Effect of past and concurrent body mass index on prevalence of glucose intolerance and Type 2 (non-insulin-dependent) diabetes and on insulin response: The Israel study of glucose intolerance, obesity and hypertension
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A representative sample (n = 2140) of the Israeli Jewish population aged 40-70 (excluding known diabetic patients), whose body mass index had been measured 10 years earlier, underwent an oral glucose tolerance test and redetermination of body mass index. Irrespective of weight changes, high concurrent and high past body mass index values (greater than or equal to 27) were associated with similarly increased rates of glucose intolerance as compared with body mass index values less than 27 at both time-points (rate ratio 1.76, 90% confidence limits 1.56-1.99). Glucose intolerance here includes borderline and impaired tolerance as well as Type 2 diabetes. The rate of Type 2 diabetes increased only with increasing past body mass index, while concurrent body mass index had no effect [rate ratios: 2.36 (1.48-3.75) and 1.99 (1.48-2.68) respectively for the medium-(23-26.9) versus-low (less than 23) and high- (greater than or equal to 27) versus-medium past body-mass-index categories]. Weight reduction was associated with only slightly reduced rate of glucose intolerance and had no effect on the rate of diabetes. Mean sum insulin (summed 1 and 2 h levels, mU/l) increased significantly with increasing concurrent body mass index (123, 150 and 190 in the low, medium and high categories) with no effect of past body mass index. It also increased significantly (p less than 0.001) in all concurrent body mass index categories from normal tolerance through borderline to impaired tolerance, and decreased significantly (p less than 0.001) in diabetes relative to impaired tolerance, although it remained above normal.(ABSTRACT TRUNCATED AT 250 WORDS)
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Impaired fasting glycemia and impaired glucose tolerance are strong risk factors for type 2 diabetes.
“The latter two are strong risk factors for type 2 diabetes (1-6).”
From Role of Insulin Secretion and Sensitivity in the Evolution of Type 2 Diabetes in the Diabetes Prevention Program (2005) · cites this paper as [2]
The BMI INTERVAL section describes impaired glucose tolerance progressing to Type 2 diabetes, and the Discussion likewise describes worsening from impaired tolerance to diabetes. But the paper does not address impaired fasting glycemia or establish that both conditions are strong risk factors. Page numbers are unavailable in our copy. (LLM, conf=0.84)
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References 41 · Cited by 161
- Authors
- Modan, M., Karasik, A., Halkin, H., Fuchs, Z., Lusky, A., Shitrit, A., & Modan, B.
- Affiliations
- Tel Aviv University (IL)
- ORCID
- Shitrit, A.
- Venue
- Diabetologia
- Published
- 1986-02
- Volume
- 29
- Issue
- 2
- Pages
- 82-89
- ISSN
- 0012-186X (ISSN-L)
- 1432-0428
- OpenAlex
- W2885752447
- Cited by
- 161
- References
- 41
- Citations by year
- 2020: 1 · 2018: 2 · 2017: 1 · 2016: 3 · 2015: 1 · 2014: 5 · 2013: 5 · 2012: 3
- FWCI
- 8.38
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Licence
- www.springer.com/tdm (tdm)
- Locations
- Diabetologia (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Diabetes, Cardiovascular Risks, and Lipoproteins
- Health Sciences › Medicine › Public Health, Environmental and Occupational Health › Obesity, Physical Activity, Diet
- Health Sciences › Medicine › Epidemiology › Adipokines, Inflammation, and Metabolic Diseases
- Keywords
- body mass index, obesity, type 2 diabetes, impaired glucose tolerance, insulin response, weight loss, longitudinal follow-up, Israeli Jews, oral glucose tolerance test
- MeSH terms
- Adult, Aged, Analysis of Variance, Blood Glucose, Body Constitution, Body Height, Body Weight, Diabetes Mellitus, Type 2, Female, Glucose Tolerance Test, Humans, Hyperglycemia, Hypertension, Insulin, Israel, Male, Middle Aged, Obesity
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