Laccases: a never-ending story
Open accessAbstract
Laccases (benzenediol:oxygen oxidoreductases, EC 1.10.3.2) are blue multicopper oxidases that catalyze the oxidation of an array of aromatic substrates concomitantly with the reduction of molecular oxygen to water. In fungi, laccases carry out a variety of physiological roles during their life cycle. These enzymes are being increasingly evaluated for a variety of biotechnological applications due to their broad substrate range. In this review, the most recent studies on laccase structural features and catalytic mechanisms along with analyses of their expression are reported and examined with the aim of contributing to the discussion on their structure-function relationships. Attention has also been paid to the properties of enzymes endowed with unique characteristics and to fungal laccase multigene families and their organization.
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The variations in the redox potential of CuT1 observed among laccases cannot be attributed to a single structural characteristic; it is the sum of factors such as CuT1 coordination geometry and the nature of the waste that influence solvent accessibility, hydrogen bonds and dielectric anisotropy.
“Overall, the variations in the redox potential of CuT1 observed among laccases cannot be attributed to a single structural characteristic; it is the sum of factors such as the CuT1 coordination geometry and the nature of the waste that influence the accessibility of the solvent, the hydrogen bonds and the dielectric anisotropy [199].”
From A Brief History of Colour, the Environmental Impact of Synthetic Dyes and Removal by Using Laccases (2021) · cites this paper as [199]
Cites
Multicopper oxidases and oxygenases
Solomon, E. I., Sundaram, U. M., & Machonkin, T. E. (1996) · Chemical Reviews · doi:10.1021/cr950046o · Cited by 3,664 · see citing works
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A Brief History of Colour, the Environmental Impact of Synthetic Dyes and Removal by Using Laccases
Ardila-Leal, L. D., Poutou-Piñales, R. A., Pedroza-Rodríguez, A. M., & Quevedo-Hidalgo, B. E. (2021) · Molecules · doi:10.3390/molecules26133813 · Cited by 544 · see citing works
Prospects for microbiological solutions to environmental pollution with plastics
Krueger, M. C., Harms, H., & Schlosser, D. (2015) · Applied Microbiology and Biotechnology · doi:10.1007/s00253-015-6879-4 · Cited by 534 · see citing works
Biocatalysis with Laccases: An Updated Overview
Bassanini, I., Ferrandi, E. E., Riva, S., & Monti, D. (2020) · Catalysts · doi:10.3390/catal11010026 · Cited by 139 · see citing works
Yeast Hosts for the production of recombinant laccases: A review
Antošová, Z., & Sychrová, H. (2016) · Molecular Biotechnology · doi:10.1007/s12033-015-9910-1 · Cited by 74 · see citing works
Li, S., Tang, B., Liu, Y., Chen, A., Tang, W., & Wei, S. (2016) · Biocatalysis and Agricultural Biotechnology · doi:10.1016/j.bcab.2016.10.008 · Cited by 34 · see citing works
Dhanraj, N. D., Sreelakshmi, U. P., Sneha, P., & Jisha, M. S. (2025) · Process Biochemistry · doi:10.1016/j.procbio.2025.03.018 · Cited by 8 · see citing works
- Authors
- Giardina, P., Faraco, V., Pezzella, C., Piscitelli, A., Vanhulle, S., & Sannia, G.
- Affiliations
- University of Naples Federico II (IT)
- UCLouvain (BE)
- Corresponding author
- Giardina, Paola
- Venue
- Cellular and Molecular Life Sciences
- Published
- 2009-10-22
- Volume
- 67
- Issue
- 3
- Pages
- 369-385
- ISSN
- 1420-682X (ISSN-L)
- 1420-9071
- PMC
- PMC11115910
- OpenAlex
- W1996350754
- Cited by
- 1,007
- References
- 1
- Citations by year
- 2026: 31 · 2025: 54 · 2024: 62 · 2023: 70 · 2022: 74 · 2021: 79 · 2020: 70 · 2019: 86 · 2018: 49 · 2017: 59 · 2016: 69 · 2015: 81 · 2014: 60 · 2013: 53 · 2012: 47
- FWCI
- 3.14
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Licence
- www.springer.com/tdm (tdm)
- Locations
- Cellular and Molecular Life Sciences (publishedVersion)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- Digital Access to Libraries (submittedVersion)
- Funders
- Ministero dell'Università e della Ricerca
- Topics
- Life Sciences › Agricultural and Biological Sciences › Plant Science › Enzyme-mediated dye degradation
- Physical Sciences › Chemistry › Inorganic Chemistry › Metal-Catalyzed Oxygenation Mechanisms
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Enzyme Catalysis and Immobilization
- Keywords
- laccase, fungal laccase
- MeSH terms
- Amino Acid Sequence, Copper, Fungi, Molecular Sequence Data, Oxidation-Reduction, Structure-Activity Relationship, Sequence Alignment, Sequence Homology, Amino Acid, Catalytic Domain, Laccase
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