A randomized controlled study on effects of ibuprofen on cognitive progression of Alzheimer’s disease
Pasqualetti, Patrizio, Bonomini, Cristina, Dal Forno, Gloria, Paulon, Luca, Sinforiani, Elena, Marra, Camillo, Zanetti, Orazio, Maria Rossini, Paolo·2009·Aging Clinical and Experimental Research
Cited by (172)
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- Microglia as a cellular target of diclofenac therapy in Alzheimer’s diseaseStopschinski, Barbara E., Weideman, Rick A., McMahan, Danni, Jacob, David A., Little, Bertis B., Chiang, Hsueh-Sheng, Saez Calveras, Nil, Stuve, Olaf · 2023 · Therapeutic Advances in Neurological Disorders
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- Peripheral inflammation and neurodegeneration; a potential for therapeutic intervention in Alzheimer’s disease (AD), Parkinson’s disease (PD) and amyotrophic lateral sclerosis (ALS)Lourdes Hanna, Edward Poluyi, Chibuikem Anthony Ikwuegbuenyi, Eghosa Morgan, Grace Imaguezegie · 2022 · The Egyptian Journal of Neurosurgery : the official publication of the Egyptian Society of Neurological Surgeons/Egyptian journal of neurosurgery
- Independent
<scp>
<i>APOE4</i>
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knock‐in mouse models display reduced brain
<scp>APOE</scp>
protein, altered neuroinflammation, and simplification of dendritic spinesSepulveda, Jordy, Luo, Nancy, Nelson, Matthew, Ng, Christi Anne S., Rebeck, George William · 2022 · Journal of Neurochemistry
- Patterns of anti‐inflammatory drug use and risk of dementia: a matched case–control studyAlex Dregan, Phil Chowienczyk, David Armstrong · 2015 · European Journal of Neurology
- Is it All Said for NSAIDs in Alzheimer’s Disease? Role of Mitochondrial Calcium UptakeSara Sanz‐Blasco, María Calvo-Rodríguez, Erica Caballero, Mónica García-Durillo, Lucı́a Núñez, Carlos Villalobos · 2017 · Current Alzheimer Research
- An overview of investigational antiapoptotic drugs with potential application for the treatment of neurodegenerative disordersAntoni Camins, Francesc Xavier Sureda, Fèlix Junyent, Ester Verdaguer, Jaume Folch, Carlos Beas‐Zárate, Mercè Pallàs · 2010 · Expert Opinion on Investigational Drugs
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- Mechanisms of comorbidity between Alzheimer's disease and painKaifang Yao, Shenjun Wang, Zhifang Xu, Zezhi Fan, Zhihan Chen, Peng Jia, Shiwei Tu, Yangyang Liu, Xiaowei Lin, Yuan Xu et al. · 2025 · Alzheimer s & Dementia
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- Long‐Term Exposure to Non‐Steroidal Anti‐Inflammatory Medication in Relation to Dementia RiskIlse vom Hofe, Bruno H. Ch. Stricker, Muhammad Aimen Ikram, Frank J. Wolters, M. Arfan Ikram · 2025 · Journal of the American Geriatrics Society
- A tough trek in the development of an anti-amyloid therapy for Alzheimer's disease: Do we see hope in the distance?Jin Jun Luo, William Wallace, John W. Kusiak · 2022 · Journal of the Neurological Sciences
- Determining the Molecular Pathways Underlying the Protective Effect of Non-Steroidal Anti-Inflammatory Drugs for Alzheimer's Disease: A Bioinformatics ApproachAlejo J. Nevado‐Holgado, Simon Lovestone · 2016 · Computational and Structural Biotechnology Journal
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- Combination Therapy for the Treatment of Alzheimer’s Disease: Recent Progress and Future ProspectsEkta Shirbhate, Vijay K. Patel, Priya Tiwari, Rakesh Kore, Ravichandran Veerasamy, Achal Mishra, Harish Rajak · 2022 · Current Topics in Medicinal Chemistry
- Modulation of Aβ42 in vivo by γ-secretase modulator in primates and humansI‐Fang Ling, Todd Eliot Golde, Douglas R Galasko, Edward H. Koo · 2015 · Alzheimer s Research & Therapy
- Failure, Success, and Future Direction of Alzheimer Drugs Targeting Amyloid‐β Cascade: Pros and Cons of Chemical and Biological ModalitiesJimin Kim, Hanna Jeon, Hye Yun Kim, Young Soo Kim · 2023 · ChemBioChem
- Ibuprofen and lipoic acid codrug 1 control Alzheimer's disease progression by down-regulating protein kinase C ε-mediated metalloproteinase 2 and 9 levels in β-amyloid infused Alzheimer's disease rat model.S. Zara, M. Rapino, P. Sozio, A. Di Stefano, Cinzia Nasuti, A. Cataldi · 2011 · Brain Research
- Recent Studies on Design and Development of Drugs Against Alzheimer’s Disease (AD) Based on Inhibition of BACE-1 and Other AD-causative AgentsSatya P. Gupta, Vaishali Manikrao Patil · 2020 · Current Topics in Medicinal Chemistry
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- Immune modulations and immunotherapies for Alzheimer’s disease: a comprehensive reviewSara Mahdiabadi, Sara Momtazmanesh, George L. Perry, Nima Rezaei · 2021 · Reviews in the Neurosciences
- Exploring nanoparticular platform in delivery of repurposed drug for Alzheimer’s disease: current approaches and future perspectivesSnigdha Chakraborty, Sukriti Vishwas, Vancha Harish, Gaurav Gupta, Keshav Raj Paudel, Muralikrishnan Dhanasekaran, Bey Hing Goh, Flavia C. M. Zacconi, Terezinha de Jesus Andreoli Pinto, Popat Kumbhar et al. · 2024 · Expert Opinion on Drug Delivery
- Amyloid-modifying therapies for Alzheimer’s disease: therapeutic progress and its implicationsMeaghan C. Creed, Norton William Milgram · 2010 · AGE
- Review Article Neuroinflammation in Alzheimer's disease: Current evidence and future directionsValeria Calsolaro, Paul Edison · 2016
- Dementia.Rob Butler, Raghavakurup Radhakrishnan · 2012 · PubMed Central
- Role of Nonsteroidal Anti-Inflammatory Drugs as a Protective Factor in Alzheimer’s Disease: A Systematic Review and Meta-AnalysisAkash Asthana, Shashank Tripathi, Rachna Agarwal · 2024 · Neurology India
- Role of astroglia and microglia in Alzheimer's disease and multiple therapeutic interventionsLei Li, Ying Wang, Qilin Feng, Chaoyang Ma, Cheng He, Wenjun Wan, Lei Tang · 2025 · Journal of Alzheimer s Disease
- Apolipoprotein E4 in Alzheimer’s Disease: Role in Pathology, Lipid Metabolism, and Drug TreatmentNour F. Al-Ghraiybah, Amer E. Alkhalifa, Yutaka Itokazu, Taylor Farr, Naima Pérez, Hande Ali, Amal Kaddoumi · 2026 · International Journal of Molecular Sciences
- Multi-Target-Directed Ligand Approach in Anti-Alzheimer’s Drug DiscoveryVaishali Manikrao Patil, Neeraj Masand, Vertika Gautam, Shikha Kaushik, Dee H. Wu · 2023 · Springer eBooks
- Combination Drug Therapy for the Treatment of Alzheimer’s DiseaseX. Anton Alvarez, Carlos Linares, Eliezer Masliah · 2012 · European Neurological Review
- Unraveling APOE4: The dual role in CNS and peripheral inflammation in Alzheimer's diseaseXiaohan Li, Zekun Li, Hua Chen, Hongmin Guo, Yihao Ge, Fang Dong, Fan Zhang, Feng Zhang · 2025 · International Immunopharmacology
- A Systematic Review and Meta-Analysis of Randomized Control Trials to Check Role of Non-Steroidal Anti-inflammatory Drugs as Protective Factor in Alzheimer Disease SubjectsAkash Asthana, Shashank Tripathi, Rachna Agarwal · 2023 · Advances in Alzheimer s Disease
- Diabetes and cognitive dysfunctionBhumsoo Kim, Catrina Sims‐Robinson, Stacey A. Sakowski, Eva L. Feldman · 2022 · Elsevier eBooks
- Therapeutic Strategies in Neurodegenerative DiseasesKristi M. Anderson, Rodney Lee Mosley · 2016 · Springer eBooks
- Microwave-assisted synthesis and in vitro stability of N-benzylamide non-steroidal anti-inflammatory drug conjugates for CNS deliveryBrandon D. Eden, Andrew J. Rice, Troy D. Lovett, Olivia M. Toner, Evan P Geissler, William E. Bowman, Sherri C. Young · 2019 · Bioorganic & Medicinal Chemistry Letters
- Molecular Imaging of Neuroinflammation in Alzheimer’s Disease and Mild Cognitive ImpairmentJunhyung Kim, Yong‐Ku Kim · 2023 · Advances in experimental medicine and biology
- Are Inflammatory Profiles the Key to Personalized Alzheimer's treatment?Holly M. Brothers, Donna M. Wilcock · 2013 · Neurodegenerative Disease Management
- REVIEW ON EVALUATING THE ROLE OF NSAIDS FOR THE TREATMENT OF ALZHEIMER'S DISEASEPrayaga Rajappan Krishnendu, B. Arjun, K. VIBINA, NIVEA CLEO T. S., N. K. DRISYA, RADHIKA MOHANDAS, Subin Mary Zachariah, Subin Mary Zachariah · 2021 · International Journal of Applied Pharmaceutics
- Influence of Ibuprofen on glycerophospholipids and sphingolipids in context of Alzheimer´s DiseaseJuliane Radermacher, Vincent Konrad Johannes Erhardt, Oliver Walzer, Elodie Christiane Haas, Konstantin Nicolas Kuppler, Jill Sven René Zügner, Anna Andrea Lauer, Tobias Hartmann, Heike S. Grimm, Marcus O.W. Grimm · 2025 · Biomedicine & Pharmacotherapy
- Possible Role of Amyloidogenic Evolvability in Dementia with Lewy Bodies: Insights from Transgenic Mice Expressing P123H β-SynucleinMasayo Fujita, Gilbert J. Ho, Yoshiki Takamatsu, Ryoko Wada, Kazutaka Ikeda, Makoto Hashimoto · 2020 · International Journal of Molecular Sciences
- Translatability of Animal Models for Alzheimer's Disease Using a Machine Learning Based WorkflowAlex Foster‐Powell, Guy M. L. Meno‐Tetang, Amin Rostami‐Hodjegan, Kayode Ogungbenro, Donald E. Mager · 2025 · Clinical and Translational Science
- Ibuprofen-Glutathione Conjugate as Anti-inflammatory and Anti-apoptotic Agent in Rat Brain Infused with β Amyloid (1-40)De Colli M Sozio P · 2012 · Journal of Cytology & Histology
- Alzheimer’s Disease: An Insightful Review on the Future Trends of the Effective TherapeuticsAfreen Hashmi, Vivek Srivastava, Syed Abul Kalam, Devesh Kumar Mishra · 2022 · IntechOpen eBooks
- Stress oxydant et maladie d’AlzheimerThomas Gilbert, Jocelyne Drai, Marc Bonnefoy · 2013 · Springer eBooks
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- Pijn bij dementie: van experiment tot betere zorgWilco P. Achterberg, Leids Universitair, Erik Scherder · 2010
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- Anti-inflammatory therapy and cerebrospinal fluid diagnosis in Alzheimer's disease.Daniëlle de Jong · 2010 · Radboud Repository (Radboud University)
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- Étude des perturbations astrocytaires sous l’influence de l’apolipoprotéine E4 : implications et applications dans la maladie d’AlzheimerLaurie Arnaud · 2021 · theses.fr (ABES)