Spine distribution along the apical dendrites of the pyramidal neurons in Down's syndrome: A quantitative golgi study
Abstract
The number of spines along the apical dendrites of the pyramidal neurons in the hippocampal and cingulate gyri were counted on Golgi preparations of the brains of seven cases of Down's syndrome; they did not show neuropathological senile changes. The number of spines in the middle and distal segments of the apical dendrites of Down's syndrome group were significantly fewer than in those of the control group. The number of spines in aged noncharacteristic mentally retarded cases were not decreaed compared with the controls. The diminution of spines in Down's syndrome is considered to be rather specific in this condition and is not a common finding in other types of mental retardation. It might also be one of the early changes of dendritic degeneration related to senile plaque formation.
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A decreased number of dendritic spines on pyramidal neurons were found in children and young adults (3-23 years) with Down syndrome compared to age matched controls.
“a decreased number of dendritic spines on pyramidal neurons were found both in children and young adults (3–23 years) (Suetsugu and Mehraein, 1980)”
From Neurodevelopment in Down syndrome: Concordance in humans and models (2022) · cites this paper as Suetsugu and Mehraein, 1980
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References 29 · Cited by 190
- Authors
- Suetsugu, M., & Mehraein, P.
- Affiliations
- Kyushu University (JP)
- Medizinische Hochschule Hannover (DE)
- Venue
- Acta Neuropathologica
- Published
- 1980
- Volume
- 50
- Issue
- 3
- Pages
- 207-210
- ISSN
- 0001-6322 (ISSN-L)
- 1432-0533
- OpenAlex
- W2887232778
- Cited by
- 190
- References
- 29
- Citations by year
- 2026: 2 · 2025: 6 · 2024: 6 · 2023: 6 · 2022: 5 · 2021: 6 · 2020: 2 · 2019: 3 · 2018: 2 · 2017: 11 · 2016: 2 · 2015: 5 · 2014: 4 · 2013: 8 · 2012: 5
- FWCI
- 7.03
- Type
- journal article
- Language
- en
- Open access
- closed
- Licence
- www.springer.com/tdm (tdm)
- Locations
- Acta Neuropathologica (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Public Health, Environmental and Occupational Health › Down syndrome and intellectual disability research
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Genetics and Neurodevelopmental Disorders
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
- Keywords
- Down syndrome, dendritic spines, apical dendrites, pyramidal neurons, hippocampus, cingulate gyrus, dendritic degeneration, amyloid plaques, intellectual disability, Golgi staining
- MeSH terms
- Adolescent, Adult, Aged, Cerebral Cortex, Child, Child, Preschool, Dendrites, Down Syndrome, Female, Hippocampus, Humans, Male, Intellectual Disability, Microscopy, Electron
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