Brain homeostasis: VEGF receptor 1 and 2—two unequal brothers in mind
Open accessAbstract
Vascular endothelial growth factors (VEGFs), initially thought to act specifically on the vascular system, exert trophic effects on neural cells during development and adulthood. Therefore, the VEGF system serves as a promising therapeutic target for brain pathologies, but its simultaneous action on vascular cells paves the way for harmful side effects. To circumvent these deleterious effects, many studies have aimed to clarify whether VEGFs directly affect neural cells or if the effects are mediated secondarily via other cell types, like vascular cells. A great number of reports have shown the expression and function of VEGF receptors (VEGFRs), mainly VEGFR-1 and -2, in neural cells, where VEGFR-2 has been described as the major mediator of VEGF-A signals. This review aims to summarize and compare the divergent roles of VEGFR-1 and -2 during CNS development and homeostasis.
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Apart from its role in the regulation of angiogenesis, Flt-1 (together with other members of the VEGF family) has been implicated in glial cell development and adult neurogenesis.
“Apart from its role in the regulation of angiogenesis, Flt-1 (together with other members of VEGF family) has been implicated in glial cell development and adult neurogenesis.34”
From CSF biomarkers of neuroinflammation and cerebrovascular dysfunction in early Alzheimer disease (2018) · cites this paper as [34]
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References 198 · Cited by 62
- Authors
- Wittko-Schneider, I. M., Schneider, F. T., & Plate, K. H.
- Affiliations
- Goethe University Frankfurt (DE)
- Corresponding author
- Plate, Karl H.
- ORCID
- Schneider, Fabian T.
- Venue
- Cellular and Molecular Life Sciences
- Published
- 2013-03-12
- Volume
- 70
- Issue
- 10
- Pages
- 1705-1725
- ISSN
- 1420-682X (ISSN-L)
- 1420-9071
- PMC
- PMC3632714
- OpenAlex
- W2077726070
- Cited by
- 62
- References
- 198
- Citations by year
- 2026: 4 · 2025: 6 · 2024: 8 · 2023: 4 · 2022: 7 · 2021: 6 · 2020: 3 · 2019: 4 · 2018: 2 · 2017: 2 · 2016: 5 · 2015: 5 · 2014: 3 · 2013: 3
- FWCI
- 0.50
- Type
- journal article
- Language
- en
- Open access
- hybrid
- doi.org
- Locations
- Cellular and Molecular Life Sciences (publishedVersion, cc-by)
- Europe PMC (PubMed Central) (publishedVersion, cc-by)
- PubMed Central (publishedVersion, cc-by)
- PubMed (publishedVersion)
- Publication Server of Goethe University Frankfurt am Main (Goethe University Frankfurt) (submittedVersion, cc-by)
- Funders
- Deutsche Forschungsgemeinschaft (SPP1109)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Angiogenesis and VEGF in Cancer
- Life Sciences › Neuroscience › Neurology › Barrier Structure and Function Studies
- Life Sciences › Neuroscience › Developmental Neuroscience › Neurogenesis and neuroplasticity mechanisms
- Keywords
- VEGF receptor 1, VEGF receptor 2, vascular endothelial growth factor, VEGF-A signaling, brain homeostasis, central nervous system development, vascular cells
- MeSH terms
- Animals, Brain, Cell Movement, Central Nervous System, Humans, Signal Transduction, Vascular Endothelial Growth Factor Receptor-1, Vascular Endothelial Growth Factor Receptor-2, Vascular Endothelial Growth Factors, Neurogenesis
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