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Cited by 277

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UBX domain proteins: major regulators of the AAA ATPase Cdc48/p97

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Schuberth, C., Buchberger, A.·2008·Cellular and Molecular Life Sciences

Abstract

The highly conserved AAA ATPase Cdc48/p97 acts on ubiquitylated substrate proteins in cellular processes as diverse as the fusion of homotypic membranes and the degradation of misfolded proteins. The 'Ubiquitin regulatory X' (UBX) domain-containing proteins constitute the so far largest family of Cdc48/p97 cofactors. UBX proteins are involved in substrate recruitment to Cdc48/p97 and in the temporal and spatial regulation of its activity. In combination with UBX-like proteins and other cofactors, they can assemble into a large variety of Cdc48/p97-cofactor complexes possessing distinct cellular functions. This review gives an overview of the different subfamilies of UBX proteins and their functions, and discusses general principles of Cdc48/p97 regulation by these cofactors.

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Metadata

Authors
Schuberth, C., & Buchberger, A.
Venue
Cellular and Molecular Life Sciences
Published
2008-04-26
Volume
65
Issue
15
Pages
2360-2371
ISSN
  • 1420-682X (ISSN-L)
  • 1420-9071
OpenAlex
W2011325147
Cited by
277
References
3
FWCI
9.31
Type
journal article
Language
en
Open access
hybrid

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