Axonal injury: a universal consequence of fatal closed head injury?
Abstract
beta-Amyloid precursor protein immunostaining has recently been shown to be a reliable method for detecting the damage to axons associated with fatal head injury. In an attempt to compare the efficacy of this technique with conventional histological detection of axonal damage, we have reanalysed sections from a large well-characterised series of head-injured and control patients. The results indicate that the frequency of axonal injury has been vastly underestimated using conventional silver techniques, and that axonal injury may in fact be an almost universal consequence of fatal head injury.
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APP accumulates in traumatized axons after all severities of TBI and has been detected many months post-injury.
“For example, APP accumulates in traumatized axons after all severities of TBI and has been detected many months post-injury (129–131).”
From The Inflammatory Continuum of Traumatic Brain Injury and Alzheimer’s Disease (2018) · cites this paper as [131]
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References 34 · Cited by 296
- Authors
- Gentleman, S. M., Roberts, G. W., Gennarelli, T. A., Maxwell, W. L., Adams, J. H., Kerr, S., & Graham, D. I.
- Affiliations
- Charing Cross Hospital (GB)
- Hospital of the University of Pennsylvania (US)
- University of Glasgow (GB)
- Southern General Hospital (GB)
- Venue
- Acta Neuropathologica
- Published
- 1995
- Volume
- 89
- Issue
- 6
- Pages
- 537-543
- ISSN
- 0001-6322 (ISSN-L)
- 1432-0533
- OpenAlex
- W2076782787
- Cited by
- 296
- References
- 34
- Citations by year
- 2026: 4 · 2025: 6 · 2024: 8 · 2023: 8 · 2022: 7 · 2021: 8 · 2020: 7 · 2019: 7 · 2018: 8 · 2017: 6 · 2016: 4 · 2015: 12 · 2014: 8 · 2013: 9 · 2012: 11
- FWCI
- 8.54
- Type
- journal article
- Language
- en
- Open access
- closed
- Licence
- www.springer.com/tdm (tdm)
- Locations
- Acta Neuropathologica (publishedVersion)
- PubMed (publishedVersion)
- Funders
- Medical Research Council
- Topics
- Health Sciences › Medicine › Neurology › Traumatic Brain Injury and Neurovascular Disturbances
- Health Sciences › Medicine › Epidemiology › Traumatic Brain Injury Research
- Health Sciences › Medicine › Pulmonary and Respiratory Medicine › Automotive and Human Injury Biomechanics
- Keywords
- axonal injury, silver staining, traumatic brain injury
- MeSH terms
- Adolescent, Adult, Aged, Aged, 80 and over, Axons, Child, Child, Preschool, Female, Humans, Immunohistochemistry, Intracranial Pressure, Male, Middle Aged, Survival, Head Injuries, Closed, Amyloid beta-Protein Precursor, Silver Staining
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