Supersensitivity psychosis in schizophrenic patients after sudden clozapine withdrawal
Abstract
In two patients with chronic schizophrenia, who were on clozapine medication for more than 6 months, a sudden withdrawal of the drug resulted in a very pronounced deterioration of the psychosis within 24-48 h. The most prominent symptoms were auditory hallucinations and persecutory ideas and one patient tried to commit suicide. These observations are interpreted as supersensitivity psychoses induced by the very effective clozapine treatment.
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Esketamine has been marketed as a nasal spray approved by the FDA in 2019 for intranasal treatment of treatment-resistant depression in conjunction with an oral antidepressant.
“Esketamine, the enantiomer of ketamine and an NMDA receptor antagonist, has been marketed as nasal spray approved by the Food and Drug Administration (FDA) in 2019 for intranasal treatment of treatment-resistant depression in conjunction with an oral antidepressant [134, 135].”
From Acute and Persistent Withdrawal Syndromes Following Discontinuation of Psychotropic Medications (2020) · cites this paper as [135]
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References 8 · Cited by 88
- Authors
- Ekblom, B., Eriksson, K., & Lindstr�m, L. H.
- Affiliations
- Uppsala University Hospital (SE)
- Venue
- Psychopharmacology
- Published
- 1984-06
- Volume
- 83
- Issue
- 3
- Pages
- 293-294
- ISSN
- 0033-3158 (ISSN-L)
- 1432-2072
- OpenAlex
- W2007589067
- Cited by
- 88
- References
- 8
- Citations by year
- 2025: 1 · 2024: 1 · 2022: 1 · 2021: 3 · 2020: 2 · 2019: 3 · 2017: 3 · 2015: 3 · 2013: 4 · 2012: 1
- FWCI
- 2.16
- Type
- journal article
- Language
- en
- Open access
- closed
- Licence
- www.springer.com/tdm (tdm)
- Locations
- Psychopharmacology (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Psychiatry and Mental health › Schizophrenia research and treatment
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neurotransmitter Receptor Influence on Behavior
- Life Sciences › Neuroscience › Cognitive Neuroscience › Hallucinations in medical conditions
- Keywords
- clozapine, drug withdrawal, schizophrenia, auditory hallucinations, persecutory delusions, suicide attempts, antipsychotic adverse effects
- MeSH terms
- Adult, Clozapine, Dibenzazepines, Female, Humans, Male, Psychotic Disorders, Schizophrenia, Substance Withdrawal Syndrome
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