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Immunochemical quantification of human plasma Lp(a) lipoprotein
Abstract
The Lp(a) lipoprotein was purified from human plasma by ultracentrifugation and gel filtration on 6% agarose. It contained 27% protein, 65% lipid, and 8% carbohydrate. Quantification of the Lp(a) lipoprotein was performed by radial immunodiffusion. Both within‐assay and between‐assay coefficients of variation were inversely concentration dependent, decreasing from 20% and 27%, respectively, at 3 mg/100 ml to 7% and 12%, respectively, at concentrations above 8 mg/100 ml. The lower limit of sensitivity of the assay was 1.5 mg/100 ml. Of 340 unrelated fasting subjects tested, 81% had levels of the Lp(a) lipoprotein exceeding this lower limit. The distribution of Lp(a) concentrations in this population was skewed with a mean of 14 mg/100 ml and a median of 8 mg/100 ml. Lp(a) lipoprotein was not significantly correlated with age, sex, or cholesterol or glyceride concentrations.
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Citations
Cited by
Warnick, G. R., & Albers, J. J. (1978) · Journal of Lipid Research · doi:10.1016/s0022-2275(20)41577-9 · Cited by 1,250
Self-citationBoerwinkle, E., Leffert, C. C., Lin, J., Lackner, C., Chiesa, G., & Hobbs, H. H. (1992) · Journal of Clinical Investigation · doi:10.1172/jci115855 · Cited by 962
Reyes-Soffer, G., Ginsberg, H. N., Berglund, L., Duell, P. B., Heffron, S. P., Kamstrup, P. R., Lloyd-Jones, D. M., Marcovina, S. M., Yeang, C., Koschinsky, M. L., et al. (2022) · Arteriosclerosis, Thrombosis, and Vascular Biology · doi:10.1161/atv.0000000000000147 · Cited by 836
Bostom, A. G. (1996) · JAMA · doi:10.1001/jama.1996.03540070040028 · Cited by 398
The Measurement of Apolipoprotein A-I and A-II Levels in Men and Women by Immunoassay
Cheung, M. C., & Albers, J. J. (1977) · Journal of Clinical Investigation · doi:10.1172/jci108767 · Cited by 381
Self-citationMarcovina, S. M., Albers, J. J., Gabel, B., Koschinsky, M. L., & Gaur, V. P. (1995) · Clinical Chemistry · doi:10.1093/clinchem/41.2.246 · Cited by 354
Self-citationQuantitation of apolipoprotein A-I of human plasma high density lipoprotein
Albers, J. J., Wahl, P. W., Cabana, V. G., Hazzard, W. R., & Hoover, J. J. (1976) · Metabolism · doi:10.1016/0026-0495(76)90060-3 · Cited by 342
Self-citationLipoprotein (a) measurements for clinical application
Marcovina, S. M., & Albers, J. J. (2016) · Journal of Lipid Research · doi:10.1194/jlr.r061648 · Cited by 338
Self-citationLipoprotein(a) as a strong indicator for cerebrovascular disease.
Zenker, G., Költringer, P., Boné, G., Niederkorn, K., Pfeiffer, K., & Jürgens, G. (1986) · Stroke · doi:10.1161/01.str.17.5.942 · Cited by 329
Marcovina, S. M., Albers, J. J., Scanu, A. M., Kennedy, H., Giaculli, F., Berg, K., Couderc, R., Dati, F., Rifai, N., Sakurabayashi, I., et al. (2000) · Clinical Chemistry · doi:10.1093/clinchem/46.12.1956 · Cited by 313
Self-citationBoerwinkle, E., Menzel, H. J., Kraft, H. G., & Utermann, G. (1989) · Human Genetics · doi:10.1007/bf00288277 · Cited by 262
Protein composition of Lp(a) lipoprotein from human plasma
Utermann, G., & Weber, W. (1983) · FEBS Letters · doi:10.1016/0014-5793(83)80182-3 · Cited by 255
Uptake of Lp(a) lipoprotein by cultured fibroblasts
Floren, C.-H., Albers, J. J., & Bierman, E. L. (1981) · Biochemical and Biophysical Research Communications · doi:10.1016/s0006-291x(81)80179-9 · Cited by 67
Self-citation
Metadata
- Authors
- Albers, J. J., & Hazzard, W. R.
- Venue
- Lipids
- Publisher
- Wiley
- Published
- 1974-01
- Volume
- 9
- Issue
- 1
- Pages
- 15-26
- ISSN
- 0024-4201 (ISSN-L)
- 1558-9307
- OpenAlex
- W1976485306
- Cited by
- 217
- References
- 0
- FWCI
- 20.80
- Type
- journal article
- Language
- en
- Open access
- closed
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