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In vivo efficacy of albendazole againstGiardia duodenalis in mice
Abstract
The antigiardial effects of albendazole were demonstrated in vivo using experimental infections of Giardia duodenalis in mice. These results complement previous in vivo studies in which albendazole was shown to have more potent antigiardial action than the currently applied antigiardial drugs. In mice, 2-4 doses (greater than 100 mg/kg twice daily) were required for complete inhibition of cyst excretion and full elimination of trophozoites from the small intestine. The high doses necessary in mice were not unexpected and are discussed in light of the possible pharmacokinetics of albendazole in the animal model used in this study.
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Albendazole is active against G. duodenalis in vivo in mice and dogs.
“It was also shown that albendazole is active against G. duodenalis in vivo of mice [268] and dogs [269].”
From Albendazole and Mebendazole as Anti-Parasitic and Anti-Cancer Agents: an Update (2021) · cites this paper as [268]
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Research works printed but not linked: 19
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Albendazole and Mebendazole as Anti-Parasitic and Anti-Cancer Agents: an Update
Chai, J.-Y., Jung, B.-K., & Hong, S.-J. (2021) · The Korean Journal of Parasitology · doi:10.3347/kjp.2021.59.3.189 · Cited by 286
Metadata
- Authors
- Reynoldson, J. A., Thompson, R. C. A., & Meloni, B. P.
- Affiliations
- Murdoch University (AU)
- ORCID
- Meloni, B. P.
- Venue
- Parasitology Research
- Published
- 1991
- Volume
- 77
- Issue
- 4
- Pages
- 325-328
- ISSN
- 0044-3255 (ISSN-L)
- 1432-1955
- OpenAlex
- W2087816818
- Cited by
- 38
- References
- 0
- Citations by year
- 2025: 2 · 2021: 3 · 2020: 2 · 2019: 1 · 2017: 1 · 2015: 1 · 2014: 2 · 2012: 1
- FWCI
- 2.10
- Type
- journal article
- Language
- en
- Open access
- closed
- Licence
- www.springer.com/tdm (tdm)
- Locations
- Parasitology Research (publishedVersion)
- PubMed (publishedVersion)
- Murdoch University Research Portal (submittedVersion)
- Topics
- Life Sciences › Immunology and Microbiology › Parasitology › Parasitic Infections and Diagnostics
- Life Sciences › Immunology and Microbiology › Parasitology › Helminth infection and control
- Health Sciences › Medicine › Infectious Diseases › Amoebic Infections and Treatments
- Keywords
- albendazole, Giardia lamblia, giardiasis, pharmacokinetics, drug dosing, experimental infection in mice
- MeSH terms
- Animals, Disease Models, Animal, Dose-Response Relationship, Drug, Giardia, Giardiasis, Intestine, Small, Albendazole, Mice
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