Cited by 1,450Evolution and Genetic DynamicsProbability and Statistical ResearchBacterial Genetics and Biotechnology

The distribution of the numbers of mutants in bacterial populations

Lea, D. E., Coulson, C. A.·1949·Journal of Genetics

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Crossref · 10.1007/bf02986080

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  • The first mutant distribution is due to Lea and Coulson (1949).

    “The first mutant distribution is due to Lea and Coulson (1949).”

    From rSalvador: An R Package for the Fluctuation Experiment (2017) · cites this paper as Lea and Coulson 1949

  • In most published applications of the fluctuation experiment, inference about m relied on the Lea-Coulson mutant distribution.

    “In most published applications of the fluctuation experiment, inference about m relied on the Lea-Coulson mutant distribution (Lea and Coulson 1949) defined by the PGF G1∗(z;m) given in Equation (3).”

    From rSalvador: An R Package for the Fluctuation Experiment (2017) · cites this paper as Lea and Coulson 1949

  • The Lea-Coulson method of the median (LC) is the classic model for the estimation of mutation rates.

    “While the Lea-Coulson method of the median (LC), introduced in 1949 (Lea and Coulson, 1949), is the classic model for the estimation of mutation rates, statistical analyses have evolved to more accurately estimate m.”

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References 7 · Cited by 1,450

Authors
Lea, D. E., & Coulson, C. A.
Affiliations
  • University of Cambridge (GB)
  • King's College London (GB)
Venue
Journal of Genetics
Published
1949-12
Volume
49
Issue
3
Pages
264-285
ISSN
0022-1333 (ISSN-L)
OpenAlex
W2013735712
Cited by
1,450
References
7
Citations by year
2026: 12 · 2025: 17 · 2024: 22 · 2023: 30 · 2022: 11 · 2021: 21 · 2020: 25 · 2019: 28 · 2018: 23 · 2017: 29 · 2016: 29 · 2015: 28 · 2014: 25 · 2013: 39 · 2012: 29
FWCI
8.61
Type
journal article
Language
en
Open access
closed
Locations
  • Journal of Genetics (publishedVersion)
  • PubMed (publishedVersion)
Topics
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Evolution and Genetic Dynamics
  • Physical Sciences › Mathematics › Statistics and Probability › Probability and Statistical Research
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Bacterial Genetics and Biotechnology
Keywords
bacterial populations, mutation rate, probability tables
MeSH terms
Genetics, Humans

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