Hepatic clearance of drugs. II. Experimental evidence for acceptance of the “well-stirred” model over the “parallel tube” model using lidocaine in the perfused rat liverin situ preparation
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Using lidocaine with an ER of 0.99 or higher in mice liver perfusion, its metabolite profile is well described by the well-stirred model.
“using lidocaine with an ER of 0.99 or higher, a liver perfusion experiment was conducted in mice. Its metabolite profile is well described by the well-stirred model.”
From Interpretation of Non-Clinical Data for Prediction of Human Pharmacokinetic Parameters: In Vitro-In Vivo Extrapolation and Allometric Scaling (2019) · cites this paper as [43]
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References 29 · Cited by 217
- Authors
- Pang, K. S., & Rowland, M.
- Affiliations
- University of California, San Francisco (US)
- ORCID
- Pang, K. Sandy
- Venue
- Journal of Pharmacokinetics and Biopharmaceutics
- Published
- 1977-12
- Volume
- 5
- Issue
- 6
- Pages
- 655-680
- ISSN
- 0090-466X (ISSN-L)
- OpenAlex
- W2078719547
- Cited by
- 217
- References
- 29
- Citations by year
- 2026: 3 · 2025: 4 · 2024: 5 · 2023: 8 · 2022: 5 · 2021: 6 · 2020: 5 · 2019: 6 · 2018: 5 · 2017: 5 · 2016: 1 · 2015: 3 · 2014: 3 · 2013: 6 · 2012: 1
- FWCI
- 3.01
- Type
- journal article
- Language
- en
- Open access
- closed
- Licence
- www.springer.com/tdm (tdm)
- Locations
- Journal of Pharmacokinetics and Biopharmaceutics (publishedVersion)
- PubMed (publishedVersion)
- Funders
- Merck
- Topics
- Life Sciences › Pharmacology, Toxicology and Pharmaceutics › Pharmacology › Pharmacogenetics and Drug Metabolism
- Life Sciences › Pharmacology, Toxicology and Pharmaceutics › Pharmacology › Drug-Induced Hepatotoxicity and Protection
- Health Sciences › Medicine › Oncology › Drug Transport and Resistance Mechanisms
- Keywords
- hepatic clearance, well-stirred model, parallel tube model, lidocaine, antipyrine, hepatic blood flow, extraction ratio
- MeSH terms
- Animals, Kinetics, Lidocaine, Liver, Models, Biological, Rats
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Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
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