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Simultaneous expression by porcine aorta endothelial cells of glycosphingolipids bearing the major epitope for human xenoreactive antibodies (Gal?1?3Gal), blood group H determinant andN-glycolylneuraminic acid
Abstract
Glycosphingolipids were isolated from primary cultures of porcine endothelial cells labelled with 14C-galactose or 14C-glucosamine. They were characterized by their mobility on thin layer chromatogram, their sensitivity to exoglycosidases, and their labelling with antibodies. In addition to the major glycosphingolipids, globotetra- and globotriaosylceramide, minor ones were identified as penta- and heptaglycosylceramide of the neolactoseries terminated by either Gal alpha 1-3Gal- (xenoreactive epitope) or Fuc alpha 1-2Gal- (H determinant). Two gangliosides were found, GM3 and GD3, and N-glycolylneuraminic acid was their major sialic acid. Therefore, porcine endothelial cells differ from human endothelial cells by expression of glycosphingolipids that are absent in man: two Gal alpha 1-3Gal-terminated glycolipids recognized by human natural antibodies, and two N-glycolylneuraminic acid-terminated gangliosides which are potent immunogens.
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“After birth, humans develop antibodies to α-Gal and Neu5Gc, referred to as preformed antibodies, upon exposure to molecular mimics of these two antigens16,20,21.”
From Design and testing of a humanized porcine donor for xenotransplantation (2023) · cites this paper as [16]
In the citing paper
“Porcine cells display three major glycan antigens on their cell surface — α-Gal15, Neu5Gc16 and Sd(a)17 (Fig. 1a) — which are the products of the corresponding glycan synthesis genes, glycoprotein α-galactosyltransferase 1 (GGTA1), cytidine monophospho-N-acetylneuraminic acid hydroxylase (CMAH) and β-1,4-N-acetyl-galactosaminyltransferase 2 (B4GALNT2)/B4GALNT2-like (B4GALNT2L).”
From Design and testing of a humanized porcine donor for xenotransplantation (2023) · cites this paper as [16]
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Sorted by citations
Design and testing of a humanized porcine donor for xenotransplantation
Anand, R. P., Layer, J. V., Heja, D., Hirose, T., Lassiter, G., Firl, D. J., Paragas, V. B., Akkad, A., Chhangawala, S., Colvin, R. B., et al. (2023) · Nature · doi:10.1038/s41586-023-06594-4 · Cited by 302
Modifying the sugar icing on the transplantation cake
Cooper, D. K. C. (2016) · Glycobiology · doi:10.1093/glycob/cww028 · Cited by 36
Metadata
- Authors
- Bouhours, D., Pourcel, C., & Bouhours, J.-F.
- Venue
- Glycoconjugate Journal
- Published
- 1996-12
- Volume
- 13
- Issue
- 6
- Pages
- 947-953
- ISSN
- 0282-0080
- 1573-4986
- Cited by
- 113
- References
- 0
- Language
- en
- Licence
- www.springer.com/tdm (tdm)
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