Genetic control of human apolipoprotein E polymorphism: Comparison of one-and two-dimensional techniques of isoprotein analysis
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The introduction of additional basic residues in apoE ɛ3 and apoE ɛ4 results in a shift in the isoelectric point of the proteins and was the basis of their nomenclature.
“The introductionof the additional basic residues in apoE ɛ3 and apoE ɛ4 results in a shift in the isoelectric point of the proteins and was the basis of their nomenclature [4, 5].”
From Discovery of a Missense Mutation (Q222K) of the <i>APOE</i> Gene from the Australian Imaging, Biomarker and Lifestyle Study (2023) · cites this paper as [4]
The mutation to arginine in apoE ɛ3 and ɛ4 produces one or two additional positive charges relative to apoE ɛ2 at biological pH.
“The mutation to arginine produces one or two additional positive charges relative to apoE ɛ2, at biological pH.”
From Discovery of a Missense Mutation (Q222K) of the <i>APOE</i> Gene from the Australian Imaging, Biomarker and Lifestyle Study (2023) · cites this paper as [4]
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References 33 · Cited by 149
- Authors
- Utermann, G., Steinmetz, A., & Weber, W.
- Affiliations
- Philipps University of Marburg (DE)
- Venue
- Human Genetics
- Published
- 1982
- Volume
- 60
- Issue
- 4
- Pages
- 344-351
- ISSN
- 0018-7348 (ISSN-L)
- 0340-6717
- 1432-1203
- OpenAlex
- W2067050771
- Cited by
- 149
- References
- 33
- Citations by year
- 2025: 1 · 2024: 1 · 2023: 1 · 2021: 1 · 2018: 2 · 2016: 2 · 2013: 2 · 2012: 1
- FWCI
- 15.50
- Type
- journal article
- Language
- en
- Open access
- closed
- Licence
- www.springer.com/tdm (tdm)
- Locations
- Human Genetics (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Surgery › Lipoproteins and Cardiovascular Health
- Health Sciences › Medicine › Physiology › Alzheimer's disease research and treatments
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Genetic Associations and Epidemiology
- Keywords
- apolipoprotein E, genetic polymorphism, apolipoprotein E isoforms, two-dimensional gel electrophoresis, isoelectric focusing, VLDL, neuraminidase treatment, sialic acid, allele frequency, family studies, genetic linkage, blood donors
- MeSH terms
- Alleles, Apolipoproteins, Apolipoproteins E, Blood Donors, Blood Protein Electrophoresis, Female, Gene Frequency, Genes, Dominant, Humans, Isoelectric Focusing, Lipoproteins, VLDL, Male, Neuraminidase, Phenotype, Polymorphism, Genetic, Apolipoprotein E3
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