Mechanisms of free radical oxidation of unsaturated lipids
Abstract
The primary products formed from the autoxidation of lipids can be understood based upon a mechanism that involves five different reaction types. These reactions are: reaction of a carbon radical and molecular oxygen, atom transfer of a hydrogen from substrate to the chain carrying peroxyl, fragmentation of the chain carrying peroxyl to give oxygen and a carbon radical, rearrangement of the peroxyl, and cyclization of the peroxyl. The mechanism of these primary reaction steps has been the focus of extensive research over the past fifty years, and the current level of understanding of these transformations is the subject of this review.
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The abundant diffusible products of lipid peroxidation are chemically reactive aldehydes including malondialdehyde (MDA), acrolein, 4-hydroxy-2-hexenal (4-HHE), and 4-hydroxy-2-nonenal (4-HNE).
“The abundant diffusible products of lipid peroxidation are chemically reactive aldehydes including malondialdehyde (MDA), acrolein, 4-hydroxy-2-hexenal (4-HHE), and 4-hydroxy-2-nonenal (4-HNE) [57,58].”
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References 103 · Cited by 1,208
- Authors
- Porter, N. A., Caldwell, S. E., & Mills, K. A.
- Affiliations
- Duke University (US)
- ORCID
- Porter, Ned A.
- Venue
- Lipids
- Publisher
- Wiley
- Published
- 1995-04
- Volume
- 30
- Issue
- 4
- Pages
- 277-290
- ISSN
- 0024-4201 (ISSN-L)
- 1558-9307
- OpenAlex
- W2057129789
- Cited by
- 1,208
- References
- 103
- Citations by year
- 2026: 27 · 2025: 35 · 2024: 39 · 2023: 30 · 2022: 27 · 2021: 34 · 2020: 42 · 2019: 41 · 2018: 48 · 2017: 39 · 2016: 43 · 2015: 61 · 2014: 49 · 2013: 42 · 2012: 56
- FWCI
- 4.36
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Lipids (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Physical Sciences › Chemistry › Organic Chemistry › Free Radicals and Antioxidants
- Health Sciences › Medicine › Biochemistry › Antioxidant Activity and Oxidative Stress
- Physical Sciences › Chemistry › Organic Chemistry › Edible Oils Quality and Analysis
- Keywords
- lipid autoxidation, free radical oxidation, unsaturated lipids, peroxy radicals, carbon-centered radicals, hydrogen atom transfer
- MeSH terms
- Free Radicals, Oxidation-Reduction, Peroxides, Polyenes, Stereoisomerism, Lipid Peroxidation, Molecular Structure
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