Crossing paths: interactions between the cell death machinery and growth factor survival signals
Open accessAbstract
Cytokines and growth factors play a crucial role in the maintenance of haematopoietic homeostasis. They transduce signals that regulate the competing commitments of haematopoietic stem cells, quiescence or proliferation, retention of stem cell pluripotency or differentiation, and survival or demise. When the balance between these commitments and the requirements of the organisms is disturbed, particularly when it favours survival and proliferation, cancer may result. Cell death provoked by loss of growth factor signalling is regulated by the Bcl-2 family of apoptosis regulators, and thus survival messages transduced by growth factors must regulate the activity of these proteins. Many aspects of direct interactions between cytokine signalling and regulation of apoptosis remain elusive. In this review, we explore the mechanisms by which cytokines, in particular Interleukin-3 and granulocyte-macrophage colony-stimulating factor, promote cell survival and suppress apoptosis as models of how cytokine signalling and apoptotic pathways intersect.
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Intrinsic apoptosis is initiated by microenvironmental perturbations including growth factor withdrawal, DNA damage, ER stress, ROS overload, replication stress, microtubular alterations or mitotic defects.
“Intrinsic apoptosis is a form of RCD initiated by a variety of microenvironmental perturbations including (but not limited to) growth factor withdrawal, DNA damage, endoplasmic reticulum (ER) stress, reactive oxygen species (ROS) overload, replication stress, microtubular alterations or mitotic defects [29–34].”
From Molecular mechanisms of cell death: recommendations of the nomenclature committee on cell death 2018. (2018) · cites this paper as [34]
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References 123 · Cited by 85
- Authors
- Brumatti, G., Salmanidis, M., & Ekert, P. G.
- Affiliations
- Royal Children's Hospital (AU)
- Corresponding author
- Brumatti, Gabriela
- ORCID
- Ekert, Paul G.
- Venue
- Cellular and Molecular Life Sciences
- Published
- 2010-02-16
- Volume
- 67
- Issue
- 10
- Pages
- 1619-1630
- ISSN
- 1420-682X (ISSN-L)
- 1420-9071
- PMC
- PMC11115775
- OpenAlex
- W2072461625
- Cited by
- 85
- References
- 123
- Citations by year
- 2026: 4 · 2025: 4 · 2024: 7 · 2023: 17 · 2022: 5 · 2021: 10 · 2020: 6 · 2019: 5 · 2018: 4 · 2017: 3 · 2015: 2 · 2014: 6 · 2013: 2 · 2012: 6
- FWCI
- 0.34
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Licence
- www.springer.com/tdm (tdm)
- Locations
- Cellular and Molecular Life Sciences (publishedVersion)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Cell death mechanisms and regulation
- Health Sciences › Medicine › Oncology › Cancer-related Molecular Pathways
- Health Sciences › Medicine › Oncology › Cytokine Signaling Pathways and Interactions
- Keywords
- apoptosis, cell survival signaling, cytokine signaling, growth factor signaling, Bcl-2 family proteins, hematopoietic stem cells, interleukin-3, GM-CSF, stem cell quiescence
- MeSH terms
- Animals, Cell Survival, Humans, Neoplasms, Signal Transduction, Cell Death, Proto-Oncogene Proteins c-bcl-2, Intercellular Signaling Peptides and Proteins
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