Endogenous retroviruses: Endogenous retroviruses and cancer
Open accessAbstract
The genomes of vertebrates contain sequences that are similar to present-day exogenous retroviruses. Such sequences, called endogenous retroviruses (ERVs), have resulted from ancestral germ line infections by exogenous retroviruses which have thereafter been transmitted in a Mendelian fashion. By analogy to exogenous tumorigenic retroviruses, ERVs have been implicated in the pathogenesis of cancer. Cumulative evidence from animal models indicates that ERVs may participate in the process of malignant transformation or promote tumor growth, e.g. through insertional mutagenesis or via counteracting tumor immunosurveillance. Here, we review the role of ERVs in tumorigenesis with focus on human ERVs (HERVs) in human cancer. Although available data suggest a potential role of HERVs in human cancers, in particular germ cell tumors, the contributions of HERVs to human tumorigenesis warrant further elucidation. (Part of a multi-author review).
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HERV-K(HML2) Rec provides a paradigm of potentially tumor-promoting effects of other HERV proteins.
“and provides a paradigm of potentially tumor-promoting effects of other HERV proteins 12,65.”
From Are human endogenous retroviruses pathogenic? An approach to testing the hypothesis (2013) · cites this paper as [65]
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Subramanian, R. P., Wildschutte, J. H., Russo, C., & Coffin, J. M. (2011) · Retrovirology · doi:10.1186/1742-4690-8-90 · Cited by 439 · see citing works
Studies of endogenous retroviruses reveal a continuing evolutionary saga
Stoye, J. P. (2012) · Nature Reviews Microbiology · doi:10.1038/nrmicro2783 · Cited by 350 · see citing works
Are human endogenous retroviruses pathogenic? An approach to testing the hypothesis
Young, G. R., Stoye, J. P., & Kassiotis, G. (2013) · BioEssays · doi:10.1002/bies.201300049 · Cited by 78 · see citing works
- Authors
- Ruprecht, K., Mayer, J., Sauter, M., Roemer, K., & Mueller-Lantzsch, N.
- Affiliations
- Universitätsklinikum des Saarlandes (DE)
- Venue
- Cellular and Molecular Life Sciences
- Published
- 2008-09-27
- Volume
- 65
- Issue
- 21
- Pages
- 3366-3382
- ISSN
- 1420-682X (ISSN-L)
- 1420-9071
- PMC
- PMC11131668
- OpenAlex
- W148958844
- Cited by
- 140
- References
- 0
- Citations by year
- 2026: 1 · 2025: 6 · 2024: 3 · 2023: 3 · 2022: 7 · 2021: 2 · 2020: 4 · 2019: 2 · 2018: 5 · 2017: 7 · 2016: 9 · 2015: 13 · 2014: 10 · 2013: 20 · 2012: 8
- FWCI
- 14.60
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Licence
- www.springer.com/tdm (tdm)
- Locations
- Cellular and Molecular Life Sciences (publishedVersion)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Life Sciences › Agricultural and Biological Sciences › Plant Science › Chromosomal and Genetic Variations
- Health Sciences › Veterinary › Small Animals › Infectious Diseases and Mycology
- Health Sciences › Medicine › Oncology › Viral-associated cancers and disorders
- Keywords
- endogenous retroviruses, human endogenous retroviruses, carcinogenesis, cancer, germ cell tumors, insertional mutagenesis, tumor surveillance, retroviral infection, germline transmission, malignant transformation
- MeSH terms
- Animals, Cell Transformation, Viral, Cocarcinogenesis, Female, Humans, Immunologic Surveillance, Male, Mammals, Models, Biological, Neoplasms, Proto-Oncogenes, Proviruses, Retroviridae Infections, Tumor Virus Infections, Retroviridae Proteins, Oncogenic, Gene Expression Regulation, Viral, Gene Expression Regulation, Neoplastic, Virus Integration, Tumor Escape, Endogenous Retroviruses, Host-Pathogen Interactions
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