On the rate of molecular evolution
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Kimura and Ohta explained the constant characteristic rate for each protein by suggesting that most amino-acid changes in a protein were effectively neutral.
“Motoo Kimura and Tomoko Ohta 4 explained the constant characteristic rate for each protein by suggesting that most amino-acid changes in a protein were effectively neutral - that is, changing the amino-acid sequence had no influence on the fitness of an organism and,therefore, the rate of change was not affected by natural selection.”
From The modern molecular clock (2003) · cites this paper as [4]
The citation lists haven’t been fetched yet
References 48 · Cited by 195
- Authors
- Kimura, M., & Ohta, T.
- Affiliations
- National Institute of Genetics (JP)
- Venue
- Journal of Molecular Evolution
- Published
- 1971-03
- Volume
- 1
- Issue
- 1
- Pages
- 1-17
- ISSN
- 0022-2844 (ISSN-L)
- 1432-1432
- OpenAlex
- W1974647439
- Cited by
- 195
- References
- 48
- Citations by year
- 2026: 8 · 2025: 5 · 2024: 9 · 2023: 17 · 2022: 6 · 2021: 5 · 2020: 3 · 2019: 6 · 2018: 3 · 2017: 3 · 2016: 3 · 2015: 2 · 2014: 4 · 2013: 6 · 2012: 3
- FWCI
- 10.31
- Type
- journal article
- Language
- en
- Open access
- closed
- Licence
- www.springer.com/tdm (tdm)
- Locations
- Journal of Molecular Evolution (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Evolution and Genetic Dynamics
- Physical Sciences › Earth and Planetary Sciences › Paleontology › Evolution and Paleontology Studies
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Genomics and Phylogenetic Studies
- Keywords
- molecular evolution rate, substitution rate, mutation rate, effective population size, natural selection, amino acid substitutions, protein evolution, living fossils, population dynamics
- MeSH terms
- Amino Acid Sequence, Biological Evolution, Gene Frequency, Genes, Genetics, Population, Models, Biological, Mutation
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
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