Evidence for an insulin resistance in the adult offspring of pregnant streptozotocin-diabetic rats
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Streptozotocin has been used to cause β-cell destruction in order to produce maternal insulin deficiency and hyperglycemia, though this more closely approximates type 1 diabetes.
“To model diabetes during pregnancy, streptozotocin (STZ) has been used to cause β-cell destruction in order to produce maternal insulin deficiency and hyperglycemia, though this more closely approximates type 1 diabetes [90,91,92].”
From Recent Experimental Studies of Maternal Obesity, Diabetes during Pregnancy and the Developmental Origins of Cardiovascular Disease (2022) · cites this paper as [91]
The Animals section reports that streptozotocin was injected on day one of pregnancy and that the rats became severely hyperglycaemic; the Results section also reports maternal hypoinsulinaemia. Our copy does not state that streptozotocin destroyed maternal β-cells or that this model more closely approximates type 1 diabetes. Its discussion of β-cell changes concerns the fetuses, not the mothers. Page numbers are unavailable in our copy. (LLM, conf=0.88)
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References 23 · Cited by 97
- Authors
- Holemans, K., Aerts, L., & Van Assche, F. A.
- Affiliations
- KU Leuven (BE)
- Venue
- Diabetologia
- Published
- 1991-02
- Volume
- 34
- Issue
- 2
- Pages
- 81-85
- ISSN
- 0012-186X (ISSN-L)
- 1432-0428
- OpenAlex
- W2093276224
- Cited by
- 97
- References
- 23
- Citations by year
- 2025: 1 · 2023: 1 · 2022: 1 · 2019: 2 · 2017: 1 · 2016: 2 · 2015: 3 · 2014: 1 · 2013: 1 · 2012: 3
- FWCI
- 1.07
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Licence
- www.springer.com/tdm (tdm)
- Locations
- Diabetologia (publishedVersion)
- PubMed (publishedVersion)
- Funders
- Centre National de la Recherche Scientifique
- Topics
- Health Sciences › Medicine › Pediatrics, Perinatology and Child Health › Birth, Development, and Health
- Health Sciences › Medicine › Obstetrics and Gynecology › Gestational Diabetes Research and Management
- Health Sciences › Medicine › Surgery › Pancreatic function and diabetes
- Keywords
- insulin resistance, streptozotocin-induced diabetes, diabetes in pregnancy, offspring of diabetic mothers, hyperinsulinemic-euglycemic clamp, glucose utilization, hepatic glucose production, insulin sensitivity, insulin responsiveness, glucose infusion rate, isotope dilution
- MeSH terms
- Animals, Blood Glucose, Body Weight, Diabetes Mellitus, Experimental, Fatty Acids, Nonesterified, Female, Glucagon, Insulin, Insulin Infusion Systems, Insulin Resistance, Pregnancy, Pregnancy in Diabetics, Rats, Inbred Strains, Reference Values, Glucose Clamp Technique, Rats
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