Diffuse type of senile plaques in the brains of Alzheimer-type dementia
Abstract
We studied the nature of diffuse type of senile plaques (SP) in the brains of six autopsied subjects with Alzheimer-type dementia (ATD). The densities of SP in the entorhinal cortex were evaluated using serial sections stained by four different methods. Compared with beta protein immunostaining (100% as a reference), the modified Bielschowsky stain (103%) and the periodic acid-methenamine silver (PAM) stain (109%) labeled similar numbers of SP, whereas the Bodian stain labeled only a minor proportion (42%) of these. The vast majority of Bodian-negative plaques were diffuse plaques, which were seen as ill-defined areas of fine fibrillar material after beta protein immunostain with formic acid pretreatment, modified Bielschowsky stain, and PAM stain. They were not stained by Congo red or periodic acid-Schiff stains. Double staining using Bodian and beta protein methods demonstrated that diffuse plaques were free of swollen neurites. Argyrophilia of the diffuse plaques shown by the modified Bielschowsky and PAM stains, became undetectable when sections were pretreated with formic acid. Such treatment made the diffuse plaques immunoreactive to beta protein antiserum, suggesting that diffuse plaques consisted mainly of amyloid, but not neuritic components. The diffuse plaques were distributed in various cortical areas and in the amygdala, and comprised a considerable population of the SP in the ATD brains.
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Dense core plaques have dense reticular or radiating compact dense amyloid and are intensely positive with thioflavin S fluorescent microscopy and Congo red, suggesting they contain more fibrillogenic forms of Aβ.
“In comparison, dense core plaques have dense reticular or radiating compact dense amyloid and are intensely positive with thioflavin S fluorescent microscopy and Congo red, suggesting they contain more fibrillogenic forms of Aβ [29, 34, 35].”
From The neuropathological diagnosis of Alzheimer's disease (2019) · cites this paper as [35]
Immunocytochemical studies using antisera to Aβ have established that Aβ is deposited not only in neuritic plaques but also in large numbers of diffuse plaques.
“Immunocytochemical studies using antisera to A{3 have established that A(3 is deposited not only in neuritic plaques, which are spherical clusters of altered neurites that in some cases surround well defined amyloid cores, but also in large numbers of diffuse plaques, which are poorly circumscribed, immunoreactive lesions showing minimal neuritic change (1,2).”
From Amyloid β Protein (Aβ) in Alzheimeri's Disease Brain (1995) · cites this paper as [1]
In the brains of patients with Alzheimer's disease, amyloid composed of 4-kDa amyloid β protein (Aβ) is deposited in senile plaques and in blood vessel walls.
“In the brains of patients with Alzheimer's disease (AD),!amyloid composed of 4-kDa amyloid {3 protein (A{3) is deposited in senile plaques and in blood vessel walls.”
From Amyloid β Protein (Aβ) in Alzheimeri's Disease Brain (1995) · cites this paper as [1]
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References 24 · Cited by 235
- Authors
- Yamaguchi, H., Hirai, S., Morimatsu, M., Shoji, M., & Harigaya, Y.
- Affiliations
- Gunma University (JP)
- Venue
- Acta Neuropathologica
- Published
- 1988-03
- Volume
- 77
- Issue
- 2
- Pages
- 113-119
- ISSN
- 0001-6322 (ISSN-L)
- 1432-0533
- OpenAlex
- W1239531603
- Cited by
- 235
- References
- 24
- Citations by year
- 2026: 2 · 2025: 3 · 2024: 11 · 2023: 2 · 2022: 4 · 2021: 2 · 2020: 3 · 2019: 4 · 2018: 1 · 2017: 1 · 2016: 5 · 2015: 3 · 2014: 3 · 2013: 3 · 2012: 2
- FWCI
- 14.45
- Type
- journal article
- Language
- en
- Open access
- closed
- Licence
- Locations
- Acta Neuropathologica (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Physiology › Alzheimer's disease research and treatments
- Health Sciences › Medicine › Psychiatry and Mental health › Dementia and Cognitive Impairment Research
- Life Sciences › Neuroscience › Neurology › Neuroinflammation and Neurodegeneration Mechanisms
- Keywords
- Alzheimer-type dementia, amyloid plaques, entorhinal cortex, amyloid-beta, Congo red, periodic acid-Schiff reaction, formic acid pretreatment, amygdala
- MeSH terms
- Aged, Aged, 80 and over, Alzheimer Disease, Amyloid, Brain, Humans, Immunohistochemistry, Middle Aged, Staining and Labeling, Amyloid beta-Peptides
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