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Cited by 157RNA Research and SplicingRNA regulation and diseaseCytokine Signaling Pathways and Interactions

Post-transcriptional control during chronic inflammation and cancer: a focus on AU-rich elements

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Khabar, Khalid S. A.·2010·Cellular and Molecular Life Sciences
DOI 10.1007/s00018-010-0383-xPMC PMC2921490
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Abstract

A considerable number of genes that code for AU-rich mRNAs including cytokines, growth factors, transcriptional factors, and certain receptors are involved in both chronic inflammation and cancer. Overexpression of these genes is affected by aberrations or by prolonged activation of several signaling pathways. AU-rich elements (ARE) are important cis-acting short sequences in the 3'UTR that mediate recognition of an array of RNA-binding proteins and affect mRNA stability and translation. This review addresses the cellular and molecular mechanisms that are common between inflammation and cancer and that also govern ARE-mediated post-transcriptional control. The first part examines the role of the ARE-genes in inflammation and cancer and sequence characteristics of AU-rich elements. The second part addresses the common signaling pathways in inflammation and cancer that regulate the ARE-mediated pathways and how their deregulations affect ARE-gene regulation and disease outcome.

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  • ARE motifs are typically found in short-lived transcripts encoding proteins with diverse functions such as cellular proliferation, differentiation, transcription, RNA metabolism, inflammation, and stress-response.

    “ARE motifs are typically found in short-lived transcripts encoding proteins with diverse functions such as cellular proliferation, differentiation, transcription, RNA metabolism, inflammation, and stress-response (Bakheet et al. 2006; Khabar 2010).”

    From Emerging complexity of the HuD/ELAVl4 gene; implications for neuronal development, function, and dysfunction (2013) · cites this paper as Khabar 2010

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  1. [1]Halees AS El-Badrawi R Khabar KS ARED organism: expansion of ARED reveals AU-rich element cluster variations between human and mouse Nucleic Acids Res 2008 36 D137 D140 17984078 PMC2238997
  2. [2]Bakheet T Williams BR Khabar KS ARED 3.0: the large and diverse AU-rich transcriptome Nucleic Acids Res 2006 34 D111 D114 16381826 PMC1347415
  3. [3]Yang E Van Nimwegen E Zavolan M Rajewsky N Schroeder M Magnasco M Darnell JE Jr Decay rates of human mRNAs: correlation with functional characteristics and sequence attributes Genome Res 2003 13 1863 1872 12902380 PMC403777
  4. [4]Blackshear PJ Tristetraprolin and other CCCH tandem zinc-finger proteins in the regulation of mRNA turnover Biochem Soc Trans 2002 30 945 952 12440952
  5. [5]Chou CF Mulky A Maitra S Lin WJ Gherzi R Kappes J Chen CY Tethering KSRP, a decay-promoting AU-rich element-binding protein, to mRNAs elicits mRNA decay Mol Cell Biol 2006 26 3695 3706 16648466 PMC1489004
  6. [6]Schmidlin M Lu M Leuenberger SA Stoecklin G Mallaun M Gross B Gherzi R Hess D Hemmings BA Moroni C The ARE-dependent mRNA-destabilizing activity of BRF1 is regulated by protein kinase B EMBO J 2004 23 4760 4769 15538381 PMC535089
  7. [7]Barreau C Paillard L Osborne HB AU-rich elements and associated factors: are there unifying principles? Nucleic Acids Res 2005 33 7138 7150 16391004 PMC1325018
  8. [8]Kontoyiannis D Pasparakis M Pizarro TT Cominelli F Kollias G Impaired on/off regulation of TNF biosynthesis in mice lacking TNF AU- rich elements: implications for joint and gut-associated immunopathologies Immunity 1999 10 387 398 10204494
  9. [9]Taylor GA Carballo E Lee DM Lai WS Thompson MJ Patel DD Schenkman DI Gilkeson GS Broxmeyer HE Haynes BF Blackshear PJ A pathogenetic role for TNF alpha in the syndrome of cachexia, arthritis, and autoimmunity resulting from tristetraprolin (TTP) deficiency Immunity 1996 4 445 454 8630730
  10. [10]Carballo E Lai WS Blackshear PJ Feedback inhibition of macrophage tumor necrosis factor-alpha production by tristetraprolin Science 1998 281 1001 1005 9703499
  11. [11]Balkwill F Tumour necrosis factor and cancer Nat Rev Cancer 2009 9 361 371 19343034
  12. [12]Pikarsky E Porat RM Stein I Abramovitch R Amit S Kasem S Gutkovich-Pyest E Urieli-Shoval S Galun E Ben-Neriah Y NF-kappaB functions as a tumour promoter in inflammation-associated cancer Nature 2004 431 461 466 15329734
  13. [13]Popivanova BK Kitamura K Wu Y Kondo T Kagaya T Kaneko S Oshima M Fujii C Mukaida N Blocking TNF-alpha in mice reduces colorectal carcinogenesis associated with chronic colitis J Clin Invest 2008 118 560 570 18219394 PMC2213370
  14. [14]Egberts JH Cloosters V Noack A Schniewind B Thon L Klose S Kettler B von Forstner C Kneitz C Tepel J Adam D Wajant H Kalthoff H Trauzold A Anti-tumor necrosis factor therapy inhibits pancreatic tumor growth and metastasis Cancer Res 2008 68 1443 1450 18316608
  15. [15]Kulbe H Thompson R Wilson JL Robinson S Hagemann T Fatah R Gould D Ayhan A Balkwill F The inflammatory cytokine tumor necrosis factor-alpha generates an autocrine tumor-promoting network in epithelial ovarian cancer cells Cancer Res 2007 67 585 592 17234767 PMC2679985
  16. [16]Liu RY Fan C Liu G Olashaw NE Zuckerman KS Activation of p38 mitogen-activated protein kinase is required for tumor necrosis factor-alpha -supported proliferation of leukemia and lymphoma cell lines J Biol Chem 2000 275 21086 21093 10783388
  17. [17]Bates RC Mercurio AM Tumor necrosis factor-alpha stimulates the epithelial-to-mesenchymal transition of human colonic organoids Mol Biol Cell 2003 14 1790 1800 12802055 PMC165077
  18. [18]Popivanova BK Kostadinova FI Furuichi K Shamekh MM Kondo T Wada T Egashira K Mukaida N Blockade of a chemokine, CCL2, reduces chronic colitis-associated carcinogenesis in mice Cancer Res 2009 69 7884 7892 19773434
  19. [19]Tsujii M Kawano S Tsuji S Sawaoka H Hori M DuBois RN Cyclooxygenase regulates angiogenesis induced by colon cancer cells Cell 1998 93 705 716 9630216
  20. [20]Sawaoka H Tsuji S Tsujii M Gunawan ES Sasaki Y Kawano S Hori M Cyclooxygenase inhibitors suppress angiogenesis and reduce tumor growth in vivo Lab Invest 1999 79 1469 1477 10616198
  21. [21]Li G Yang T Yan J Cyclooxygenase-2 increased the angiogenic and metastatic potential of tumor cells Biochem Biophys Res Commun 2002 299 886 890 12470662
  22. [22]Franco S Stefania V Miquel S Vincenzo A Giuseppe S Egidio S Alessandro R Andreas S Alberto M Julian P Seppo YH Claudio F Silvio D VEGF-A links angiogenesis and inflammation in inflammatory bowel disease pathogenesis Gastroenterology 2009 136 585 595 19013462
  23. [23]Liu LX Lu H Luo Y Date T Belanger AJ Vincent KA Akita GY Goldberg M Cheng SH Gregory RJ Jiang C Stabilization of vascular endothelial growth factor mRNA by hypoxia-inducible factor 1 Biochem Biophys Res Commun 2002 291 908 914 11866451
  24. [24]Scortegagna M Cataisson C Martin RJ Hicklin DJ Schreiber RD Yuspa SH Arbeit JM HIF-1{alpha} regulates epithelial inflammation by cell autonomous NF{kappa}B activation and paracrine stromal remodeling Blood 2008 111 3343 3354 18199827 PMC2275004
  25. [25]Cramer T Yamanishi Y Clausen BE Forster I Pawlinski R Mackman N Haase VH Jaenisch R Corr M Nizet V Firestein GS Gerber HP Ferrara N Johnson RS HIF-1alpha is essential for myeloid cell-mediated inflammation Cell 2003 112 645 657 12628185 PMC4480774
  26. [26]Andreasen PA Egelund R Petersen HH The plasminogen activation system in tumor growth, invasion, and metastasis Cell Mol Life Sci 2000 57 25 40 10949579 PMC11146824
  27. [27]Shi Q Abbruzzese JL Huang S Fidler IJ Xiong Q Xie K Constitutive and inducible interleukin 8 expression by hypoxia and acidosis renders human pancreatic cancer cells more tumorigenic and metastatic Clin Cancer Res 1999 5 3711 3721 10589791
  28. [28]Inoue K Slaton JW Eve BY Kim SJ Perrotte P Balbay MD Yano S Bar-Eli M Radinsky R Pettaway CA Dinney CP Interleukin 8 expression regulates tumorigenicity and metastases in androgen-independent prostate cancer Clin Cancer Res 2000 6 2104 2119 10815938
  29. [29]Haghnegahdar H Du J Wang D Strieter RM Burdick MD Nanney LB Cardwell N Luan J Shattuck-Brandt R Richmond A The tumorigenic and angiogenic effects of MGSA/GRO proteins in melanoma J Leukoc Biol 2000 67 53 62 10647998 PMC2669312
  30. [30]Hussain SP He P Subleski J Hofseth LJ Trivers GE Mechanic L Hofseth AB Bernard M Schwank J Nguyen G Mathe E Djurickovic D Haines D Weiss J Back T Gruys E Laubach VE Wiltrout RH Harris CC Nitric oxide is a key component in inflammation-accelerated tumorigenesis Cancer Res 2008 68 7130 7136 18757428 PMC2576291
  31. [32]Lagnado CA Brown CY Goodall GJ AUUUA is not sufficient to promote poly(A) shortening and degradation of an mRNA: the functional sequence within AU-rich elements may be UUAUUUA(U/A)(U/A) Mol Cell Biol 1994 14 7984 7995 7969138 PMC359337
  32. [33]Lewis T Gueydan C Huez G Toulme JJ Kruys V Mapping of a minimal AU-rich sequence required for lipopolysaccharide- induced binding of a 55-kDa protein on tumor necrosis factor-alpha mRNA J Biol Chem 1998 273 13781 13786 9593721
  33. [34]Zubiaga AM Belasco JG Greenberg ME The nonamer UUAUUUAUU is the key AU-rich sequence motif that mediates mRNA degradation Mol Cell Biol 1995 15 2219 2230 7891716 PMC230450
  34. [35]Lai WS Carrick DM Blackshear PJ Influence of nonameric AU-rich tristetraprolin-binding sites on mRNA deadenylation and turnover J Biol Chem 2005 280 34365 34377 16061475
  35. [36]Bakheet T Frevel M Williams BR Greer W Khabar KS ARED: human AU-rich element-containing mRNA database reveals an unexpectedly diverse functional repertoire of encoded proteins Nucleic Acids Res 2001 29 246 254 11125104 PMC29778
  36. [37]Frevel MA Bakheet T Silva AM Hissong JG Khabar KS Williams BR p38 Mitogen-activated protein kinase-dependent and -independent signaling of mRNA stability of AU-rich element-containing transcripts Mol Cell Biol 2003 23 425 436 12509443 PMC151534
  37. [38]Raghavan A Dhalla M Bakheet T Ogilvie RL Vlasova IA Khabar KS Williams BR Bohjanen PR Patterns of coordinate down-regulation of ARE-containing transcripts following immune cell activation Genomics 2004 84 1002 1013 15533717
  38. [40]Ray D Kazan H Chan ET Castillo LP Chaudhry S Talukder S Blencowe BJ Morris Q Hughes TR Rapid and systematic analysis of the RNA recognition specificities of RNA-binding proteins Nat Biotechnol 2009 27 667 670 19561594
  39. [41]Meisner NC Hackermuller J Uhl V Aszodi A Jaritz M Auer M mRNA openers and closers: modulating AU-rich element-controlled mRNA stability by a molecular switch in mRNA secondary structure Chembiochem 2004 5 1432 1447 15457527
  40. [42]Hackermuller J Meisner NC Auer M Jaritz M Stadler PF The effect of RNA secondary structures on RNA-ligand binding and the modifier RNA mechanism: a quantitative model Gene 2005 345 3 12 15716109
  41. [44]Park-Lee S Kim S Laird-Offringa IA Characterization of the interaction between neuronal RNA-binding protein HuD and AU-rich RNA J Biol Chem 2003 278 39801 39808 12900401
  42. [45]Brewer BY Malicka J Blackshear PJ Wilson GM RNA sequence elements required for high affinity binding by the zinc-finger domain of tristetraprolin: conformational changes coupled to the bipartite nature of Au-rich MRNA-destabilizing motifs J Biol Chem 2004 279 27870 27877 15117938
  43. [46]Worthington MT Pelo JW Sachedina MA Applegate JL Arseneau KO Pizarro TT RNA-binding properties of the AU-rich element-binding recombinant Nup475/TIS11/tristetraprolin protein J Biol Chem 2002 277 48558 48564 12324455
  44. [47]Mazan-Mamczarz K Kuwano Y Zhan M White EJ Martindale JL Lal A Gorospe M Identification of a signature motif in target mRNAs of RNA-binding protein AUF1 Nucleic Acids Res 2009 37 204 214 19033365 PMC2615618
  45. [48]Lopez de Silanes I Galban S Martindale JL Yang X Mazan-Mamczarz K Indig FE Falco G Zhan M Gorospe M Identification and functional outcome of mRNAs associated with RNA-binding protein TIA-1 Mol Cell Biol 2005 25 9520 9531 16227602 PMC1265820
  46. [49]Andersen JB Mazan-Mamczarz K Zhan M Gorospe M Hassel BA Ribosomal protein mRNAs are primary targets of regulation in RNase-L-induced senescence RNA Biol 2009 6 305 315 19411840 PMC2752476
  47. [50]Forte GI Scola L Bellavia D Vaccarino L Sanacore M Sisino G Scazzone C Caruso C Barbieri R Lio D Characterization of two alternative Interleukin(IL)-10 5’UTR mRNA sequences, induced by lipopolysaccharide (LPS) stimulation of peripheral blood mononuclear cells Mol Immunol 2009 46 2161 2166 19477525
  48. [51]Paste M Huez G Kruys V Deadenylation of interferon-beta mRNA is mediated by both the AU-rich element in the 3’-untranslated region and an instability sequence in the coding region Eur J Biochem 2003 270 1590 1597 12654014
  49. [52]Prechtel AT Chemnitz J Schirmer S Ehlers C Langbein-Detsch I Stulke J Dabauvalle MC Kehlenbach RH Hauber J Expression of CD83 is regulated by HuR via a novel cis-active coding region RNA element J Biol Chem 2006 281 10912 10925 16484227
  50. [53]Al-Zoghaibi F Ashour T Al-Ahmadi W Abulleef H Demirkaya O Khabar KS Bioinformatics and experimental derivation of an efficient hybrid 3’ untranslated region and use in expression active linear DNA with minimum poly(A) region Gene 2007 391 130 139 17258873
  51. [54]Mukherjee N Lager PJ Friedersdorf MB Thompson MA Keene JD Coordinated posttranscriptional mRNA population dynamics during T-cell activation Mol Syst Biol 2009 5 288 19638969 PMC2724974
  52. [55]Stoecklin G Tenenbaum SA Mayo T Chittur SV George AD Baroni TE Blackshear PJ Anderson P Genome-wide analysis identifies interleukin-10 mRNA as target of tristetraprolin J Biol Chem 2008 283 11689 11699 18256032 PMC2431067
  53. [56]Jing Q Huang S Guth S Zarubin T Motoyama A Chen J Di Padova F Lin SC Gram H Han J Involvement of microRNA in AU-rich element-mediated mRNA instability Cell 2005 120 623 634 15766526
  54. [58]Sandberg R Neilson JR Sarma A Sharp PA Burge CB Proliferating cells express mRNAs with shortened 3’ untranslated regions and fewer microRNA target sites Science 2008 320 1643 1647 18566288 PMC2587246
  55. [59]Akashi M Shaw G Hachiya M Elstner E Suzuki G Koeffler P Number and location of AUUUA motifs: role in regulating transiently expressed RNAs Blood 1994 83 3182 3187 8193353
  56. [60]Blackshear PJ Lai WS Kennington EA Brewer G Wilson GM Guan X Zhou P Characteristics of the interaction of a synthetic human tristetraprolin tandem zinc-finger peptide with AU-rich element-containing RNA substrates J Biol Chem 2003 278 19947 19955 12639954
  57. [61]Vlasova IA Tahoe NM Fan D Larsson O Rattenbacher B Sternjohn JR Vasdewani J Karypis G Reilly CS Bitterman PB Bohjanen PR Conserved GU-rich elements mediate mRNA decay by binding to CUG-binding protein 1 Mol Cell 2008 29 263 270 18243120 PMC2367162
  58. [62]Kruys V Wathelet M Poupart P Contreras R Fiers W Content J Huez G The 3’ untranslated region of the human interferon-beta mRNA has an inhibitory effect on translation Proc Natl Acad Sci USA 1987 84 6030 6034 3476924 PMC299001
  59. [63]Kruys V Marinx O Shaw G Deschamps J Huez G Translational blockade imposed by cytokine-derived UA-rich sequences Science 1989 245 852 855 2672333
  60. [65]Cao H Deterding LJ Blackshear PJ Phosphorylation site analysis of the anti-inflammatory and mRNA-destabilizing protein tristetraprolin Expert Rev Proteomics 2007 4 711 726 18067411 PMC2674331
  61. [66]Lai WS Carballo E Strum JR Kennington EA Phillips RS Blackshear PJ Evidence that tristetraprolin binds to AU-Rich elements and promotes the deadenylation and destabilization of tumor necrosis factor alpha mRNA Mol Cell Biol 1999 19 4311 4323 10330172 PMC104391
  62. [67]Taylor GA Thompson MJ Lai WS Blackshear PJ Mitogens stimulate the rapid nuclear to cytosolic translocation of tristetraprolin, a potential zinc-finger transcription factor Mol Endocrinol 1996 10 140 146 8825554
  63. [68]Carballo E Lai WS Blackshear PJ Evidence that tristetraprolin is a physiological regulator of granulocyte-macrophage colony stimulating factor messenger RNA deadenylation and stability Blood 2000 95 1891 1899 10706852
  64. [69]Stoecklin G Ming X-F Looser R Moroni C Somatic mRNA turnover mutants implicate tristetraprolin in the interleukin-3 mRNA degradation pathway Mol Cell Biol 2000 20 3753 3763 10805719 PMC85689
  65. [70]Sawaoka H Dixon DA Oates JA Boutaud O Tristetraprolin binds to the 3’-Untranslated Region of cyclooxygenase-2 mRNA. A polyadenylation variant in a cancer cell line lacks the binding site J Biol Chem 2003 278 13928 13935 12578839
  66. [71]Young LE Sanduja S Bemis-Standoli K Pena EA Price RL Dixon DA The mRNA-binding proteins HuR and tristetraprolin regulate cyclooxygenase 2 expression during colon carcinogenesis Gastroenterology 2009 136 1669 1679 19208339 PMC3742387
  67. [72]Essafi-Benkhadir K Onesto C Stebe E Moroni C Pages G Tristetraprolin inhibits ras-dependent tumor vascularization by inducing vascular endothelial growth factor mRNA degradation Mol Biol Cell 2007 18 4648 4658 17855506 PMC2043565
  68. [73]Al-Ahmadi W Al-Ghamdi M Al-Haj L Al-Saif M Khabar KS Alternative polyadenylation variants of the RNA-binding protein, HuR: abundance, role of AU-rich elements and auto-Regulation Nucleic Acids Res 2009 37 3612 3624 19359363 PMC2699509
  69. [74]Lai WS Parker JS Grissom SF Stumpo DJ Blackshear PJ Novel mRNA targets for tristetraprolin (ttp) identified by global analysis of stabilized transcripts in TTP-deficient fibroblasts Mol Cell Biol 2006 26 9196 9208 17030620 PMC1698545
  70. [75]Ma WJ Cheng S Campbell C Wright A Furneaux H Cloning and characterization of HuR, a ubiquitously expressed Elav-like protein J Biol Chem 1996 271 8144 8151 8626503
  71. [76]Atasoy U Watson J Patel D Keene JD ELAV protein HuA (HuR) can redistribute between nucleus and cytoplasm and is upregulated during serum stimulation and T cell activation J Cell Sci 1998 111 3145 3156 9763509
  72. [77]Levine TD Gao F King PH Andrews LG Keene JD Hel-N1: an autoimmune RNA-binding protein with specificity for 3’ uridylate-rich untranslated regions of growth factor mRNAs Mol Cell Biol 1993 13 3494 3504 8497264 PMC359819
  73. [78]Keene JD Why is Hu where? Shuttling of early-response-gene messenger RNA subsets Proc Natl Acad Sci USA 1999 96 5 7 9874760 PMC33538
  74. [79]Wang W Furneaux H Cheng H Caldwell MC Hutter D Liu Y Holbrook N Gorospe M HuR regulates p21 mRNA stabilization by UV light Mol Cell Biol 2000 20 760 769 10629032 PMC85192
  75. [80]Lal A Mazan-Mamczarz K Kawai T Yang X Martindale JL Gorospe M Concurrent versus individual binding of HuR and AUF1 to common labile target mRNAs EMBO J 2004 23 3092 3102 15257295 PMC514922
  76. [81]Casolaro V Fang X Tancowny B Fan J Wu F Srikantan S Asaki SY Fanis U Huang SK Gorospe M Atasoy UX Stellato C Posttranscriptional regulation of IL-13 in T cells: role of the RNA-binding protein HuR J Allergy Clin Immunol 2008 121 853 859 18279945 PMC2666917
  77. [82]Lopez de Silanes I Fan J Galban CJ Spencer RG Becker KG Gorospe M Global analysis of HuR-regulated gene expression in colon cancer systems of reducing complexity Gene Expr 2004 12 49 59 15473260 PMC6009105
  78. [83]Papadaki O Milatos S Grammenoudi S Mukherjee N Keene JD Kontoyiannis DL Control of thymic T cell maturation, deletion and egress by the RNA-binding protein HuR J Immunol 2009 182 6779 6788 19454673
  79. [84]Katsanou V Milatos S Yiakouvaki A Sgantzis N Kotsoni A Alexiou M Harokopos V Aidinis V Hemberger M Kontoyiannis DL The RNA-binding protein Elavl1/HuR is essential for placental branching morphogenesis and embryonic development Mol Cell Biol 2009 29 2762 2776 19307312 PMC2682039
  80. [85]Ghosh M Aguila HL Michaud J Ai Y Wu MT Hemmes A Ristimaki A Guo C Furneaux H Hla T Essential role of the RNA-binding protein HuR in progenitor cell survival in mice J Clin Invest 2009 119 3530 3543 19884656 PMC2786787
  81. [86]Houseley J LaCava J Tollervey D RNA-quality control by the exosome Nat Rev Mol Cell Biol 2006 7 529 539 16829983
  82. [87]Gherzi R Trabucchi M Ponassi M Ruggiero T Corte G Moroni C Chen CY Khabar KS Andersen JS Briata P The RNA-binding protein KSRP promotes decay of beta-Catenin mRNA and is inactivated by PI3 K-AKT signaling PLoS Biol 2006 5 e5 17177604 PMC1702562
  83. [88]He C Schneider R 14–3-3sigma is a p37 AUF1-binding protein that facilitates AUF1 transport and AU-rich mRNA decay EMBO J 2006 25 3823 3831 16902409 PMC1553187
  84. [89]Sun L Stoecklin G Van Way S Hinkovska-Galcheva V Guo RF Anderson P Shanley TP Tristetraprolin (TTP)-14–3-3 complex formation protects TTP from dephosphorylation by protein phosphatase 2a and stabilizes tumor necrosis factor-alpha mRNA J Biol Chem 2007 282 3766 3777 17170118
  85. [90]Fenger-Gron M Fillman C Norrild B Lykke-Andersen J Multiple processing body factors and the ARE binding protein TTP activate mRNA decapping Mol Cell 2005 20 905 915 16364915
  86. [91]Lykke-Andersen J Wagner E Recruitment and activation of mRNA decay enzymes by two ARE-mediated decay activation domains in the proteins TTP and BRF-1 Genes Dev 2005 19 351 361 15687258 PMC546513
  87. [92]Stoecklin G Mayo T Anderson P ARE-mRNA degradation requires the 5’–3’ decay pathway EMBO Rep 2006 7 72 77 16299471 PMC1369226
  88. [93]Briata P Forcales SV Ponassi M Corte G Chen CY Karin M Puri PL Gherzi R p38-dependent phosphorylation of the mRNA decay-promoting factor KSRP controls the stability of select myogenic transcripts Mol Cell 2005 20 891 903 16364914
  89. [94]Briata P Ilengo C Corte G Moroni C Rosenfeld MG Chen CY Gherzi R The Wnt/beta-catenin– > Pitx2 pathway controls the turnover of Pitx2 and other unstable mRNAs Mol Cell 2003 12 1201 1211 14636578
  90. [95]Sureban SM Murmu N Rodriguez P May R Maheshwari R Dieckgraefe BK Houchen CW Anant S Functional antagonism between RNA-binding proteins HuR and CUGBP2 determines the fate of COX-2 mRNA translation Gastroenterology 2007 132 1055 1065 17383427
  91. [96]Linker K Pautz A Fechir M Hubrich T Greeve J Kleinert H Involvement of KSRP in the post-transcriptional regulation of human iNOS expression-complex interplay of KSRP with TTP and HuR Nucleic Acids Res 2005 33 4813 4827 16126846 PMC1192834
  92. [97]Wagner BJ DeMaria CT Sun Y Wilson GM Brewer G Structure and genomic organization of the human AUF1 gene: alternative pre-mRNA splicing generates four protein isoforms Genomics 1998 48 195 202 9521873
  93. [98]Gouble A Grazide S Meggetto F Mercier P Delsol G Morello D A new player in oncogenesis: AUF1/hnRNPD overexpression leads to tumorigenesis in transgenic mice Cancer Res 2002 62 1489 1495 11888925
  94. [99]Lu JY Sadri N Schneider RJ Endotoxic shock in AUF1 knockout mice mediated by failure to degrade proinflammatory cytokine mRNAs Genes Dev 2006 20 3174 3184 17085481 PMC1635151
  95. [100]Laroia G Cuesta R Brewer G Schneider RJ Control of mRNA decay by heat shock-ubiquitin-proteasome pathway Science 1999 284 499 502 10205060
  96. [101]Garnon J Lachance C Di Marco S Hel Z Marion D Ruiz MC Newkirk MM Khandjian EW Radzioch D Fragile X-related protein FXR1P regulates proinflammatory cytokine tumor necrosis factor expression at the post-transcriptional level J Biol Chem 2005 280 5750 5763 15548538
  97. [102]Steitz JA Vasudevan S miRNPs: versatile regulators of gene expression in vertebrate cells Biochem Soc Trans 2009 37 931 935 19754429
  98. [103]Porta C Larghi P Rimoldi M Totaro MG Allavena P Mantovani A Sica A Cellular and molecular pathways linking inflammation and cancer Immunobiology 2009 214 761 777 19616341
  99. [104]Lin Y Bai L Chen W Xu S The NF-kappaB activation pathways, emerging molecular targets for cancer prevention and therapy Expert Opin Ther Targets 2010 14 45 55 20001209 PMC3043547
  100. [105]Hartupee J Li X Hamilton T Interleukin 1alpha-induced NFkappaB activation and chemokine mRNA stabilization diverge at IRAK1 J Biol Chem 2008 283 15689 15693 18411265 PMC3259643
  101. [107]Gaestel M MAPKAP kinases—MKs—two’s company, three’s a crowd Nat Rev Mol Cell Biol 2006 7 120 130 16421520
  102. [108]Dhillon AS Hagan S Rath O Kolch W MAP kinase signalling pathways in cancer Oncogene 2007 26 3279 3290 17496922
  103. [109]Vivanco I Palaskas N Tran C Finn SP Getz G Kennedy NJ Jiao J Rose J Xie W Loda M Golub T Mellinghoff IK Davis RJ Wu H Sawyers CL Identification of the JNK signaling pathway as a functional target of the tumor suppressor PTEN Cancer Cell 2007 11 555 569 17560336
  104. [110]Korhonen R Linker K Pautz A Forstermann U Moilanen E Kleinert H Post-transcriptional regulation of human inducible nitric-oxide synthase expression by the Jun N-terminal kinase Mol Pharmacol 2007 71 1427 1434 17322004
  105. [111]Brook M Sully G Clark AR Saklatvala J Regulation of tumour necrosis factor alpha mRNA stability by the mitogen-activated protein kinase p38 signalling cascade FEBS Lett 2000 483 57 61 11033356
  106. [112]Holtmann H Winzen R Holland P Eickemeier S Hoffmann E Wallach D Malinin NL Cooper JA Resch K Kracht M Induction of interleukin-8 synthesis integrates effects on transcription and mRNA degradation from at least three different cytokine- or stress-activated signal transduction pathways Mol Cell Biol 1999 19 6742 6753 10490613 PMC84667
  107. [113]Montero L Nagamine Y Regulation by p38 mitogen-activated protein kinase of adenylate- and uridylate-rich element-mediated urokinase-type plasminogen activator (uPA) messenger RNA stability and uPA-dependent in vitro cell invasion Cancer Res 1999 59 5286 5293 10537311
  108. [114]Pages G Berra E Milanini J Levy AP Pouyssegur J Stress-activated protein kinases (JNK and p38/HOG) are essential for vascular endothelial growth factor mRNA stability [In Process Citation] J Biol Chem 2000 275 26484 26491 10849421
  109. [115]Wang SW Pawlowski J Wathen ST Kinney SD Lichenstein HS Manthey CL Cytokine mRNA decay is accelerated by an inhibitor of p38-mitogen-activated protein kinase Inflamm Res 1999 48 533 538 10563470
  110. [116]Winzen R Kracht M Ritter B Wilhelm A Chen CY Shyu AB MM Gaestel M Resch K Holtmann H The p38 MAP kinase pathway signals for cytokine-induced mRNA stabilization via MAP kinase-activated protein kinase 2 and an AU-rich region-targeted mechanism EMBO J 1999 18 4969 4980 10487749 PMC1171568
  111. [117]Green J Khabar KS Koo BC Williams BR Polyak SJ Stability of CXCL-8 and related AU-rich mRNAs in the context of hepatitis C virus replication in vitro J Infect Dis 2006 193 802 811 16479515
  112. [118]Datta S Novotny M Li X Tebo J Hamilton TA Toll IL-1 receptors differ in their ability to promote the stabilization of adenosine and uridine-rich elements containing mRNA J Immunol 2004 173 2755 2761 15294994
  113. [119]Novotny M Datta S Biswas R Hamilton T Functionally independent AU-rich sequence motifs regulate KC (CXCL1) mRNA J Biol Chem 2005 280 30166 30174 15994316
  114. [120]Deleault KM Skinner SJ Brooks SA Tristetraprolin regulates TNF TNF-[alpha] mRNA stability via a proteasome dependent mechanism involving the combined action of the ERK and p38 pathways Mol Immunol 2008 45 13 24 17606294
  115. [121]Ronkina N Kotlyarov A Dittrich-Breiholz O Kracht M Hitti E Milarski K Askew R Marusic S Lin LL Gaestel M Telliez JB The mitogen-activated protein kinase (MAPK)-activated protein kinases MK2 and MK3 cooperate in stimulation of tumor necrosis factor biosynthesis and stabilization of p38 MAPK Mol Cell Biol 2007 27 170 181 17030606 PMC1800641
  116. [122]Stoecklin G Stubbs T Kedersha N Wax S Rigby WF Blackwell TK Anderson P MK2-induced tristetraprolin:14–3-3 complexes prevent stress granule association and ARE-mRNA decay EMBO J 2004 23 1313 1324 15014438 PMC381421
  117. [123]Hitti E Iakovleva T Brook M Deppenmeier S Gruber AD Radzioch D Clark AR Blackshear PJ Kotlyarov A Gaestel M Mitogen-activated protein kinase-activated protein kinase 2 regulates tumor necrosis factor mRNA stability and translation mainly by altering tristetraprolin expression, stability, and binding to adenine/uridine-rich element Mol Cell Biol 2006 26 2399 2407 16508014 PMC1430282
  118. [124]Winzen R Thakur BK Dittrich-Breiholz O Shah M Redich N Dhamija S Kracht M Holtmann H Functional analysis of KSRP interaction with the AU-rich element of interleukin-8 and identification of inflammatory mRNA targets Mol Cell Biol 2007 27 8388 8400 17908789 PMC2169186
  119. [125]Neininger A Kontoyiannis D Kotlyarov A Winzen R Eckert R Volk HD Holtmann H Kollias G Gaestel M MK2 targets AU-rich elements and regulates biosynthesis of tumor necrosis factor and interleukin-6 independently at different post-transcriptional levels J Biol Chem 2002 277 3065 3068 11741878
  120. [126]Tudor C Marchese FP Hitti E Aubareda A Rawlinson L Gaestel M Blackshear PJ Clark AR Saklatvala J Dean JL The p38 MAPK pathway inhibits tristetraprolin-directed decay of interleukin-10 and pro-inflammatory mediator mRNAs in murine macrophages FEBS Lett 2009 583 1933 1938 19416727 PMC4798241
  121. [127]Ming XF Stoecklin G Lu M Looser R Moroni C Parallel and independent regulation of interleukin-3 mRNA turnover by phosphatidylinositol 3-kinase and p38 mitogen-activated protein kinase Mol Cell Biol 2001 21 5778 5789 11486017 PMC87297
  122. [128]Lafarga V Cuadrado A Lopez de Silanes I Bengoechea R Fernandez-Capetillo O Nebreda AR p38 Mitogen-activated protein kinase- and HuR-dependent stabilization of p21Cip1 mRNA mediates the G1/S checkpoint Mol Cell Biol 2009 29 4341 4351 19528229 PMC2725730
  123. [129]Tran H Maurer F Nagamine Y Stabilization of urokinase and urokinase receptor mRNAs by HuR is linked to its cytoplasmic accumulation induced by activated mitogen-activated protein kinase-activated protein kinase 2 Mol Cell Biol 2003 23 7177 7188 14517288 PMC230330
  124. [130]Dixon DA Tolley ND Bemis-Standoli K Martinez ML Weyrich AS Morrow JD Prescott SM Zimmerman GA Expression of COX-2 in platelet-monocyte interactions occurs via combinatorial regulation involving adhesion and cytokine signaling J Clin Invest 2006 116 2727 2738 16998585 PMC1570372
  125. [131]Clark A Dean J Tudor C Saklatvala J Post-transcriptional gene regulation by MAP kinases via AU-rich elements Front Biosci 2009 14 847 871 19273104
  126. [132]Sandler H Stoecklin G Control of mRNA decay by phosphorylation of tristetraprolin Biochem Soc Trans 2008 36 491 496 18481987
  127. [133]Kang S Denley A Vanhaesebroeck B Vogt PK Oncogenic transformation induced by the p110beta, -gamma, and -delta isoforms of class I phosphoinositide 3-kinase Proc Natl Acad Sci USA 2006 103 1289 1294 16432180 PMC1360601
  128. [134]Hirsch E Ciraolo E Ghigo A Costa C Taming the PI3 K team to hold inflammation and cancer at bay Pharmacol Ther 2008 118 192 205 18420279
  129. [135]Madge LA Pober JS A Phosphatidylinositol 3-kinase/akt pathway, activated by tumor necrosis factor or interleukin-1, inhibits apoptosis but does not activate NFκB in human endothelial cells J Biol Chem 2000 275 15458 15465 10748004
  130. [136]Stoecklin G Stoeckle P Lu M Muehlemann O Moroni C Cellular mutants define a common mRNA degradation pathway targeting cytokine AU-rich elements RNA 2001 7 1578 1588 11720287 PMC1370200
  131. [137]Yu W Murray NR Weems C Chen L Guo H Ethridge R Ceci JD Evers BM Thompson EA Fields AP Role of cyclooxygenase 2 in protein kinase C beta II-mediated colon carcinogenesis J Biol Chem 2003 278 11167 11174 12480928
  132. [138]Subbaramaiah K Marmao TP Dixon DA Dannenberg AJ Regulation of cyclooxygenase-2 mRNA stability by taxanes. Evidence for involvement of p38, MAPKAPK-2 and HuR J Biol Chem 2003 25 25 PMC6952618 31900374
  133. [139]Lee HK Jeong S Beta-catenin stabilizes cyclooxygenase-2 mRNA by interacting with AU-rich elements of 3’-UTR Nucleic Acids Res 2006 34 5705 5714 17040897 PMC1636482
  134. [140]Castellone MD Teramoto H Williams BO Druey KM Gutkind JS Prostaglandin E2 promotes colon cancer cell growth through a Gs-axin-beta-catenin signaling axis Science 2005 310 1504 1510 16293724
  135. [141]Kang MJ Ryu BK Lee MG Han J Lee JH Ha TK Byun DS Chae KS Lee BH Chun HS Lee KY Kim HJ Chi SG NF-kappaB activates transcription of the RNA-binding factor HuR, via PI3 K-AKT signaling, to promote gastric tumorigenesis Gastroenterology 2008 135 2030 2042 18824170
  136. [142]Dormoy-Raclet V Menard I Clair E Kurban G Mazroui R Di Marco S von Roretz C Pause A Gallouzi IE The RNA-binding protein HuR promotes cell migration and cell invasion by stabilizing the {beta}-actin mRNA in a U-rich-element-dependent manner Mol Cell Biol 2007 27 5365 5380 17548472 PMC1952093
  137. [143]Lopez de Silanes I Fan J Yang X Zonderman AB Potapova O Pizer ES Gorospe M Role of the RNA-binding protein HuR in colon carcinogenesis Oncogene 2003 22 7146 7154 14562043
  138. [145]Abdelmohsen K Srikantan S Kuwano Y Gorospe M miR-519 reduces cell proliferation by lowering RNA-binding protein HuR levels Proc Natl Acad Sci USA 2008 105 20297 20302 19088191 PMC2629338
  139. [146]Al-Ahmadi W Al-Haj L Al-Mohanna FA Silverman RH Khabar KS RNase L downmodulation of the RNA-binding protein, HuR, and cellular growth Oncogene 2009 28 1782 1791 19252527 PMC3071643
  140. [147]Denkert C Weichert W Pest S Koch I Licht D Kobel M Reles A Sehouli J Dietel M Hauptmann S Overexpression of the embryonic-lethal abnormal vision-like protein HuR in ovarian carcinoma is a prognostic factor and is associated with increased cyclooxygenase 2 expression Cancer Res 2004 64 189 195 14729623
  141. [148]Mrena J Wiksten JP Thiel A Kokkola A Pohjola L Lundin J Nordling S Ristimaki A Haglund C Cyclooxygenase-2 is an independent prognostic factor in gastric cancer and its expression is regulated by the messenger RNA stability factor HuR Clin Cancer Res 2005 11 7362 7368 16243808
  142. [149]Heinonen M Bono P Narko K Chang SH Lundin J Joensuu H Furneaux H Hla T Haglund C Ristimaki A Cytoplasmic HuR expression is a prognostic factor in invasive ductal breast carcinoma Cancer Res 2005 65 2157 2161 15781626
  143. [150]Niesporek S Kristiansen G Thoma A Weichert W Noske A Buckendahl AC Jung K Stephan C Dietel M Denkert C Expression of the ELAV-like protein HuR in human prostate carcinoma is an indicator of disease relapse and linked to COX-2 expression Int J Oncol 2008 32 341 347 18202756
  144. [151]Nabors LB Gillespie GY Harkins L King PH HuR, a RNA stability factor, is expressed in malignant brain tumors and binds to adenine- and uridine-rich elements within the 3’ untranslated regions of cytokine and angiogenic factor mRNAs Cancer Res 2001 61 2154 2161 11280780
  145. [152]Blaxall BC Dwyer-Nield LD Bauer AK Bohlmeyer TJ Malkinson AM Port JD Differential expression and localization of the mRNA-binding proteins, AU-rich element mRNA-binding protein (AUF1) and Hu antigen R (HuR), in neoplastic lung tissue Mol Carcinog 2000 28 76 83 10900464
  146. [153]Brennan SE Kuwano Y Alkharouf N Blackshear PJ Gorospe M Wilson GM The mRNA-destabilizing protein tristetraprolin is suppressed in many cancers, altering tumorigenic phenotypes and patient prognosis Cancer Res 2009 69 5168 5176 19491267 PMC2724875
  147. [154]Wang J Zhao W Guo Y Zhang B Xie Q Xiang D Gao J Wang B Chen Z The expression of RNA-binding protein HuR in non-small cell lung cancer correlates with vascular endothelial growth factor-C expression and lymph node metastasis Oncology 2009 76 420 429 19420963
  148. [155]Kanies CL Smith JJ Kis C Schmidt C Levy S Khabar KS Morrow J Deane N Dixon DA Beauchamp RD Oncogenic Ras and transforming growth factor-beta synergistically regulate AU-rich element-containing mRNAs during epithelial to mesenchymal transition Mol Cancer Res 2008 6 1124 1136 18644977 PMC2572152
  149. [156]Dixon DA Tolley ND King PH Nabors LB McIntyre TM Zimmerman GA Prescott SM Altered expression of the mRNA stability factor HuR promotes cyclooxygenase-2 expression in colon cancer cells J Clin Invest 2001 108 1657 1665 11733561 PMC200983
  150. [157]Oyesanya RA Lee ZP Wu J Chen J Song Y Mukherjee A Dent P Kordula T Zhou H Fang X Transcriptional and post-transcriptional mechanisms for lysophosphatidic acid-induced cyclooxygenase-2 expression in ovarian cancer cells FASEB J 2008 22 2639 2651 18362203 PMC2493458
  151. [158]Lim SJ Kim HJ Kim JY Park K Lee CM Expression of HuR is associated with increased cyclooxygenase-2 expression in uterine cervical carcinoma Int J Gynecol Pathol 2007 26 229 234 17581403
  152. [159]Denkert C Koch I von Keyserlingk N Noske A Niesporek S Dietel M Weichert W Expression of the ELAV-like protein HuR in human colon cancer: association with tumor stage and cyclooxygenase-2 Mod Pathol 2006 19 1261 1269 16799479
  153. [160]Farooq F Balabanian S Liu X Holcik M MacKenzie A p38 Mitogen-activated protein kinase stabilizes SMN mRNA through RNA-binding protein HuR Hum Mol Genet 2009 18 4035 4045 19648294
  154. [161]Doller A Pfeilschifter J Eberhardt W Signalling pathways regulating nucleo-cytoplasmic shuttling of the mRNA-binding protein HuR Cell Signal 2008 20 2165 2173 18585896
  155. [162]Al-Souhibani N, Al-Ahmadi W, Hesketh J, Blackshear P, Khabar K (2010) The RNA-binding zinc-finger protein tristetraprolin regulates AU-rich mRNAs involved in breast cancer-related processes. Oncogene (in press) PMC3422647 20498646
  156. [163]Suswam E Li Y Zhang X Gillespie GY Li X Shacka JJ Lu L Zheng L King PH Tristetraprolin down-regulates interleukin-8 and vascular endothelial growth factor in malignant glioma cells Cancer Res 2008 68 674 682 18245466
  157. [164]Kim TW Yim S Choi BJ Jang Y Lee JJ Sohn BH Yoo H-S Yeom YI Park KC Tristetraprolin regulates the stability of HIF-1[alpha] mRNA during prolonged hypoxia Biochem Biophys Res Commun 2010 391 963 968 19962963
  158. [165]Gebeshuber CA Zatloukal K Martinez J miR-29a suppresses tristetraprolin, which is a regulator of epithelial polarity and metastasis EMBO Rep 2009 10 400 405 19247375 PMC2672883
  159. [166]Schaljo B Kratochvill F Gratz N Sadzak I Sauer I Hammer M Vogl C Strobl B Muller M Blackshear PJ Poli V Lang R Murray PJ Kovarik P Tristetraprolin is required for full anti-inflammatory response of murine macrophages to IL-10 J Immunol 2009 183 1197 1206 19542371 PMC2755621
  160. [167]Correa I Veny M Esteller M Pique JM Yague J Panes J Salas A Defective IL-10 production in severe phenotypes of Crohn’s disease J Leukoc Biol 2009 85 896 903 19237638
  161. [168]Sturlan S Oberhuber G Beinhauer BG Tichy B Kappel S Wang J Rogy MA Interleukin-10-deficient mice and inflammatory bowel disease associated cancer development Carcinogenesis 2001 22 665 671 11285204
  162. [169]Mosser DM Zhang X Interleukin-10: new perspectives on an old cytokine Immunol Rev 2008 226 205 218 19161426 PMC2724982
  163. [170]Howell WM Rose-Zerilli MJ Cytokine gene polymorphisms, cancer susceptibility, and prognosis J Nutr 2007 137 194S 199S 17182825
  164. [171]Ristimaki A Narko K Hla T Down-regulation of cytokine-induced cyclo-oxygenase-2 transcript isoforms by dexamethasone: evidence for post-transcriptional regulation Biochem J 1996 318 325 331 8761489 PMC1217625
  165. [172]Touriol C Morillon A Gensac MC Prats H Prats AC Expression of human fibroblast growth factor 2 mRNA is post- transcriptionally controlled by a unique destabilizing element present in the 3’-untranslated region between alternative polyadenylation sites J Biol Chem 1999 274 21402 21408 10409702
  166. [173]Rimokh R Berger F Bastard C Klein B French M Archimbaud E Rouault JP Santa Lucia B Duret L Vuillaume M Rearrangement of CCND1 (BCL1/PRAD1) 3’ untranslated region in mantle-cell lymphomas and t(11q13)-associated leukemias Blood 1994 83 3689 3696 8204893
  167. [174]Yoo PS Mulkeen AL Cha CH Post-transcriptional regulation of vascular endothelial growth factor: implications for tumor angiogenesis World J Gastroenterol 2006 12 4937 4942 16937487 PMC4087394
  168. [175]Lejbkowicz F Goldberg-Cohen I Levy AP New horizons for VEGF. Is there a role for nuclear localization? Acta Histochem 2005 106 405 411 15707649
  169. [176]Claffey KP Shih SC Mullen A Dziennis S Cusick JL Abrams KR Lee SW Detmar M Identification of a human VPF/VEGF 3’ untranslated region mediating hypoxia-induced mRNA stability Mol Biol Cell 1998 9 469 481 9450968 PMC25276
  170. [177]Gnarra JR Zhou S Merrill MJ Wagner JR Krumm A Papavassiliou E Oldfield EH Klausner RD Linehan WM Post-transcriptional regulation of vascular endothelial growth factor mRNA by the product of the VHL tumor suppressor gene Proc Natl Acad Sci USA 1996 93 10589 10594 8855222 PMC38197
  171. [178]Sinha S Dutta S Datta K Ghosh AK Mukhopadhyay D Von Hippel-Lindau gene product modulates TIS11B expression in renal cell carcinoma: impact on vascular endothelial growth factor expression in hypoxia J Biol Chem 2009 284 32610 32618 19801654 PMC2781675
  172. [179]Danilin S Sourbier C Thomas L Rothhut S Lindner V Helwig JJ Jacqmin D Lang H Massfelder T von Hippel-Lindau tumor suppressor gene-dependent mRNA stabilization of the survival factor parathyroid hormone-related protein in human renal cell carcinoma by the RNA-binding protein HuR Carcinogenesis 2009 30 387 396 19056930
  173. [180]Piecyk M Wax S Beck AR Kedersha N Gupta M Maritim B Chen S Gueydan C Kruys V Streuli M Anderson P TIA-1 is a translational silencer that selectively regulates the expression of TNF-alpha EMBO J 2000 19 4154 4163 10921895 PMC306595
  174. [181]Gueydan C Droogmans L Chalon P Huez G Caput D Kruys V Identification of TIAR as a protein binding to the translational regulatory AU-rich element of tumor necrosis factor alpha mRNA J Biol Chem 1999 274 2322 2326 9890998
  175. [182]Phillips K Kedersha N Shen L Blackshear PJ Anderson P Arthritis suppressor genes TIA-1 and TTP dampen the expression of tumor necrosis factor alpha, cyclooxygenase 2, and inflammatory arthritis Proc Natl Acad Sci USA 2004 101 2011 2016 14769925 PMC357043
  176. [183]Dixon DA Balch GC Kedersha N Anderson P Zimmerman GA Beauchamp RD Prescott SM Regulation of cyclooxygenase-2 expression by the translational silencer TIA-1 J Exp Med 2003 198 475 481 12885872 PMC2194089
  177. [184]Raymond V Atwater JA Verma IM Removal of an mRNA destabilizing element correlates with the increased oncogenicity of proto-oncogene fos Oncogene Res 1989 5 1 12 2506502
  178. [185]Capaccioli S Quattrone A Schiavone N Calastretti A Copreni E Bevilacqua A Canti G Gong L Morelli S Nicolin A A bcl-2/IgH antisense transcript deregulates bcl-2 gene expression in human follicular lymphoma t(14;18) cell lines Oncogene 1996 13 105 115 8700536
  179. [186]Schiavone N Rosini P Quattrone A Donnini M Lapucci A Citti L Bevilacqua A Nicolin A Capaccioli S A conserved AU-rich element in the 3’ untranslated region of bcl-2 mRNA is endowed with a destabilizing function that is involved in bcl-2 down- regulation during apoptosis FASEB J 2000 14 174 184 10627292
  180. [187]Ubeda M Schmitt-Ney M Ferrer J Habener JF CHOP/GADD153 and methionyl-tRNA synthetase (MetRS) genes overlap in a conserved region that controls mRNA stability Biochem Biophys Res Commun 1999 262 31 38 10448063
  181. [188]Chesney J Mitchell R Benigni F Bacher M Spiegel L Al-Abed Y Han JH Metz C Bucala R An inducible gene product for 6-phosphofructo-2-kinase with an AU-rich instability element: role in tumor cell glycolysis and the Warburg effect Proc Natl Acad Sci USA 1999 96 3047 3052 10077634 PMC15892
  182. [189]Hamilton BJ Nichols RC Tsukamoto H Boado RJ Pardridge WM Rigby WF hnRnp A2 and hnRnp L bind the 3’UTR of glucose transporter 1 mRna and exist as a complex in vivo Biochem Biophys Res Commun 1999 261 646 651 10441480
  183. [190]Hoyle PE Steelman LS McCubrey JA Autocrine transformation of human hematopoietic cells after transfection with an activated granulocyte/macrophage colony stimulating factor gene Cytokines Cell Mol Ther 1997 3 159 168 9426974

Authors
Khabar, K. S. A.
Affiliations
King Faisal Specialist Hospital & Research Centre (SA)
Corresponding author
Khabar, Khalid S. A.
ORCID
Khabar, Khalid S. A.
Venue
Cellular and Molecular Life Sciences
Publisher
Springer Science and Business Media LLC
Published
2010-05-22
Volume
67
Issue
17
Pages
2937-2955
ISSN
  • 1420-682X (ISSN-L)
  • 1420-9071
DOI
10.1007/s00018-010-0383-x
PMC
PMC2921490
OpenAlex
W2032598909
Cited by
157
References
192
Citations by year
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FWCI
1.68
Type
journal article
Language
en
Open access
Licence
cc-by-nc
Locations
  • Cellular and Molecular Life Sciences (publishedVersion, cc-by-nc)
  • PubMed Central (publishedVersion, cc-by-nc)
  • PubMed (publishedVersion)
Topics
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › RNA Research and Splicing
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › RNA regulation and disease
  • Health Sciences › Medicine › Oncology › Cytokine Signaling Pathways and Interactions
Keywords
AU-rich elements, post-transcriptional regulation, chronic inflammation, cancer, mRNA stability, 3' untranslated region, RNA-binding proteins, cytokines, growth factors, signaling pathways, inflammation-cancer link
MeSH terms
Base Composition, Gene Expression Regulation, Humans, Inflammation, Models, Biological, Neoplasms, RNA, Messenger, Tumor Necrosis Factor-alpha, Signal Transduction, Alternative Splicing, Phosphatidylinositol 3-Kinases, 3' Untranslated Regions, Mitogen-Activated Protein Kinases, Vascular Endothelial Growth Factor A, Cyclooxygenase 2

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