2 · 2013: 3 · 2012: 2
- FWCI
- 9.15
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Licence
- www.springer.com/tdm (tdm)
- Locations
- Diabetologia (publishedVersion)
- PubMed (publishedVersion)
- Funders
- National Institutes of Health (5r01am021982-06, RR 00163)
- U.S. Public Health Service (RR-00163)
- National Center for Research Resources (RR-05694, RR-00163.)
- Topics
- Health Sciences › Medicine › Surgery › Pancreatic function and diabetes
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Diabetes and associated disorders
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Diabetes Treatment and Management
- Keywords
- spontaneous diabetes, Macaca nigra, rhesus monkeys, islet amyloid deposition, pancreatic islets, insulin secretion, glucose clearance, hyperglycemia, glucagon, pancreatic biopsy, diabetes progression, islet morphology
- MeSH terms
- Insulin Secretion, Amyloid, Animals, Blood Glucose, Diabetes Mellitus, Glucose Tolerance Test, Insulin, Islets of Langerhans, Longitudinal Studies, Macaca, Monkey Diseases
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