Liver regeneration following portacaval shunt in rats: 3′, 5′-cyclic AMP changes in plasma and liver tissue
Abstract
Hepatic regeneration following portacaval shunt was evaluated in the light of the changes of 3',5'-cyclic AMP (cAMP) levels in plasma and liver tissue, and also plasma cAMP levels after glucagon administration, using a 70% hepatectomy and portacaval shunt model in rats. Ratios of liver to body weight recovered to 60% of pre-operative ratios 2 weeks after the operation. Plasma cAMP level decreased slightly, but insignificantly, 1 day and 3 days after the operation, then recovered to the pre-operative level. Hepatic cAMP concentration increased for 2 weeks after the operation. Plasma cAMP levels induced after glucagon administration did not increase until 3 days after the operation and were only 50% of pre-operative levels 4 weeks after the operation. From these results, liver regeneration following the portacaval shunt was remarkably delayed, but continued until at least 2 weeks after the operation.
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Liver regeneration slows down if hepatectomy is performed after portocaval shunting.
“Additionally, studies have shown that LR slows down if hepatectomy is performed after portocaval shunting[38,39].”
From Liver regeneration after partial hepatectomy: Triggers and mechanisms (2025) · cites this paper as [38]
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Liver regeneration after partial hepatectomy: Triggers and mechanisms
Korchilava, B., Khachidze, T., Megrelishvili, N., Svanadze, L., Kakabadze, M., Tsomaia, K., Jintcharadze, M., & Kordzaia, D. (2025) · World Journal of Hepatology · doi:10.4254/wjh.v17.i7.107378 · Cited by 21 · see citing works
- Authors
- Hata, Y., Yoshikawa, Y., Une, Y., Sasaki, F., Nakajima, Y., Takahashi, H., Namieno, T., & Uchino, J.
- Affiliations
- Hokkaido University (JP)
- Venue
- Research in Experimental Medicine
- Published
- 1992-12
- Volume
- 192
- Issue
- 1
- Pages
- 131-136
- ISSN
- 0300-9130 (ISSN-L)
- 1433-8580
- OpenAlex
- W2029082233
- Cited by
- 4
- References
- 0
- Citations by year
- 2025: 1
- FWCI
- 0.23
- Type
- journal article
- Language
- en
- Open access
- closed
- Licence
- www.springer.com/tdm (tdm)
- Locations
- Research in Experimental Medicine (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Hepatology › Liver physiology and pathology
- Health Sciences › Medicine › Surgery › Organ Transplantation Techniques and Outcomes
- Health Sciences › Medicine › Hepatology › Liver Disease and Transplantation
- Keywords
- liver regeneration, portacaval shunt, cyclic AMP, plasma cAMP, glucagon, hepatectomy, portal hypertension
- MeSH terms
- Cyclic AMP, Animals, Liver, Liver Regeneration, Male, Portacaval Shunt, Surgical, Rats, Inbred Strains, Rats
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