The DOI matches its Crossref record.
Liver injuries induced by herbal medicine, Syo-saiko-to (xiao-chai-hu-tang)
Abstract
Four patients treated with the herbal medicine syo-saiko-to (xiao-chai-hu-tang) exhibited acute drug-induced liver injury. The latent period was one and a half to three months. All of the patients showed a rise in aminotransferases after readministration or challenge test. The liver histology revealed centrilobular confluent necrosis or spotty necrosis, microvesicular fatty change, acidophilic degeneration, and a granuloma. Cholestasis was seen in two patients. The results of the [13C]aminopyrine breath test, performed in one patient, were low before the challenge test and even lower after the challenge. These findings suggest that the herbal medicine syo-saiko-to may induce acute injury or the hepatocellular pattern with variable cholestasis.
Overview
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
Laboratory studies have shown that natural medicines such as Heshouwu, Leigongteng, or Xiao-Chai-Hu-Tang cause immune activation, metabolic disorders, apoptosis and damage to liver cells.
“although laboratory studies have also shown that these treatments cause immune activation, metabolic disorders, apoptosis and damage to liver cells.[35][36][37][38][39]”
From Incidence and Etiology of Drug-Induced Liver Injury in Mainland China (2019) · cites this paper as [35]
Citations
Cites
No references could be resolved yet.
Research works printed but not linked: 20
- Stillman AE, Huxtable R, Consroe P, Kohnen P, Smith S: Hepatic veno-occlusive disease due to pyrrolizidine (senecio) poisoning in Arizona. Gastroenterology 73:349–352, 1977 · DOI
- Hyde FF: Mistletoe hepatitis. Br Med J 282:739, 1981 · DOI
- Rottman JN: Comfrey and liver damage. Lancet 1:944, 1981 · DOI
- Anderson C: Comfrey in perspective. Lancet 1:1424, 1981 · DOI
- Kumana CR, Ng M, Lin HJ, Ko W, Wu P-C, Todd D: Hepatic veno-occlusive disease due to toxic alkaloid in herbal tea. Lancet 1:1360–1361, 1983 · DOI
- Mizoguchi Y, Yoshiyasu K, Tsutsui H, Myyajima K, Sakagami Y, Tojo T, Seki M, Yamamoto Y, Morisawa S: A case of drug-induced allergic hepatitis by herbal medicine. Acta Hepatol Jpn 27:238–241, 1986 · DOI
- Satake I, Maeda M, Koyama W, Sakamoto S, Koizumi S, Kanayama M: A case of hepatic injury caused by an herb drug. Acta Hepatol Jpn 27:238–241, 1986 · DOI
- Harvey J, Colin-Jones DG: Mistletoe hepatitis. Br Med J 282:186–187, 1981 · DOI
- MacGregor FB, Abernethy VE, Dahabra S, Cobden I, Hayes PC: Hepatotoxicity of herbal remedies. Br Med J 199:1156–1157, 1989 · DOI
- Weeks GR, Proper JS: Herbal medicines—gaps in our knowledge. Aust J Hosp Pharmacol 19:155–157, 1989
- Carlsson C: Herbs and hepatitis. Lancet 2:1065, 1990
- Larrey D, Vial T, Pauwels A, Castot A, Biour M, David M, Michel H: Hepatitis after germander (Teucrium chamaedrys) administration: Another instance of herbal medicine hepatotoxicity. Ann Intern Med 117:129–132, 1992 · DOI
- Marutani K, Nishijima T, Nishiyama J, Nemoto H, Matsuo S, Matsuyama Y, Itoh S: Changes in liver test results after stopping syo-saiko-to. Acta Hepatol Jpn 31(suppl):119, 1990
- Marutani K, Matsuo S, Nishijima T, Watanobe T, Ishida Y, Sasaki K, Kameda C, Itoh S: Light and electron microscopic findings in the liver of five patients with syo-saiko-to-induced hepatitis. Jpn J Gastroenterol 87:640, 1990
- Itabashi M: Clinical utility of13C-aminopyrine breath test in patients with chronic liver diseases. J Saitama Med School 18:261–268, 1991
- Hepner GW, Vesell ES: Quantitative assessment of hepatic function by breath analysis after oral administration of [14C]aminopyrine. Ann Intern Med 83:632–638, 1975 · DOI
- Stricker BHCH, Block APR, Desmet VJ: Pathology of Drug-Induced Hepatic Injury, 2nd ed. Amsterdam, Elsevier, 1992, pp 51–70
- Loeper J, Deseatoire V, Letteron P, Moulis C, Degott C, Dansette P, Fau D, Pessayre D: Hepatotoxicity of germander in mice. Gastroenterology 106:464–472, 1994 · DOI
- Keys JD: Chinese Herbs. Their Botany, Chemistry, and Pharmacodynamics. Rutland, Vermont, Charles E. Tuttle, 1976
- De Smet PAGM:Scutellaria species.In Adverse Effects of Herbal Drugs, Vol 2. PAGM De Smet, K Keller, R Hänsel (eds). Berlin, Springer-Verlag, 1993, pp 289–296 · DOI
Cited by
Sorted by citations
Incidence and Etiology of Drug-Induced Liver Injury in Mainland China
Shen, T., Liu, Y., Shang, J., Xie, Q., Li, J., Yan, M., Xu, J., Niu, J., Liu, J., Watkins, P. B., et al. (2019) · Gastroenterology · doi:10.1053/j.gastro.2019.02.002 · Cited by 615
Metadata
- Authors
- Itoh, S., Marutani, K., Nishijima, T., Matsuo, S., & Itabashi, M.
- Venue
- Digestive Diseases and Sciences
- Published
- 1995-08
- Volume
- 40
- Issue
- 8
- Pages
- 1845-1848
- ISSN
- 0163-2116
- 1573-2568
- Cited by
- 100
- References
- 0
- Language
- en
- Licence
- www.springer.com/tdm (tdm)
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
