The DOI matches its Crossref record; 13 of the 13 references it cites were found in a registry or an index.
Penicillin concentrations in blood and spinal fluid after a single intramuscular injection of penicillin G benzathine.
Abstract
The concentration of penicillin in cerebrospinal fluid and blood was measured after a single i.m. injection of 1.44 g penicillin G benzathine in 18 individuals (4 with neurosyphilis and 14 with neurological symptoms but not syphilis). Only one person had a treponemicidal concentration in the cerebrospinal fluid.
Overview
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
In the citing paper
“Pharmacologic considerations indicate that an interval of 7–9 days between doses, if feasible, might be preferred (610–612).”
From Sexually Transmitted Infections Treatment Guidelines, 2021 (2021) · cites this paper as [612]
Citations
Cites
Bulletin of the World Health Organization
van der Sande, M. A. B., Walraven, G. E. L., Milligan, P. J., BANYA, W. A. S., CEESAY, S. M., Nyan, O. A., & McAdam, K. P. W. J. (2001) · Bulletin of the World Health Organization · Cited by 7,097
Bulletin of the World Health Organization
C., N. H. (1955) · British Journal of Sociology · doi:10.2307/587237 · Cited by 3,663
Neurosyphilis and Penicillin Levels in Cerebrospinal Fluid
Mohr, J. A. (1976) · JAMA: The Journal of the American Medical Association · doi:10.1001/jama.1976.03270200046031 · Cited by 178
The British Journal of Venereal Diseases
P., R. J. G. (1926) · Journal of The Royal Naval Medical Service · doi:10.1136/jrnms-12-78a · Cited by 157
Persistence of Treponema pallidum Following Penicillin G Therapy: Report of Two Cases
Tramont, E. C. (1976) · JAMA · doi:10.1001/jama.236.19.2206 · Cited by 146
Penicillin Levels in Blood and CSF Achieved by Treatment of Syphilis
DUNLOP, E. M. C. (1979) · JAMA · doi:10.1001/jama.1979.03290490044025 · Cited by 89
Failure of Penicillin G Benzathine in the Treatment of Neurosyphilis
Greene, B. M. (1980) · Archives of Internal Medicine · doi:10.1001/archinte.1980.00330190129043 · Cited by 78
Benzathine penicillin G in the treatment of syphilis.
Smith, C. A., Kamp, M., Olansky, S., & Price, E. V. (1956) · Europe PMC (PubMed Central) · Cited by 72
Penicillin concentrations in cerebrospinal fluid after different treatment regimens for syphilis.
Polnikorn, N., Witoonpanich, R., Vorachit, M., Vejjajiva, S., & VEJJAJIVA, A. (1980) · Sexually Transmitted Infections · doi:10.1136/sti.56.6.363 · Cited by 72
Production of treponemicidal concentration of penicillin in cerebrospinal fluid.
DUNLOP, E. M. C., Al-Egaily, S. S., & Houang, E. T. (1981) · BMJ · doi:10.1136/bmj.283.6292.646 · Cited by 40
Cited by
Sexually Transmitted Infections Treatment Guidelines, 2021
Workowski, K. A., Bachmann, L. H., Chan, P. A., Johnston, C. M., Muzny, C. A., Park, I., Reno, H., Zenilman, J. M., & Bolan, G. A. (2021) · MMWR. Recommendations and Reports · doi:10.15585/mmwr.rr7004a1 · Cited by 3,018
Sexually Transmitted Diseases Treatment Guidelines, 2010
Workowski, K., & BOLAN, G. A. (2011) · Annals of Emergency Medicine · doi:10.1016/j.annemergmed.2011.04.006 · Cited by 2,074
Syphilis during pregnancy: a preventable threat to maternal-fetal health
Rac, M. W. F., Revell, P. A., & Eppes, C. S. (2016) · American Journal of Obstetrics and Gynecology · doi:10.1016/j.ajog.2016.11.1052 · Cited by 146
Rolfs, R. T. (1995) · Clinical Infectious Diseases · doi:10.1093/clinids/20.supplement_1.s23 · Cited by 68
Goldmeier, D., & Hay, P. (1992) · New England Journal of Medicine · doi:10.1056/nejm199209243271315 · Cited by 44
Congenital Syphilis Prevention: Strategies, Evidence, and Future Directions
Plotzker, R. E., Murphy, R. D., & Stoltey, J. E. (2018) · Sexually Transmitted Diseases · doi:10.1097/olq.0000000000000846 · Cited by 39
A Review and Update on Adult Syphilis, with Particular Reference to its Treatment
Goldmeier, D., & Hay, P. (1993) · International Journal of STD & AIDS · doi:10.1177/095646249300400203 · Cited by 31
Neurosyphilis after treatment of latent syphilis with benzathine penicillin.
Jorgensen, J., Tikjøb, G., & Weismann, K. (1986) · Sexually Transmitted Infections · doi:10.1136/sti.62.2.129 · Cited by 21
On the potential roles of ticks and migrating birds in the ecology of West Nile virus
Hagman, K., Barboutis, C., Ehrenborg, C., Fransson, T., Jaenson, T. G. T., Lindgren, P., Lundkvist, Å., Nyström, F., Waldenström, J., & Salaneck, E. (2014) · Infection Ecology & Epidemiology · doi:10.3402/iee.v4.20943 · Cited by 17
Antibiotics in cutaneous medicine: an update
Carter, E. L. (2003) · Seminars in Cutaneous Medicine and Surgery · doi:10.1016/s1085-5629(03)00046-4 · Cited by 9
Activity of an Antimicrobial Hydrocephalus Shunt Catheter against Propionibacterium acnes
Bayston, R., Vera, L., & Ashraf, W. (2010) · Antimicrobial Agents and Chemotherapy · doi:10.1128/aac.00540-10 · Cited by 8
“acnes is almost always fully susceptible to penicillin, but as with many other antimicrobials, cerebrospinal fluid concentrations of penicillin after a single intravenous injection are too low to be of prophylactic value (15).”
BackgroundLi, Y., Okayama, A., Hagi, T., Muto, C., Raber, S., & Nagashima, M. (2024) · The Journal of Clinical Pharmacology · doi:10.1002/jcph.2454 · Cited by 5
Johnson, K. A., Burghardt, N., Snyder, R. E., Plotzker, R. E., Imp, B. M., Murphy, R., Jacobson, K. R., & Tang, E. C. (2023) · Open Forum Infectious Diseases · doi:10.1093/ofid/ofad300 · Cited by 3
“018 μg/mL [10, 18]) throughout the treatment period for syphilis of late or unknown duration [19].”
BackgroundCurrent management of syphilis infection
Vera, J. H., Parkes, R., & Goldmeier, D. (2009) · International Journal of STD & AIDS · doi:10.1258/ijsa.2009.009233 · Cited by 3
Goldmeier, D., & Skinner, C. J. (1995) · CNS Drugs · doi:10.2165/00023210-199503050-00002 · Cited by 1
Sexuell übertragbare Krankheiten
Orfanos, C. E., & Garbe, C. (2002) · Springer eBooks · doi:10.1007/978-3-642-56219-8_8
Sexuell übertragbare Krankheiten
Orfanos, C. E., & Garbe, C. (1995) · Springer eBooks · doi:10.1007/978-3-642-97602-5_8
Kulkarni, P. A., & Serpa, J. A. (2018) · Springer eBooks · doi:10.1007/978-3-319-92678-0_13
Birru, E. M., Salman, S., Page‐Sharp, M., Baye, C., Manning, L., Moore, B. R., & Batty, K. T. (2026) · Journal of Antimicrobial Chemotherapy · doi:10.1093/jac/dkag145
Metadata
- Authors
- Frentz, G., Nielsen, P. B., Espersen, F., Czartoryski, A., & Aastrup, H.
- Affiliations
- University of Copenhagen (DK)
- Statens Serum Institut (DK)
- ORCID
- Nielsen, P. B.
- Venue
- European Journal of Clinical Microbiology
- Published
- 1984-04
- Volume
- 3
- Issue
- 2
- Pages
- 147-149
- ISSN
- 0934-9723 (ISSN-L)
- 0722-2211
- 1435-4373
- OpenAlex
- W2021286659
- Cited by
- 19
- References
- 13
- Citations by year
- 2026: 1 · 2024: 1 · 2023: 1 · 2021: 1 · 2018: 2 · 2016: 1 · 2014: 1
- FWCI
- 0.43
- Type
- journal article
- Language
- en
- Open access
- closed
- Licence
- www.springer.com/tdm (tdm)
- Locations
- European Journal of Clinical Microbiology & Infectious Diseases (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Pharmacology (medical) › Antibiotics Pharmacokinetics and Efficacy
- Health Sciences › Medicine › Infectious Diseases › Syphilis Diagnosis and Treatment
- Health Sciences › Medicine › Pharmacology (medical) › Historical Medical Research and Treatments
- Keywords
- benzathine penicillin G, intramuscular injection, cerebrospinal fluid, plasma drug concentration, neurosyphilis, penicillin pharmacokinetics, neurological symptoms
- MeSH terms
- Adult, Aged, Female, Humans, Injections, Intramuscular, Male, Middle Aged, Neurosyphilis, Penicillin G Benzathine, Penicillins, Treponema
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
Data sources
Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
