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Tumor localization with18F-2-fluoro-2-deoxy-D-glucose: Comparative autoradiography, glucose 6-phosphatase histochemistry, and histology of renally implanted sarcoma of the rat
Abstract
Rous sarcoma cells were implanted into the kidney of rats. After 5 days of growth the renal tumor was used for comparing histology with glucose 6-phosphatase (G6Pase) enzyme histochemistry (EHC) and 18F-fluoro-2-deoxyglucose (FDG) auroradiography (ARG). It was found that the regions of the kidney tumor that had retained normal kidney structures were devoid of FDG, whereas there was histochemical staining of normal cortical areas. Regions of tumor growth, on the other hand, retained FDG and lacked G6Pase. Necrotic areas did not accumulate FDG. There was a dramatic decrease in the areas of G6Pase activity as a result of tumor infiltration in the kidney. The results show that FDG, currently being evaluated as a tumor detecting radiopharmaceutical indeed accumulates into areas of vital malignant growth, and they indicate that FDG positron emission tomographic (PET) images reveal the true anatomic location of malignant tissue.
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“[18F]FDG uptake in tumors, inflammatory cells and brain tissue is mainly brought about by insulin-independent glucose transporters (GLUT) 1 or 3 [13,14,15,16,17,18,19].”
From Influences on PET Quantification and Interpretation (2022) · cites this paper as [17]
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References 25 · Cited by 32
Metadata
- Authors
- Paul, R., Johansson, R., Kellokumpu-Lehtinen, P. L., Söderström, K. O., & Kangas, L.
- Affiliations
- Turku University Hospital (FI)
- Kuopio University Hospital (FI)
- Venue
- Research In Experimental Medicine
- Published
- 1985-03
- Volume
- 185
- Issue
- 2
- Pages
- 87-94
- ISSN
- 0300-9130 (ISSN-L)
- 1433-8580
- OpenAlex
- W1990237267
- Cited by
- 32
- References
- 25
- Citations by year
- 2025: 1 · 2022: 2 · 2021: 1 · 2020: 3 · 2018: 1
- FWCI
- 2.66
- Type
- journal article
- Language
- en
- Open access
- closed
- Licence
- www.springer.com/tdm (tdm)
- Locations
- Research in Experimental Medicine (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Radiology, Nuclear Medicine and Imaging › Medical Imaging Techniques and Applications
- Health Sciences › Medicine › Radiology, Nuclear Medicine and Imaging › Radiopharmaceutical Chemistry and Applications
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Cancer Research › Cancer, Hypoxia, and Metabolism
- Keywords
- Rous sarcoma, renal sarcoma, tumor localization, tumor necrosis, tumor infiltration, positron emission tomography, tumor imaging, rat model
- MeSH terms
- Animals, Autoradiography, Sarcoma, Avian, Deoxy Sugars, Deoxyglucose, Glucose-6-Phosphatase, Kidney, Kidney Neoplasms, Liver, Male, Rats, Inbred Strains, Fluorodeoxyglucose F18, Rats
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- CoChat. (2026). Citation check: Tumor localization with18F-2-fluoro-2-deoxy-D-glucose: Comparative autoradiography, glucose 6-phosphatase histochemistry, and histology of renally implanted sarcoma of the rat. https://app.cochat.ai/papers/10.1007/bf01854893
- The paper
- Paul, R., Johansson, R., Kellokumpu-Lehtinen, P. L., Söderström, K. O., & Kangas, L. (1985). Tumor localization with18F-2-fluoro-2-deoxy-D-glucose: Comparative autoradiography, glucose 6-phosphatase histochemistry, and histology of renally implanted sarcoma of the rat. Research In Experimental Medicine. https://doi.org/10.1007/bf01854893
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
