Thyrotropin-releasing hormone increases plasma atrial natriuretic peptide levels in human
Abstract
The effect of thyrotropin-releasing hormone (TRH) on plasma atrial natriuretic peptide (ANP), TSH, prolactin, cortisol and aldosterone levels in 26 patients with normal pituitary and thyroid gland function was examined. Bolus iv injection of 200 micrograms TRH produced, between 0 and 60 min, a significant gradual rise of plasma ANP concentrations from 30.4 +/- 2.3 to 54.8 +/- 6.4 pg/ml (mean +/- SE). Plasma prolactin and TSH concentrations increased four- and six-fold of basal values with peak responses at 15 and 30 min, respectively, whereas plasma cortisol and aldosterone concentrations remained unchanged after the drug treatment. The patients had no significant changes in blood pressure or pulse rate. We conclude that there may be indirect mechanism(s) which result in increased ANP levels after TRH administration.
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Thyroid hormone can increase angiotensinogen and atrial natriuretic peptide levels and decrease vasopressin levels.
“thyroid hormone can increase angiotensinogen (16) and atrial natriuretic peptide levels (17,18) and respectively decrease vasopressin levels (19,20).”
From The Role of Thyroid Hormone in Blood Pressure Homeostasis: Evidence from Short-Term Hypothyroidism in Humans (2002) · cites this paper as [18]
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References 24 · Cited by 6
- Authors
- Sergev, O., Rácz, K., Varga, I., Kiss, R., Fütö, L., Mohari, K., & Gláz, E.
- Affiliations
- Semmelweis University (HU)
- Venue
- Journal of Endocrinological Investigation
- Published
- 1990-09
- Volume
- 13
- Issue
- 8
- Pages
- 649-652
- ISSN
- 0391-4097 (ISSN-L)
- 1720-8386
- OpenAlex
- W2041259721
- Cited by
- 6
- References
- 24
- Citations by year
- 2019: 1
- FWCI
- 0.54
- Type
- journal article
- Language
- en
- Open access
- closed
- Licence
- www.springer.com/tdm (tdm)
- Locations
- Journal of Endocrinological Investigation (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Surgery › Cardiovascular, Neuropeptides, and Oxidative Stress Research
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuropeptides and Animal Physiology
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Thyroid Disorders and Treatments
- Keywords
- thyrotropin-releasing hormone, atrial natriuretic peptide, plasma ANP levels, thyroid-stimulating hormone, prolactin, cortisol, aldosterone, pituitary function, thyroid function
- MeSH terms
- Adult, Aldosterone, Female, Humans, Hydrocortisone, Male, Atrial Natriuretic Factor, Prolactin, Radioimmunoassay, Thyrotropin, Thyrotropin-Releasing Hormone
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