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Cited by 103

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Antioxidative constituents fromlycopus lucidus

Woo, Eun-Rhan, Piao, Mei Shan·2004·Archives of Pharmacal Research
DOI 10.1007/bf02980102
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Abstract

Three phenolic compounds, rosmarinic acid (1), methyl rosmarinate (2), ethyl rosmarinate (3), and two flavonoids, luteolin (4), luteolin-7-O-beta-D-glucuronide methyl ester (5) were isolated from the aerial part of Lycopus lucidus (Labiatae). Their structures were determined by chemical and spectral analysis. Compounds 1-5 exhibited potent antioxidative activity on the NBT superoxide scavenging assay. The IC50 values for compounds 1-5 were 2.59, 1.42, 0.78, 2.83, and 3.05 microg/mL respectively. In addition, five compounds were isolated from this plant for the first time.

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Research works printed but not linked: 13

  1. Akdemir, Z. Ş., Tati, II., Saraccoglu, I., ismailoğlu, U. B., SahinErdemli, I., and Caliş, I., Polyphenolic compounds fromGeranium pratense and their free radical scavenging activities.Phytochemistry, 56, 189–193 (2001). · DOI
  2. Dapkevicius, A., Beek, T. A., Lelyveld, G. P., Veldhuizen, A., Groot, A., Linssen, J. P. H., and Venskutonis, R., Isolation and structure elucidation of radical scavengers fromThymus vulgaris leaves.J. Nat. Prod., 65, 892–896 (2002). · DOI
  3. Do, J. C., Chai, J. Y., and Son, J. K., Studies on the constituents ofLycopus lucidus (I).Kor. J. Pharmacogn., 22, 162–165 (1991a).
  4. Do, J. C., Chai, J. Y., and Son, J. K., Studies on the constituents ofLycopus lucidus (II).Kor. J. Pharmacogn., 22, 166–170 (1991b).
  5. Hou, Z.-F., Tu, Y.-Q., and Li, Y., Three new phenolic compounds fromNepeta prattii.J. Chin. Chem. Soc., 49, 255–258 (2002). · DOI
  6. Kirby, A. J. and Schmidt, R. J., The antioxidant activity of Chinese herbs for eczema and of placebo herbs - I.J. Ethnopharmacol., 56, 103–108 (1997). · DOI
  7. Kuo, Y.-H., Lee, S.-M., and Lai, J.-S., Constituents of the whole herb ofClinoponium laxiflorum.J. Chin. Chem. Soc., 47, 241–246 (2000). · DOI
  8. Lee, M. H., Son, Y. K., and Han, Y. N., Tissue factor inhibitory flavonoids from the fruits ofChaenomeles sinensis.Arch. Pharm. Res., 25, 842–850 (2002). · DOI
  9. Matsuda, H., Cai, H., Kubo, M., Tosa, H., and Inuma, M., Study on anti-cataract drugs from natural sources. II. Effects on Buddlejae Flos onin vitro aldose reductase activity.Biol. Pharm. Bull., 18, 462–466 (1995).
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  12. Schulz, M., Strack, D., Weissenbock, G., Markham, K. R., Dellamonica, G., and Chopin, J., Two luteolin O-glucuronides from primary leaves ofSecale cereale.Phytochemistry, 24, 343–345 (1985). · DOI
  13. Wang, Y., Ohtani, K., Kasai, R., and Yamasaki, K., Flavonol glycosides and phenolics from leaves ofCordia dichotoma.Nat. Med., 50, 367–367 (1996).

Cited by

Metadata

Authors
Woo, E.-R., & Piao, M. S.
Venue
Archives of Pharmacal Research
Publisher
Springer Science and Business Media LLC
Published
2004-02
Volume
27
Issue
2
Pages
173-176
ISSN
  • 0253-6269
  • 1976-3786
DOI
10.1007/bf02980102
Cited by
103
References
0
Language
en
Licence
www.springer.com/tdm (tdm)

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