The perineuronal satellite oligodendrocyte: A role in remyelination
Abstract
Demyelination was induced in the superior cerebellar peduncles of weanling mice by the administration of Cuprizone. Remyelination occurred when the animals were replaced on a normal diet. Perineuronal satellite oligodendrocytes in the periventricular gray were clearly seen to be remyelinating axons. This study demonstrates for the first time the role of these cells in remyelination, and raises the possibility that they may be involved in normal myelination of the central nervous system.
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Data from the cuprizone mouse model and in vivo imaging suggest that satellite oligodendrocytes can generate compact myelin around pyramidal neurons of mouse layer V.
“data from the cuprizone mouse model and in vivo imaging suggests that these cells can generate compact myelin around pyramidal neurons of mouse layer V.54,55”
From BCAS1-positive oligodendrocytes enable efficient cortical remyelination in multiple sclerosis (2025) · cites this paper as [55]
Cites
Demyelination of the superior cerebellar peduncle in the mouse induced by cuprizone
Blakemore, W. F. (1973) · Journal of the Neurological Sciences · doi:10.1016/0022-510x(73)90118-4 · Cited by 207 · see citing works
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The genetic signature of perineuronal oligodendrocytes reveals their unique phenotype
Szuchet, S., Nielsen, J. A., Lovas, G., Domowicz, M. S., de Velasco, J. M., Maric, D., & Hudson, L. D. (2011) · European Journal of Neuroscience · doi:10.1111/j.1460-9568.2011.07922.x · Cited by 53 · see citing works
BCAS1-positive oligodendrocytes enable efficient cortical remyelination in multiple sclerosis
Bergner, C. G., van der Meer, F., Franz, J., Vakrakou, A., Würfel, T., Nessler, S., Schäfer, L., Nau-Gietz, C., Winkler, A., Lagumersindez-Denis, N., et al. (2025) · Brain · doi:10.1093/brain/awae293 · Cited by 16 · see citing works
“…the cuprizone mouse model and in vivo imaging suggests that these cells can generate compact myelin around pyramidal neurons of mouse layer V. 54,55 Importantly, satellite oligodendrocytes sense neuronal electric and metabolic activity, thus putting them into an ideal position to react rapidly…”
- Authors
- Ludwin, S. K.
- Affiliations
- Queen's University (CA)
- Corresponding author
- Ludwin, S. K.
- Venue
- Acta Neuropathologica
- Published
- 1979
- Volume
- 47
- Issue
- 1
- Pages
- 49-53
- ISSN
- 0001-6322 (ISSN-L)
- 1432-0533
- OpenAlex
- W2082578555
- Cited by
- 75
- References
- 1
- Citations by year
- 2026: 1 · 2025: 2 · 2024: 3 · 2023: 2 · 2020: 2 · 2019: 4 · 2018: 6 · 2017: 4 · 2016: 2 · 2015: 1 · 2014: 2 · 2013: 1 · 2012: 1
- FWCI
- 0.16
- Type
- journal article
- Language
- en
- Open access
- closed
- Licence
- www.springer.com/tdm (tdm)
- Locations
- Acta Neuropathologica (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Life Sciences › Neuroscience › Developmental Neuroscience › Neurogenesis and neuroplasticity mechanisms
- Health Sciences › Medicine › Pathology and Forensic Medicine › Multiple Sclerosis Research Studies
- Life Sciences › Neuroscience › Neurology › Neuroinflammation and Neurodegeneration Mechanisms
- Keywords
- oligodendrocytes, remyelination, demyelination, cuprizone, superior cerebellar peduncle, periventricular gray, myelination, central nervous system
- MeSH terms
- Animals, Axons, Brain, Male, Microscopy, Electron, Myelin Sheath, Neuroglia, Oligodendroglia, Mice
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