Hypogonadotropic hypogonadal men respond less well to androgen substitution treatment than hypergonadotropic hypogonadal men
Abstract
This research asked whether androgen substitution therapy is as efficacious in hypogonadotropic hypogonadal men as in hypergonadotropic hypogonadal men. Erotosexual functions of two groups of six men of each diagnostic category were compared after 5-6 years of continuous androgen treatment. Treatment regimen was the same in both groups: Parenteral testosterone esters 250 mg/2 weeks. No difference was found in erectile and ejaculatory potency, but the number of sexual acts and scores of subjective quality of sexual acts, sexual excitement, and frequency of sexual thoughts and of nonsexual parameters as vigor, fatigue, anxiety were more negative in the hypogonadotropic men. The most obvious difference between the two groups is the value of LH/FSH and presumably of LHRH. Hypogonadotropic hypogonadal men may be better treated with gonadotropins (or with pulsatile LHRH, when the hypophysis is intact) than with androgens.
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In hypogonadal teenage males, boys with primary hypogonadism showed less response to testosterone replacement than boys with secondary hypogonadism.
“Gooren (1988), in a study of hypogonadal teenage males, found that boys with primary hypogonadism showed less response to testosterone replacement than boys with secondary hypogonadism.”
From The endocrinology of sexual arousal (2005) · cites this paper as Gooren (1988)
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The endocrinology of sexual arousal
Bancroft, J. (2005) · Journal of Endocrinology · doi:10.1677/joe.1.06233 · Cited by 398 · see citing works
- Authors
- Gooren, L.
- Affiliations
- Amsterdam UMC Location Vrije Universiteit Amsterdam (NL)
- Corresponding author
- Gooren, Louis
- ORCID
- Gooren, Louis
- Venue
- Archives of Sexual Behavior
- Published
- 1988-06
- Volume
- 17
- Issue
- 3
- Pages
- 265-270
- ISSN
- 0004-0002 (ISSN-L)
- 1573-2800
- OpenAlex
- W1975819794
- Cited by
- 20
- References
- 0
- Citations by year
- 2018: 1 · 2017: 1 · 2014: 1 · 2012: 1
- FWCI
- 0.30
- Type
- journal article
- Language
- en
- Open access
- closed
- Licence
- www.springer.com/tdm (tdm)
- Locations
- Archives of Sexual Behavior (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Hormonal and reproductive studies
- Health Sciences › Medicine › Psychiatry and Mental health › Sexual function and dysfunction studies
- Health Sciences › Medicine › Reproductive Medicine › Hypothalamic control of reproductive hormones
- Keywords
- hypogonadotropic hypogonadism, hypergonadotropic hypogonadism, testosterone esters, erectile function, ejaculatory function, sexual behavior, LH/FSH ratio, luteinizing hormone, gonadotropin therapy, male sexual function
- MeSH terms
- Adolescent, Adult, Affect, Androgens, Ejaculation, Gonadotropins, Pituitary, Humans, Hypogonadism, Gonadotropin-Releasing Hormone, Male, Penile Erection, Sexual Behavior
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