The stimulus secretion coupling of glucose-induced insulin release: XXVII. Effect of glucose on K+ fluxes in isolated islets
Abstract
The effect of glucose upon the handling of K+ by islets of Langerhans removed from normal rats was investigated by measuring both the net uptake of 86Rb+ and its efflux from prelabelled islets. The inflow of K+ into islet cells is mediated, in part at least, by an ouabain-sensitive pump. Glucose fails to affect the inflow rate of K+, but it apparently decreases the permeability of islet cells plasma membrane to effuent K+. The glucose-induced change in permeability is a rapid and rapidly reversible phenomenon. Under steady-state conditions, it leads to an increase in the islet cells K+ pool and a decrease of its fractional turnover rate.
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The Na-K ATPase is highly expressed in the β-cell and accounts for as much as 75% of the β-cell's energy consumption.
“It is highly expressed and as much as 75% of the energy consumption of the β-cell is due to the operation of this pump (421).”
From Pancreatic β-Cell Electrical Activity and Insulin Secretion: Of Mice and Men (2018) · cites this paper as [421]
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Pancreatic β-Cell Electrical Activity and Insulin Secretion: Of Mice and Men
Rorsman, P., & Ashcroft, F. M. (2018) · Physiological Reviews · doi:10.1152/physrev.00008.2017 · Cited by 793 · see citing works
- Authors
- Malaisse, W. J., Boschero, A. C., Kawazu, S., & Hutton, J. C.
- Venue
- Pfl�gers Archiv European Journal of Physiology
- Published
- 1978-03
- Volume
- 373
- Issue
- 3
- Pages
- 237-242
- ISSN
- 0031-6768 (ISSN-L)
- 1432-2013
- OpenAlex
- W1974700532
- Cited by
- 124
- References
- 0
- Citations by year
- 2024: 1 · 2021: 2 · 2020: 1 · 2017: 1 · 2014: 1
- FWCI
- 29.05
- Type
- journal article
- Language
- en
- Open access
- closed
- Licence
- www.springer.com/tdm (tdm)
- Locations
- Pflügers Archiv - European Journal of Physiology (publishedVersion)
- PubMed (publishedVersion)
- Dépôt institutionnel de l'Université libre de Bruxelles (Université Libre de Bruxelles) (submittedVersion)
- Topics
- Health Sciences › Medicine › Surgery › Pancreatic function and diabetes
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Ion Transport and Channel Regulation
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Ion channel regulation and function
- Keywords
- glucose-stimulated insulin secretion, pancreatic islets, potassium uptake, potassium efflux, plasma membrane permeability, stimulus-secretion coupling
- MeSH terms
- Animals, Cell Membrane Permeability, Dose-Response Relationship, Drug, Female, Glucose, Islets of Langerhans, Ouabain, Potassium, Rubidium, Time Factors, Rats, In Vitro Techniques
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