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DNA cytosine methylation and heat-induced deamination
Abstract
The heat-induced conversion of 5-methylcytosine (m5C) residues to thymine residues and of cytosine to uracil residues in single-stranded DNA was studied. The calculated rates for deamination at 37°C and pH 7.4 were ∼9.5×10−10 and 2.1×10−10 sec−1, respectively. N4-Methyldeoxycytidine, which is in the DNA of certain thermophilic bacteria, was more heat-resistant than was deoxycytidine and much more than was 5-methyldeoxycytidine. Thermophilic bacteria which contain N4-methylcytosine rather than m5C in their genomes may thereby largely avoid heat-induced mutation due to deamination, which is incurred by the many organisms that contain m5C in their DNA.
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Cited by
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The stability of the RNA bases: implications for the origin of life
Levy, M., & Miller, S. L. (1998) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.95.14.7933 · Cited by 297
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Considerations for the Terminal Sterilization of Oligonucleotide Drug Products
Decollibus, D. P., Searcy, J., Tivesten, A., Akhtar, N., Lindenberg, C., Abarrou, N., Pradhan, S., Fiandaca, M., Franklin, J., Govindan, G., et al. (2023) · Nucleic Acid Therapeutics · doi:10.1089/nat.2022.0073 · Cited by 17
Metadata
- Authors
- Ehrlich, M., Norris, K. F., Wang, R. Y., Kuo, K. C., & Gehrke, C. W.
- Venue
- Bioscience Reports
- Publisher
- Portland Press Ltd.
- Published
- 1986-04-01
- Volume
- 6
- Issue
- 4
- Pages
- 387-393
- ISSN
- 0144-8463 (ISSN-L)
- 1573-4935
- OpenAlex
- W2072767862
- Cited by
- 175
- References
- 0
- FWCI
- 0.69
- Type
- journal article
- Language
- en
- Open access
- closed
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- CoChat. (2026). Citation check: DNA cytosine methylation and heat-induced deamination. https://app.cochat.ai/papers/10.1007/bf01116426
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- Ehrlich, M., Norris, K. F., Wang, R. Y., Kuo, K. C., & Gehrke, C. W. (1986). DNA cytosine methylation and heat-induced deamination. Bioscience Reports. https://doi.org/10.1007/bf01116426
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
