All-trans retinoic acid-associated low molecular weight water-soluble chitosan nanoparticles based on ion complex
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Formulations with high (above 100 μg/mg), medium (between 100 and 25 μg/mg), and low (below 25 μg/mg) RA loading have been described.
“Formulations with high (above 100 μg/mg of formulation)51,56,60, medium (between 100 and 25 μg/mg of formulation)44,45, and low (below 25 μg/mg of formulation)7,58 loading have been described.”
From Advances and challenges in retinoid delivery systems in regenerative and therapeutic medicine (2020) · cites this paper as [51]
Because of the hydrophobicity of RA, the occurrence of a burst release in most formulations is negligible.
“Because of the hydrophobicity of RA, the occurrence of a burst release in most formulations is negligible44,47,51,63.”
From Advances and challenges in retinoid delivery systems in regenerative and therapeutic medicine (2020) · cites this paper as [51]
In physical interaction, RA is complexed with positively charged polymers such as chitosan or PEI; the carboxylic acid of RA interacts electrostatically with the amine group located in the polymer, forming a complex that can be stabilized by addition of a polyanion and divalent ions.
“Regarding physical interaction, RA is complexed with positively charged polymers such as chitosan, or PEI43,51. The carboxylic acid of RA interacts electrostatically with the amine group located in the polymer, forming a complex that can be stabilized by addition of a polyanion and divalent ions43,44.”
From Advances and challenges in retinoid delivery systems in regenerative and therapeutic medicine (2020) · cites this paper as [51]
In general, formulations with high RA loading show a slower release profile of the drug.
“In general, formulations with high RA loading show a slower release profile of the drug51.”
From Advances and challenges in retinoid delivery systems in regenerative and therapeutic medicine (2020) · cites this paper as [51]
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References 28 · Cited by 33
- Authors
- Kim, D.-G., Choi, C., Jeong, Y.-I., Jang, M.-K., Nah, J.-W., Kang, S.-K., & Bang, M.-S.
- Affiliations
- Sunchon National University (KR)
- Kongju National University (KR)
- Corresponding author
- Nah, Jae-Woon
- Venue
- Macromolecular Research
- Published
- 2006-02
- Volume
- 14
- Issue
- 1
- Pages
- 66-72
- ISSN
- 1225-5947 (ISSN-L)
- 1598-5032
- 2092-7673
- OpenAlex
- W2158048265
- Cited by
- 33
- References
- 28
- Citations by year
- 2026: 1 · 2024: 2 · 2020: 2 · 2018: 1 · 2017: 2 · 2015: 1 · 2014: 2 · 2013: 4 · 2012: 2
- FWCI
- 2.21
- Type
- journal article
- Language
- en
- Open access
- closed
- Licence
- www.springer.com/tdm (tdm)
- Locations
- Macromolecular Research (publishedVersion)
- Topics
- Life Sciences › Pharmacology, Toxicology and Pharmaceutics › Pharmaceutical Science › Advanced Drug Delivery Systems
- Physical Sciences › Materials Science › Biomaterials › Nanoparticle-Based Drug Delivery
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Medicine › Hydrogels: synthesis, properties, applications
- Keywords
- all-trans retinoic acid, low molecular weight chitosan, chitosan nanoparticles, polyion complex, drug encapsulation, controlled drug release, cytotoxicity, drug delivery
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