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Development of spare human preimplantation embryos in vitro: An analysis of the correlations among gross morphology, cleavage rates, and development to the blastocyst

Bolton, Virginia N., Hawes, Susan M., Taylor, Clare T., Parsons, John H.·1989·Journal of In Vitro Fertilization and Embryo Transfer
DOI 10.1007/bf01134578
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Abstract

Following in vitro fertilization, the criteria commonly used to select human embryos for transfer are the cleavage rate and gross morphology, the contention being that those embryos which divide more rapidly and have regular, spherical blastomeres are more likely to lead to a pregnancy. In order to assess the validity of this assumption, the development in vitro of spare embryos was investigated. Eggs and embryos were cultured in Earle's balanced salt solution containing 10% heat-inactivated patient's serum, and insemination was performed at 40 hr post human chorionic gonadotropin (hCG). At 82-90 hr post hCG, up to four embryos were transferred. Any spare embryos were cultured in the same medium for up to 6 days and scored daily for cell number and morphology using a "quality" scale of 4-1 according to degree of fragmentation and shape of the blastomeres. Of 317 fertilized eggs, 55 (17%) developed to the fully expanded blastocyst stage. The remaining embryos ceased development at the one-cell (6; 2%), two-cell (49; 15%), four-cell (110; 35%), eight-cell (61; 19%), and cavitating morula (36; 11%) stages. The relationship between developmental arrest and gross morphology is discussed.

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Crossref · 10.1007/bf01134578

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  • Unhealthy zygotes may develop more slowly, or implantation may be abnormal, resulting in later and weaker production of chorionic gonadotropin.

    “Unhealthy zygotes may develop more slowly, or implantation may be abnormal, 31 resulting in later and weaker production of chorionic gonadotropin.32”

    From Time of Implantation of the Conceptus and Loss of Pregnancy (1999) · cites this paper as [31]

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Research works printed but not linked: 20

  1. Braude PR, Bolton VN, Johnson MH: The use of human pre-embryos for infertility research.In Ciba Foundation Study Group: Research on Early Human Pre-embryos. London, Tavistock, 1986, pp 63?82
  2. Trounson AO, Mohr LR, Wood C, Leeton JF: Effect of delayed insemination onin vitro fertilisation, culture and transfer of human embryos. J Reprod Fert 1982;64:285?294 · DOI
  3. Mohr LR, Trounson AO, Leeton JF, Wood C: Evaluation of normal and abnormal human embryo development during proceduresin vitro.In Fertilisation of the Human Eggin Vitro: Biological Basis and Clinical Applications, HM Beier, HR Lindner (eds). Berlin, Springer-Verlag, 1983, pp 211?221 · DOI
  4. Mohr LR, Trounson AO:In vitro fertilisation and embryo growth.In Clinicalin vitro Fertilisation, C Wood, AO Trounson (eds). Berlin, Springer-Verlag, 1984, pp 99?115 · DOI
  5. Ball GD, Coulam CB, Field CS, Harms RW, Thie JT, Byers AP: Effect of serum source on human fertilisation and embryonic growth parametersin vitro. Fertil Steril 1985;44:75?79 · DOI
  6. Sauer MV, Bustillo M, Rodi IA, Gorrill MJ:In vivo blastocyst production and ovum yield among fertile women. Hum Reprod 1987;2:701?703 · DOI
  7. Buster JE, Bustillo M, Rodi IA, Cohen SW, Hamilton M, Simon JA, Thorneycroft IH, Marshall JR: Biologic and morphologic development of donated human ova recovered by non-surgical uterine lavage. Am J Obstet Gynecol 1985; 153:211?217 · DOI
  8. Schlesselman JJ: How does one assess the risk of abnormalities from human in vitro fertilisation? Am J Obstet Gynecol 1979;135:135?148 · DOI
  9. Pike IL: Biological risks ofin vitro fertilisation and embryo transfer.In ClinicalIn Vitro Fertilisation, C Wood, AO Trounson (eds). Berlin, Springer-Verlag, 1984, pp 137?146 · DOI
  10. O'Neill C, Gidley-Baird AA, Pike IL, Porter RN, Sinosich MJ, Saunders DM: Maternal blood platelet physiology and luteal phase endocrinology as a means of monitoring pre- and post-implantation embryo viability followingin vitro fertilisation. J In Vitro Fert Embryo Transfer 1985;2:87?93 · DOI
  11. Leese HJ, Hooper MAK, Edwards RG, Ashwood-Smith MJ: Uptake of pyruvate by early human embryos determined by a non-invasive technique. Hum Reprod 1986;1:181?182 · DOI
  12. Cummins JM, Breen TM, Harrison KL, Shaw JM, Wilson LM, Hennessey JF: A formula for scoring human embryo growth rates in in vitro fertilization: Its value in predicting pregnancy and in comparison with visual estimates of embryo quality. J Vitro Fert Embryo Transfer 1986;3:284?295 · DOI
  13. Claman P, Randall Armant D, Seibel MM, Wang T, Oskowitz SP, Taymoor MI: The impact of embryo quality and quantity on implantation and the establishment of viable pregnancies. J Vitro Fert Embryo Transfer 1987;4:218?222 · DOI
  14. Puissant F, Rysselberge M, Barlow P, Deweze J, Leroy F: Embryo scoring as a prognostic tool in IVF treatment. Hum Reprod 1987;2:705?708 · DOI
  15. Parsons J, Mason B, Campbell S, Whitehead MI: Ultrasound directed oocyte recovery.In Foundations of In Vitro Fertilisation, CM Fredericks, JD Poulson, AH DeCherney (eds). Washington, DC, Hemisphere, 1987, pp 125?132
  16. Hillier SG, Parsons JH, Margara RA, Winston RML, Crofton ME: Serum oestradiol and preovulatory follicular development before in-vitro fertilisation. J Endocrinol 1984;101:113?118 · DOI
  17. Lopata A, Patullo MJ, Chang A, James B: A method for collecting motile spermatozoa from human semen. Fertil Steril 1976;27:677?684 · DOI
  18. Tesarik J, Kopecny V, Plachot M, Mandelbaum J, DeLage C, Flechon J-E: Nucleologenesis in the human embryo developingin vitro: Ultrastructural and autoradiographic analysis. Dev Biol 1986;115:193?203 · DOI
  19. Tesarik J, Kopecny V, Plachot M, Mandelbaum J: Activation of nucleolar and extranucleolar RNA synthesis and changes in the ribosomal content of human embryos developingin vitro. J Reprod Fert 1986;78:463?470 · DOI
  20. Braude P, Bolton V, Moore S: Human gene expression first occurs between the four- and eight-cell stages of preimplantation development. Nature 1988;332:459?461 · DOI

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Metadata

Authors
Bolton, V. N., Hawes, S. M., Taylor, C. T., & Parsons, J. H.
Venue
Journal of In Vitro Fertilization and Embryo Transfer
Publisher
Springer Science and Business Media LLC
Published
1989-02
Volume
6
Issue
1
Pages
30-35
ISSN
  • 0740-7769
  • 1573-7330
DOI
10.1007/bf01134578
Cited by
183
References
0
Language
en
Licence
www.springer.com/tdm (tdm)

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